Cited by 233Dementia and Cognitive Impairment ResearchNeurological Disease Mechanisms and TreatmentsAlzheimer's disease research and treatments

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Diabetes is associated with cerebrovascular but not Alzheimer's disease neuropathology

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Abner, Erin L., Nelson, Peter T., Kryscio, Richard J., Schmitt, Frederick A., Fardo, David W., Woltjer, Randall L., Cairns, Nigel J., Yu, Lei, Dodge, Hiroko H., Xiong, Chengjie, Masaki, Kamal, Tyas, Suzanne L., Bennett, David A., Schneider, Julie A., Arvanitakis, Zoe·2016·Alzheimer's & Dementia

DOI 10.1016/j.jalz.2015.12.006PMC PMC4958598

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Abstract

Introduction: The relationship of diabetes to specific neuropathologic causes of dementia is incompletely understood. Methods: We used logistic regression to evaluate the association between diabetes and infarcts, Braak neurofibrillary tangle stage, and neuritic plaque score in 2365 autopsied persons. In a subset of >1300 persons with available cognitive data, we examined the association between diabetes and cognition using Poisson regression. Results: Diabetes increased odds of brain infarcts (odds ratio [OR] = 1.57, P < .0001), specifically lacunes (OR = 1.71, P < .0001), but not Alzheimer's disease neuropathology. Diabetes plus infarcts was associated with lower cognitive scores at end of life than infarcts or diabetes alone, and diabetes plus high level of Alzheimer's neuropathologic changes was associated with lower mini‐mental state examination scores than the pathology alone. Discussion: This study supports the conclusions that diabetes increases the risk of cerebrovascular but not Alzheimer's disease pathology, and at least some of diabetes' relationship to cognitive impairment may be modified by neuropathology.

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Authors: Abner, E. L., Nelson, P. T., Kryscio, R. J., Schmitt, F. A., Fardo, D. W., Woltjer, R. L., Cairns, N. J., Yu, L., Dodge, H. H., Xiong, C., Masaki, K., Tyas, S. L., Bennett, D. A., Schneider, J. A., & Arvanitakis, Z.
Affiliations: University of Kentucky (US)
Oregon Health & Science University (US)
Washington University in St. Louis (US)
Rush University Medical Center (US)
University of Hawaiʻi at Mānoa (US)
University of Waterloo (CA)
Corresponding author: Abner, Erin L.
ORCID: Abner, Erin L.
Nelson, Peter T.
Kryscio, Richard J.
Schmitt, Frederick A.
Fardo, David W.
Woltjer, Randall L.
Yu, Lei
Dodge, Hiroko H.
Xiong, Chengjie
Masaki, Kamal
Tyas, Suzanne L.
Bennett, David A.
Schneider, Julie A.
Arvanitakis, Zoe
Venue: Alzheimer's & Dementia
Publisher: Wiley
Published: 2016-01-23
Volume: 12
Issue: 8
Pages: 882-889
ISSN: 1552-5260 (ISSN-L)
1552-5279
DOI: 10.1016/j.jalz.2015.12.006
PMC: PMC4958598
OpenAlex: W2287966587
Cited by: 233
References: 53
Citations by year: 2026: 9 · 2025: 20 · 2024: 20 · 2023: 18 · 2022: 32 · 2021: 20 · 2020: 25 · 2019: 29 · 2018: 19 · 2017: 29 · 2016: 12
FWCI: 26.36
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations: Alzheimer s & Dementia (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
UKnowledge (University of Kentucky) (submittedVersion, cc-by-nc-nd)
Funders: National Institute on Aging (R01‐AG038651, P30‐AG10161, R01‐AG15819, R01‐AG17917, P30‐AG028383, P50‐AG005681, P30‐AG008017, N01‐AG‐4‐2149, U01‐AG019349, U01‐AG017155)
National Heart, Lung, and Blood Institute (N01‐HC‐05102)
U.S. Department of Veterans Affairs
National Institute of Neurological Disorders and Stroke (R01‐NS084965)
Topics: Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
Life Sciences › Neuroscience › Neurology › Neurological Disease Mechanisms and Treatments
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
Keywords: diabetes mellitus, cerebrovascular disease
MeSH terms: Aged, 80 and over, Alzheimer Disease, Animals, Autopsy, Brain, Cognition Disorders, Diabetes Mellitus, Female, Humans, Male, Mental Status Schedule, Neuropsychological Tests, Cohort Studies, Logistic Models, Neurofibrillary Tangles, Brain Infarction, Diabetes Complications

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Diabetes is associated with cerebrovascular but not Alzheimer's disease neuropathology

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