Cited by 201Dementia and Cognitive Impairment ResearchMemory Processes and InfluencesAlzheimer's disease research and treatments

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Temporal lobe functional activity and connectivity in young adult APOE ɛ4 carriers

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Dennis, Nancy A., Browndyke, Jeffrey N., Stokes, Jared, Need, Anna, Burke, James R., Welsh‐Bohmer, Kathleen A., Cabeza, Roberto·2010·Alzheimer's & Dementia

DOI 10.1016/j.jalz.2009.07.003PMC PMC2891943

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Abstract

Background: We sought to determine if the APOE ε4 allele influences both the functional activation and connectivity of the medial temporal lobes (MTLs) during successful memory encoding in young adults. Methods: Twenty‐four healthy young adults, i.e., 12 carriers and 12 noncarriers of the APOE ε4 allele, were scanned in a subsequent‐memory paradigm, using event‐related functional magnetic resonance imaging. The neuroanatomic correlates of successful encoding were measured as greater neural activity for subsequently remembered versus forgotten task items, or in short, encoding success activity (ESA). Group differences in ESA within the MTLs, as well as whole‐brain functional connectivity with the MTLs, were assessed. Results: In the absence of demographic or performance differences, APOE ε4 allele carriers exhibited greater bilateral MTL activity relative to noncarriers while accomplishing the same encoding task. Moreover, whereas ε4 carriers demonstrated a greater functional connectivity of ESA‐related MTL activity with the posterior cingulate and other peri‐limbic regions, reductions in overall connectivity were found across the anterior and posterior cortices. Conclusions: These results suggest that the APOE ɛ4 allele may influence not only functional activations within the MTL, but functional connectivity of the MTLs to other regions implicated in memory encoding. Enhanced functional connectivity of the MTLs with the posterior cingulate in young adult ε4 carriers suggests that APOE may be expressed early in brain regions known to be involved in Alzheimer's disease, long before late‐onset dementia is a practical risk or consideration. These functional connectivity differences may also reflect pleiotropic effects of APOE during early development.

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Authors: Dennis, N. A., Browndyke, J. N., Stokes, J., Need, A., Burke, J. R., Welsh‐Bohmer, K. A., & Cabeza, R.
Affiliations: Pennsylvania State University (US)
Duke University (US)
Joseph and Kathleen Bryan Alzheimer's Disease Research Center Duke University Durham NC USA
Corresponding author: Browndyke, Jeffrey N.
ORCID: Dennis, Nancy A.
Browndyke, Jeffrey N.
Need, Anna
Burke, James R.
Cabeza, Roberto
Venue: Alzheimer's & Dementia
Publisher: Wiley
Published: 2009-09-10
Volume: 6
Issue: 4
Pages: 303-311
ISSN: 1552-5260 (ISSN-L)
1552-5279
DOI: 10.1016/j.jalz.2009.07.003
PMC: PMC2891943
OpenAlex: W2132091452
Cited by: 201
References: 57
Citations by year: 2026: 4 · 2025: 13 · 2024: 7 · 2023: 9 · 2022: 8 · 2021: 12 · 2020: 11 · 2019: 12 · 2018: 8 · 2017: 13 · 2016: 12 · 2015: 11 · 2014: 27 · 2013: 14 · 2012: 17
FWCI: 8.22
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations: Alzheimer s & Dementia (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
Funders: National Institutes of Health (P30‐AG028377, R01‐AG23770, L30‐AG029001)
National Institute on Aging
Topics: Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
Life Sciences › Neuroscience › Cognitive Neuroscience › Memory Processes and Influences
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
Keywords: APOE ε4, medial temporal lobe
MeSH terms: Female, Genotype, Heterozygote, Hippocampus, Humans, Image Processing, Computer-Assisted, Functional Laterality, Magnetic Resonance Imaging, Male, Memory, Neural Pathways, Neuropsychological Tests, Photic Stimulation, Psychomotor Performance, Temporal Lobe, Reverse Transcriptase Polymerase Chain Reaction, Apolipoprotein E4, Young Adult

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Temporal lobe functional activity and connectivity in young adult APOE ɛ4 carriers

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