Proposed Diagnostic Algorithm for Patients with Suspected Mast Cell Activation Syndrome

Valent, Peter, Akin, Cem, Bonadonna, Patrizia, Hartmann, Karin, Brockow, Knut, Niedoszytko, Marek, Nedoszytko, Boguslaw, Siebenhaar, Frank, Sperr, Wolfgang R., Oude Elberink, Joanna N.G., Butterfield, Joseph H., Alvarez-Twose, Ivan, Sotlar, Karl, Reiter, Andreas, Kluin-Nelemans, Hanneke C., Hermine, Olivier, Gotlib, Jason, Broesby-Olsen, Sigurd, Orfao, Alberto, Horny, Hans-Peter, Triggiani, Massimo, Arock, Michel, Schwartz, Lawrence B., Metcalfe, Dean D.·2019·The Journal of Allergy and Clinical Immunology: In Practice
DOI 10.1016/j.jaip.2019.01.006

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  63. [Chinese guidelines for diagnosis and treatment of systemic mastocytosis in adult patients (2022)].
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  86. Role of government action in improving buildings energy efficiency
    Eric Hirst, W. Fulkerson, R.S. Carlsmith · 1981 · OSTI OAI (U.S. Department of Energy Office of Scientific and Technical Information)
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