A Voxel-Based Morphometric Study of Ageing in 465 Normal Adult Human Brains
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Voxel-based-morphometry (VBM) is a whole-brain, unbiased technique for characterizing regional cerebral volume and tissue concentration differences in structural magnetic resonance images. We describe an optimized method of VBM to examine the effects of age on grey and white matter and CSF in 465 normal adults. Global grey matter volume decreased linearly with age, with a significantly steeper decline in males. Local areas of accelerated loss were observed bilaterally in the insula, superior parietal gyri, central sulci, and cingulate sulci. Areas exhibiting little or no age effect (relative preservation) were noted in the amygdala, hippocampi, and entorhinal cortex. Global white matter did not decline with age, but local areas of relative accelerated loss and preservation were seen. There was no interaction of age with sex for regionally specific effects. These results corroborate previous reports and indicate that VBM is a useful technique for studying structural brain correlates of ageing through life in humans.
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Fractional anisotropy of the SLF varies between individuals, but less importantly than volume.
“Fractional anisotropy of SLF also varies between individuals, but less importantly, than volume (67, 68).”
From Superior Longitudinal Fasciculus: A Review of the Anatomical Descriptions With Functional Correlates (2022) · cites this paper as [67]
Anatomical variability between individuals can be observed at different levels such as cortical morphology, cytoarchitecture, task-evoked activation, or dMRI connectivity pattern.
“This variability can be observed at different levels such as in cortical morphology, cytoarchitecture, task-evoked activation, or in dMRI connectivity pattern (65–68).”
From Superior Longitudinal Fasciculus: A Review of the Anatomical Descriptions With Functional Correlates (2022) · cites this paper as [67]
From one individual to another, the volume of the SLF appears different.
“from one individual to another, the volume of the SLF appears different.”
From Superior Longitudinal Fasciculus: A Review of the Anatomical Descriptions With Functional Correlates (2022) · cites this paper as [67]
VBM is an automated technique that allows for examination of brain anatomy differences between groups at a voxel-wise level without requiring predefined regions of interest.
“VBM is an automated technique that allows for the examination of brain anatomy differences between groups at a voxel-wise level without requiring predefined regions of interest (ROIs) (Good et al., 2001).”
From Multimodal MRI combined with RNA sequencing reveals pathological signatures in the 9-month-old 3×Tg-AD mouse brain (2026) · cites this paper as Good et al., 2001
Studies using ROI or VBM have yielded contradictory results regarding whether the hippocampus is preserved or deteriorates with aging.
“In spite of the objectivity of this method, studies led to somewhat contradictory results regarding the hippocampus: some authors have found this structure to be preserved with aging [29,31], whereas others have reported structural deterioration [38,81,84,87].”
From Voxel-based mapping of brain gray matter volume and glucose metabolism profiles in normal aging (2009) · cites this paper as [29]
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- Authors
- Good, C. D., Johnsrude, I. S., Ashburner, J., Henson, R. N. A., Friston, K. J., & Frackowiak, R. S. J.
- Affiliations
- UCL Queen Square Institute of Neurology (GB)
- MRC Cognition and Brain Sciences Unit (GB)
- National Hospital for Neurology and Neurosurgery (GB)
- ORCID
- Venue
- NeuroImage
- Publisher
- Elsevier BV
- Published
- 2001-07
- Volume
- 14
- Issue
- 1
- Pages
- 21-36
- ISSN
- 1053-8119 (ISSN-L)
- OpenAlex
- W2118421222
- Cited by
- 4,561
- References
- 67
- Citations by year
- 2026: 63 · 2025: 84 · 2024: 92 · 2023: 97 · 2022: 144 · 2021: 188 · 2020: 188 · 2019: 158 · 2018: 180 · 2017: 195 · 2016: 209 · 2015: 244 · 2014: 213 · 2013: 282 · 2012: 273
- FWCI
- 63.17
- Type
- journal article
- Language
- en
- Open access
- green
- figshare.com
- Licence
- Locations
- NeuroImage (publishedVersion)
- PubMed (publishedVersion)
- UCL Discovery (University College London) (submittedVersion)
- Figshare (submittedVersion, cc-by)
- Funders
- Wellcome Trust
- Topics
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Advanced Neuroimaging Techniques and Applications
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Life Sciences › Neuroscience › Cognitive Neuroscience › Functional Brain Connectivity Studies
- Keywords
- brain aging, gray matter volume, white matter, cerebrospinal fluid, sex differences, insula, superior parietal gyrus, cingulate sulcus, amygdala, hippocampus, entorhinal cortex, structural MRI
- MeSH terms
- Adolescent, Adult, Aged, Aging, Atrophy, Brain, Brain Mapping, Cephalometry, Dominance, Cerebral, Female, Humans, Image Enhancement, Image Processing, Computer-Assisted, Magnetic Resonance Imaging, Male, Middle Aged, Reference Values, Sex Factors
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