Cited by 233Dementia and Cognitive Impairment ResearchNeurological Disease Mechanisms and TreatmentsAlzheimer's disease research and treatments

The DOI matches its Crossref record; 53 of the 53 references it cites were found in a registry or an index.

Diabetes is associated with cerebrovascular but not Alzheimer's disease neuropathology

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Abstract

Introduction: The relationship of diabetes to specific neuropathologic causes of dementia is incompletely understood. Methods: We used logistic regression to evaluate the association between diabetes and infarcts, Braak neurofibrillary tangle stage, and neuritic plaque score in 2365 autopsied persons. In a subset of >1300 persons with available cognitive data, we examined the association between diabetes and cognition using Poisson regression. Results: Diabetes increased odds of brain infarcts (odds ratio [OR] = 1.57, P < .0001), specifically lacunes (OR = 1.71, P < .0001), but not Alzheimer's disease neuropathology. Diabetes plus infarcts was associated with lower cognitive scores at end of life than infarcts or diabetes alone, and diabetes plus high level of Alzheimer's neuropathologic changes was associated with lower mini‐mental state examination scores than the pathology alone. Discussion: This study supports the conclusions that diabetes increases the risk of cerebrovascular but not Alzheimer's disease pathology, and at least some of diabetes' relationship to cognitive impairment may be modified by neuropathology.

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Metadata

Authors
Abner, E. L., Nelson, P. T., Kryscio, R. J., Schmitt, F. A., Fardo, D. W., Woltjer, R. L., Cairns, N. J., Yu, L., Dodge, H. H., Xiong, C., Masaki, K., Tyas, S. L., Bennett, D. A., Schneider, J. A., & Arvanitakis, Z.
Affiliations
  • University of Kentucky (US)
  • Oregon Health & Science University (US)
  • Washington University in St. Louis (US)
  • Rush University Medical Center (US)
  • University of Hawaiʻi at Mānoa (US)
  • University of Waterloo (CA)
Corresponding author
Abner, Erin L.
Venue
Alzheimer's & Dementia
Publisher
Wiley
Published
2016-01-23
Volume
12
Issue
8
Pages
882-889
ISSN
  • 1552-5260 (ISSN-L)
  • 1552-5279
OpenAlex
W2287966587
Cited by
233
References
53
Citations by year
2026: 9 · 2025: 20 · 2024: 20 · 2023: 18 · 2022: 32 · 2021: 20 · 2020: 25 · 2019: 29 · 2018: 19 · 2017: 29 · 2016: 12
FWCI
26.36
Type
journal article
Language
en
Open access
Locations
  • Alzheimer s & Dementia (publishedVersion)
  • PubMed (publishedVersion)
  • Europe PMC (PubMed Central) (acceptedVersion)
  • PubMed Central (acceptedVersion)
  • UKnowledge (University of Kentucky) (submittedVersion, cc-by-nc-nd)
Funders
  • National Institute on Aging (R01‐AG038651, P30‐AG10161, R01‐AG15819, R01‐AG17917, P30‐AG028383, P50‐AG005681, P30‐AG008017, N01‐AG‐4‐2149, U01‐AG019349, U01‐AG017155)
  • National Heart, Lung, and Blood Institute (N01‐HC‐05102)
  • U.S. Department of Veterans Affairs
  • National Institute of Neurological Disorders and Stroke (R01‐NS084965)
Topics
  • Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
  • Life Sciences › Neuroscience › Neurology › Neurological Disease Mechanisms and Treatments
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
Keywords
diabetes mellitus, cerebrovascular disease
MeSH terms
Aged, 80 and over, Alzheimer Disease, Animals, Autopsy, Brain, Cognition Disorders, Diabetes Mellitus, Female, Humans, Male, Mental Status Schedule, Neuropsychological Tests, Cohort Studies, Logistic Models, Neurofibrillary Tangles, Brain Infarction, Diabetes Complications

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