The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Nipple-Sparing Mastectomy for Breast Cancer and Risk Reduction: Oncologic or Technical Problem?
Abstract
BACKGROUND: We evaluated the risks and benefits of nipple-sparing mastectomy in a multiinstitutional experience in the settings of risk-reducing surgery and breast cancer treatment. STUDY DESIGN: We analyzed data on 123 patients who had undergone nipple-sparing mastectomy with breast reconstruction for prophylaxis (n=55), treatment of breast cancer (n=41), or both (n=27) at four large centers. RESULTS: Median patient age was 45 years (range 22 to 70 years). There were 192 procedures (69 bilateral, 54 unilateral). Forty-four patients had invasive cancer; 20 had ductal carcinoma in situ (DCIS); 4 had phyllodes tumor. In all of these patients, the nipple tissue was cancer free on pathologic review. Median followup was 24.6 months (range 2.0 to 570.4 months). Local recurrence developed in two patients: one had DCIS in the upper-outer quadrant, with 71.8 months of followup; the other's cancer was invasive, in the upper-outer quadrant, with 6 months of followup. Distant metastasis developed in a third patient, who died 50 months after the procedure. Breast cancer developed in two patients after prophylactic mastectomy: one in the upper-outer quadrant at 61.8 months; one in the axillary tail at 24.4 months. No patients had recurrences in the nipple-areolar complex. Necrosis of the nipple was reported in 22 of 192 patients (11%) and it was judged minimal (less than one-third total skin of nipple) in 13 of 22 patients (59%). Overall cosmesis was judged by the patient and surgeon as good to excellent in the majority of patients. Level of satisfaction with cosmetic results was similar between prophylactic and treatment patients. CONCLUSIONS: The risk of local relapse was very low in our series of nipple-sparing mastectomies performed for DCIS or invasive cancer. Nipple-sparing mastectomy in the risk-reducing and breast cancer-treatment settings may be feasible in selected patients and should be the subject of additional prospective clinical trials.
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Citations
Cites
Breast Cancer after Prophylactic Bilateral Mastectomy in Women with a BRCA1 or BRCA2 Mutation
Meijers-Heijboer, H., van Geel, B., van Putten, W. L. J., Henzen-Logmans, S. C., Seynaeve, C., Menke-Pluymers, M. B. E., Bartels, C. C. M., Verhoog, L. C., van den Ouweland, A. M. W., Niermeijer, M. F., et al. (2001) · New England Journal of Medicine · doi:10.1056/nejm200107193450301 · Cited by 973
Efficacy of Bilateral Prophylactic Mastectomy in BRCA1 and BRCA2 Gene Mutation Carriers
Hartmann, L. C., Sellers, T. A., Schaid, D. J., Frank, T. S., Soderberg, C. L., Sitta, D. L., Frost, M. H., Grant, C. S., Donohue, J. H., Woods, J. E., et al. (2001) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/93.21.1633 · Cited by 743
Cited by
Gerber, B., Krause, A., Dieterich, M., Kundt, G., & Reimer, T. (2009) · Annals of Surgery · doi:10.1097/sla.0b013e31819a044f · Cited by 396
Metadata
- Authors
- Sacchini, V., Pinotti, J. A., Barros, A. C. S. D., Luini, A., Pluchinotta, A., Pinotti, M., Boratto, M. G., Ricci, M. D., Ruiz, C. A., Nisida, A. C., Veronesi, P., Petit, J., Arnone, P., Bassi, F., Disa, J. J., Garcia-Etienne, C. A., & Borgen, P. I.
- Venue
- Journal of the American College of Surgeons
- Published
- 2006-11
- Volume
- 203
- Issue
- 5
- Pages
- 704-714
- ISSN
- 1072-7515 (ISSN-L)
- OpenAlex
- W2066509456
- Cited by
- 321
- References
- 2
- FWCI
- 19.01
- Type
- journal article
- Language
- en
- Open access
- closed
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- The paper
- Sacchini, V., Pinotti, J. A., Barros, A. C. S. D., Luini, A., Pluchinotta, A., Pinotti, M., Boratto, M. G., Ricci, M. D., Ruiz, C. A., Nisida, A. C., Veronesi, P., Petit, J., Arnone, P., Bassi, F., Disa, J. J., Garcia-Etienne, C. A., & Borgen, P. I. (2006). Nipple-Sparing Mastectomy for Breast Cancer and Risk Reduction: Oncologic or Technical Problem? Journal of the American College of Surgeons. https://doi.org/10.1016/j.jamcollsurg.2006.07.015
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
