A low glycemic index and glycemic load diet decreases insulin-like growth factor-1 among adults with moderate and severe acne: a short-duration, 2-week randomized controlled trial
Abstract
Background A high glycemic index (GI) and glycemic load (GL) diet may stimulate acne proliferative pathways by influencing biochemical factors associated with acne. However, few randomized controlled trials have examined this relationship, and this process is not completely understood. Objective This study examined changes in biochemical factors associated with acne among adults with moderate to severe acne after following a low GI and GL diet or usual eating plan for 2 weeks. Design This study utilized a parallel randomized controlled design to compare the effect of a low GI and GL diet to usual diet on biochemical factors associated with acne (glucose, insulin, insulin-like growth factor [IGF]-1, and insulin-like growth factor binding protein [IGFBP]-3) and insulin resistance after 2 weeks. Participants Sixty-six participants were randomly allocated to the low GI and GL diet (n=34) or usual eating plan (n=32) and included in the analyses. Main outcome measures The primary outcomes were biochemical factors of acne and insulin resistance with dietary intake as a secondary outcome. Statistical analyses Independent sample t tests assessed changes in biochemical factors associated with acne, dietary intake, and body composition pre- and postintervention, comparing the two dietary interventions. Results IGF-1 concentrations decreased significantly among participants randomized to a low GI and GL diet between pre- and postintervention time points (preintervention=267.3±85.6 mg/mL,…
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Some reviewed studies (Burris et al, Ismail et al) hewed closer to ideal through use of food diaries and/or telephone interviews in their assessment of participants' diets.
“Some of the reviewed studies, such as those by Burris et al59 and Ismail et al,34 both of which concluded that increased dairy and GI consumption exacerbate acne, hewed closer to this ideal through the use of food diaries and/or telephone interviews in their assessment of participants’ diets.”
From Diet and acne: A systematic review (2022) · cites this paper as [59]
Cites
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Dietary Fiber, Glycemic Load, and Risk of Non—insulin-dependent Diabetes Mellitus in Women
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Side effects of common acne treatments
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Diet and acne: A systematic review
Meixiong, J., Ricco, C., Vasavda, C., & Ho, B. K. (2022) · JAAD International · doi:10.1016/j.jdin.2022.02.012 · Cited by 108 · see citing works
- Authors
- Burris, J., Shikany, J. M., Rietkerk, W., & Woolf, K.
- Corresponding author
- Burris, Jennifer
- Venue
- Journal of the Academy of Nutrition and Dietetics
- Publisher
- Elsevier BV
- Published
- 2018-10
- Volume
- 118
- Issue
- 10
- Pages
- 1874-1885
- ISSN
- 2212-2672 (ISSN-L)
- OpenAlex
- W2800276374
- Cited by
- 75
- References
- 4
- Citations by year
- 2026: 9 · 2025: 16 · 2024: 14 · 2023: 4 · 2022: 15 · 2021: 9 · 2020: 3 · 2019: 5
- FWCI
- 4.46
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of the Academy of Nutrition and Dietetics (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Dermatology › Acne and Rosacea Treatments and Effects
- Health Sciences › Medicine › Reproductive Medicine › Ovarian function and disorders
- Health Sciences › Medicine › Physiology › Diet and metabolism studies
- Keywords
- acne, low glycemic index diet, glycemic load, insulin-like growth factor I, insulin-like growth factor binding protein-3, insulin resistance, dietary intervention, acne pathogenesis, carbohydrate intake, body composition, acne treatment
- MeSH terms
- Glycemic Load, Acne Vulgaris, Adult, Female, Humans, Insulin Resistance, Insulin-Like Growth Factor I, Male, Time Factors, Treatment Outcome, Insulin-Like Growth Factor Binding Protein 3, Glycemic Index, Young Adult
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