The DOI matches its Crossref record; 27 of the 27 references it cites were found in a registry or an index.
Kinetic Growth Rate after Portal Vein Embolization Predicts Posthepatectomy Outcomes: Toward Zero Liver-Related Mortality in Patients with Colorectal Liver Metastases and Small Future Liver Remnant
Open accessAbstract
BACKGROUND: Standardized future liver remnant (sFLR) volume and degree of hypertrophy after portal vein embolization (PVE) have been recognized as important predictors of surgical outcomes after major liver resection. However, the regeneration rate of the FLR after PVE varies among individuals and its clinical significance is unknown. STUDY DESIGN: Kinetic growth rate (KGR) is defined as the degree of hypertrophy at initial volume assessment divided by number of weeks elapsed after PVE. In 107 consecutive patients who underwent liver resection for colorectal liver metastases with an sFLR volume >20%, the ability of the KGR to predict overall and liver-specific postoperative morbidity and mortality was compared with sFLR volume and degree of hypertrophy. RESULTS: Using receiver operating characteristic analysis, the best cutoff values for sFLR volume, degree of hypertrophy, and KGR for predicting postoperative hepatic insufficiency were estimated as 29.6%, 7.5%, and 2.0% per week, respectively. Among these, KGR was the most accurate predictor (area under the curve 0.830 [95% CI, 0.736-0.923]; asymptotic significance, 0.002). A KGR of <2% per week vs ≥2% per week correlates with rates of hepatic insufficiency (21.6% vs 0%; p = 0.0001) and liver-related 90-day mortality (8.1% vs 0%; p = 0.04). The predictive value of KGR was not influenced by sFLR volume or the timing of initial volume assessment when evaluated within 8 weeks after PVE. CONCLUSIONS: Kinetic growth rate is a better predictor of postoperative morbidity and mortality after liver resection for small FLR than conventional measured volume parameters (ie, sFLR volume and degree of hypertrophy).
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Cited by
Guiu, B., Chevallier, P., Denys, A., Delhom, E., Pierredon-Foulongne, M.-A., Rouanet, P., Fabre, J.-M., Quenet, F., Herrero, A., Panaro, F., et al. (2016) · European Radiology · doi:10.1007/s00330-016-4291-9 · Cited by 205
First-in-class MKK4 inhibitors enhance liver regeneration and prevent liver failure
Zwirner, S., Abu Rmilah, A. A., Klotz, S., Pfaffenroth, B., Kloevekorn, P., Moschopoulou, A. A., Schuette, S., Haag, M., Selig, R., Li, K., et al. (2024) · Cell · doi:10.1016/j.cell.2024.02.023 · Cited by 65
Haddad, A., Khavandi, M. M., Lendoire, M., Acidi, B., Chiang, Y.-J., Gupta, S., Tam, A., Odisio, B. C., Mahvash, A., Abdelsalam, M. E., et al. (2025) · Annals of Surgical Oncology · doi:10.1245/s10434-024-16558-1 · Cited by 10
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Metadata
- Authors
- Shindoh, J., Truty, M. J., Aloia, T. A., Curley, S. A., Zimmitti, G., Huang, S. Y., Mahvash, A., Gupta, S., Wallace, M. J., & Vauthey, J.-N.
- Venue
- Journal of the American College of Surgeons
- Published
- 2013-02
- Volume
- 216
- Issue
- 2
- Pages
- 201-209
- ISSN
- 1072-7515 (ISSN-L)
- OpenAlex
- W2039272512
- Cited by
- 329
- References
- 27
- FWCI
- 7.81
- Type
- journal article
- Language
- en
- Open access
- green
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- Shindoh, J., Truty, M. J., Aloia, T. A., Curley, S. A., Zimmitti, G., Huang, S. Y., Mahvash, A., Gupta, S., Wallace, M. J., & Vauthey, J.-N. (2013). Kinetic Growth Rate after Portal Vein Embolization Predicts Posthepatectomy Outcomes: Toward Zero Liver-Related Mortality in Patients with Colorectal Liver Metastases and Small Future Liver Remnant. Journal of the American College of Surgeons. https://doi.org/10.1016/j.jamcollsurg.2012.10.018
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