The ε4 genotype of apolipoprotein E and white matter integrity in Alzheimer's disease
Abstract
Background: In this multicenter study, we investigated a possible association between the APOE ε4 allele and white matter (WM) integrity in Alzheimer's disease (AD) using diffusion tensor imaging (DTI). Methods: We analyzed fractional anisotropy (FA) and mean diffusivity (MD) as indices of WM integrity in 70 AD patients (35 APOE ε4 carriers, 35 noncarriers) and 56 healthy control (HC) subjects (28 APOE ε4 carriers, 28 noncarriers). APOE ε4 carriers and noncarriers were matched for age and gender within each diagnostic group. Results: We found significant effects of diagnosis (Pcorrected < .05 [FWE]; i.e., smaller FA values and larger MD values in AD patients compared with HCs) and significant effects (P < .001) of APOE ε4 carrier status on MD in HCs but not in AD subjects. Conclusions: The results indicate that APOE ε4 has a moderate effect on WM integrity in HCs, but no effect on WM integrity in manifest AD.
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Prior diffusion MRI studies have identified microstructural white matter abnormalities in cognitively normal older APOE4 carriers, including increased mean diffusivity and reduced fractional anisotropy or restricted diffusion.
“Diffusion MRI studies have identified microstructural white matter (WM) abnormalities in cognitively normal older APOE4 carriers, including increased mean diffusivity and reduced fractional anisotropy or restricted diffusion [3–5]”
From Effects of APOE2 and APOE4 on brain microstructure in older adults: modification by age, sex, and cognitive status (2024) · cites this paper as [5]
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“Diffusion MRI studies have identified microstructural white matter (WM) abnormalities in cognitively normal older APOE4 carriers, including increased mean diffusivity and reduced fractional anisotropy or restricted diffusion [3–5], whereas others observed null [6, 7] or inconsistent [8] effects.”
Background
- Authors
- Kljajevic, V., Meyer, P., Holzmann, C., Dyrba, M., Kasper, E., Bokde, A. L. W., Fellgiebel, A., Meindl, T., Hampel, H., Teipel, S., & EDSD study group
- Affiliations
- DZNE German Center for Neurodegenerative Diseases Rostock Germany
- Universitätsmedizin Rostock (DE)
- German Center for Neurodegenerative Diseases (DE)
- Trinity College Dublin (IE)
- University Medical Center of the Johannes Gutenberg University Mainz (DE)
- Ludwig-Maximilians-Universität München (DE)
- Goethe University Frankfurt (DE)
- ORCID
- Venue
- Alzheimer's & Dementia
- Publisher
- Wiley
- Published
- 2013-05-23
- Volume
- 10
- Issue
- 3
- Pages
- 401-404
- ISSN
- 1552-5260 (ISSN-L)
- 1552-5279
- OpenAlex
- W1981565388
- Cited by
- 30
- References
- 23
- Citations by year
- 2026: 2 · 2024: 2 · 2023: 3 · 2022: 1 · 2020: 2 · 2019: 2 · 2018: 3 · 2017: 2 · 2016: 4 · 2015: 3 · 2014: 4 · 2013: 2
- FWCI
- 3.08
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Alzheimer s & Dementia (publishedVersion)
- PubMed (publishedVersion)
- Archivio Istituzionale della Ricerca - Università Vita-Salute San Raffaele (submittedVersion)
- DZNE Pub (submittedVersion)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Advanced Neuroimaging Techniques and Applications
- Keywords
- APOE ε4, apolipoprotein E
- MeSH terms
- Aged, Aged, 80 and over, Alzheimer Disease, Brain, Female, Genotype, Heterozygote, Humans, Male, Middle Aged, Anisotropy, Diffusion Magnetic Resonance Imaging, Apolipoprotein E4, Diffusion Tensor Imaging, White Matter
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