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Cited by 192

The DOI matches its Crossref record; 15 of the 15 references it cites were found in a registry or an index.

Cerebral small vessel disease and the risk of dementia: A systematic review and meta‐analysis of population‐based evidence

Bos, Daniel, Wolters, Frank J., Darweesh, Sirwan K.L., Vernooij, Meike W., de Wolf, Frank, Ikram, M. Arfan, Hofman, Albert·2018·Alzheimer's & Dementia
DOI 10.1016/j.jalz.2018.04.007
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Abstract

Introduction: Cerebral small vessel disease is increasingly linked to dementia. Methods: We systematically searched Medline, Embase, and Cochrane databases for prospective population‐based studies addressing associations of white matter hyperintensities, covert brain infarcts (i.e., clinically silent infarcts), and cerebral microbleeds with risk of all‐dementia or Alzheimer's disease and performed meta‐analyses. Results: We identified 11 studies on white matter hyperintensities, covert brain infarcts, or cerebral microbleeds with risk of all‐dementia or Alzheimer's disease. Pooled analyses showed an association of white matter hyperintensity volume and a borderline association of covert brain infarcts with risk of all‐dementia (hazard ratio: 1.39 [95% confidence interval: 1.00; 1.94], N = 3913, and 1.47 [95% confidence interval: 0.97; 2.22], N = 8296). Microbleeds were not statistically significantly associated with an increased risk of all‐dementia (hazard ratio: 1.25 [95% confidence interval: 0.66; 2.38], N = 8739). Discussion: White matter hyperintensities are associated with an increased risk of all‐dementia and Alzheimer's disease in the general population. However, studies are warranted to further determine the role of markers of cerebral small vessel disease in dementia.

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Crossref · 10.1016/j.jalz.2018.04.007

Cites

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Research works printed but not linked: 47

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Metadata

Authors
Bos, D., Wolters, F. J., Darweesh, S. K. L., Vernooij, M. W., de Wolf, F., Ikram, M. A., & Hofman, A.
Venue
Alzheimer's & Dementia
Publisher
Wiley
Published
2018-05-21
Volume
14
Issue
11
Pages
1482-1492
ISSN
  • 1552-5260
  • 1552-5279
DOI
10.1016/j.jalz.2018.04.007
Cited by
192
References
15
Language
en
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor)

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CoChat. (2026). Citation check: Cerebral small vessel disease and the risk of dementia: A systematic review and meta‐analysis of population‐based evidence. https://app.cochat.ai/papers/10.1016/j.jalz.2018.04.007
The paper
Bos, D., Wolters, F. J., Darweesh, S. K. L., Vernooij, M. W., de Wolf, F., Ikram, M. A., & Hofman, A. (2018). Cerebral small vessel disease and the risk of dementia: A systematic review and meta‐analysis of population‐based evidence. Alzheimer's & Dementia. https://doi.org/10.1016/j.jalz.2018.04.007

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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.