Supervised Exercise (Vivifrail) Protects Institutionalized Older Adults Against Severe Functional Decline After 14 Weeks of COVID Confinement
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In older adults with sarcopenia living in nursing homes, a tailored multicomponent exercise program (VIVIFRAIL) produced significant improvements in both functional capacity and strength.
“The results demonstrated significant improvements in both functional capacity and strength, with 36% of participants changing scores to “robust” or “non-frail” and 59% achieving a high level of self-autonomy at 4 weeks.”
From Global consensus on optimal exercise recommendations for enhancing healthy longevity in older adults (ICFSR) (2025) · cites this paper as [243]
Recent evidence suggests that exercise confers a protective effect even after short and long-term cessations, which is particularly relevant for frail and institutionalized populations.
“Despite these interruptions, recent evidence suggests that exercise confers a protective effect even after short and long-term cessations, which is particularly relevant for frail and institutionalized populations.”
From Global consensus on optimal exercise recommendations for enhancing healthy longevity in older adults (ICFSR) (2025) · cites this paper as [243]
Although detraining led to a 10%-25% decline in functional capacity, the improvements remained well above baseline levels.
“Although detraining led to a 10%–25% decline in functional capacity, the improvements remained well above baseline levels.”
From Global consensus on optimal exercise recommendations for enhancing healthy longevity in older adults (ICFSR) (2025) · cites this paper as [243]
Participants in the long-term training group saw additional benefits, with a further 10%-20% enhancement in performance compared to the short-term group.
“Participants in the long-term training group saw additional benefits, with a further 10%–20% enhancement in performance compared to the short-term group.”
From Global consensus on optimal exercise recommendations for enhancing healthy longevity in older adults (ICFSR) (2025) · cites this paper as [243]
Intermittent exercise strategies-such as 4-week training blocks repeated three times per year-have the potential to sustain and enhance functional capacity in frail older adults, even in the face of inevitable periods of inactivity.
“These findings suggest the potential of intermittent exercise strategies—such as 4-week training blocks repeated three times per year—to sustain and enhance functional capacity in frail older adults, even in the face of inevitable periods of inactivity [243,251].”
From Global consensus on optimal exercise recommendations for enhancing healthy longevity in older adults (ICFSR) (2025) · cites this paper as [243]
In that study, 36% of participants changed scores to robust or non-frail and 59% achieved a high level of self-autonomy at 4 weeks.
“The results demonstrated significant improvements in both functional capacity and strength, with 36% of participants changing scores to “robust” or “non-frail” and 59% achieving a high level of self-autonomy at 4 weeks.”
From Global consensus on optimal exercise recommendations for enhancing healthy longevity in older adults (ICFSR) (2025) · cites this paper as [243]
Cognitive performance, executive function, and mobility can continue to improve or retain improvements even after training stops.
“Conversely, cognitive performance, executive function, and mobility can continue to improve or retain improvements even after training stops, as noted above in the study by Courel-Ibáñez et al. [243,251] and others [[273], [274], [275]].”
From Global consensus on optimal exercise recommendations for enhancing healthy longevity in older adults (ICFSR) (2025) · cites this paper as [243]
The VIVIFRAIL multicomponent program has shown potential as an effective intervention for maintaining and ameliorating physical frailty in vulnerable institutionalized older adults.
“The VIVIFRAIL multicomponent program has shown potential as an effective intervention for maintaining and ameliorate physical frailty in vulnerable institutionalized older adults [243,251].”
From Global consensus on optimal exercise recommendations for enhancing healthy longevity in older adults (ICFSR) (2025) · cites this paper as [243]
Although detraining led to a 10%-25% decline in functional capacity, improvements remained well above baseline levels.
“Although detraining led to a 10%–25% decline in functional capacity, the improvements remained well above baseline levels.”
From Global consensus on optimal exercise recommendations for enhancing healthy longevity in older adults (ICFSR) (2025) · cites this paper as [243]
In a study by Courel-Ibáñez et al., significant improvements in functional capacity and strength were demonstrated, with 36% of participants changing scores to robust or non-frail and 59% achieving a high level of self-autonomy at 4 weeks.
“The results demonstrated significant improvements in both functional capacity and strength, with 36% of participants changing scores to “robust” or “non-frail” and 59% achieving a high level of self-autonomy at 4 weeks.”
From Global consensus on optimal exercise recommendations for enhancing healthy longevity in older adults (ICFSR) (2025) · cites this paper as [243]
Findings suggest potential of intermittent exercise strategies-such as 4-week training blocks repeated three times per year-to sustain and enhance functional capacity in frail older adults even in the face of periods of inactivity.
“These findings suggest the potential of intermittent exercise strategies—such as 4-week training blocks repeated three times per year—to sustain and enhance functional capacity in frail older adults, even in the face of inevitable periods of inactivity [243,251].”
From Global consensus on optimal exercise recommendations for enhancing healthy longevity in older adults (ICFSR) (2025) · cites this paper as [243]
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References 10 · Cited by 49
- Authors
- Courel-Ibáñez, J., Pallarés, J. G., García-Conesa, S., Buendía-Romero, Á., Martínez-Cava, A., & Izquierdo, M.
- Affiliations
- Universidad de Murcia (ES)
- Venue
- Journal of the American Medical Directors Association
- Publisher
- Elsevier BV
- Published
- 2021-01
- Volume
- 22
- Issue
- 1
- Pages
- 217-219.e2
- ISSN
- 1525-8610 (ISSN-L)
- PMC
- PMC7837301
- OpenAlex
- W3113021743
- Cited by
- 49
- References
- 10
- Citations by year
- 2026: 2 · 2025: 7 · 2024: 4 · 2023: 10 · 2022: 14 · 2021: 11
- FWCI
- 5.26
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Journal of the American Medical Directors Association (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Federación Española de Enfermedades Raras
- Instituto de Salud Carlos III
- Ministerio de Asuntos Económicos y Transformación Digital, Gobierno de España (PI17/01814)
- Topics
- Health Sciences › Medicine › Physiology › Nutrition and Health in Aging
- Health Sciences › Medicine › Physiology › Physical Activity and Health
- Health Sciences › Medicine › Geriatrics and Gerontology › Frailty in Older Adults
- Keywords
- supervised exercise, Vivifrail, older adults, institutionalized elderly, COVID-19 lockdown, functional decline, physical inactivity, disuse atrophy, muscle atrophy, disability, exercise rehabilitation
- MeSH terms
- COVID-19, SARS-CoV-2, Aged, Exercise Therapy, Humans, Exercise, Frail Elderly
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