Side effects of common acne treatments
Abstract
INTRODUCTION: A variety of acne treatments exist, including topical benzoyl peroxide, topical retinoids, topical antibiotics, oral antibiotics, hormonal therapy, isotretinoin, and procedural therapies, such as light and laser therapies. Although each of these treatment modalities confer various benefits for the management of acne, it is important for healthcare providers to be aware of their potential side effects, including ones that are most common and most serious, so that these medications can be prescribed in a safe manner. AREAS COVERED: A systematic literature review was performed to identify publications discussing the side effects of the different treatment modalities used for acne vulgaris. Acne treatments reviewed included benzoyl peroxide gel, topical retinoids, topical antibiotics, oral antibiotics, hormonal therapy, isotretinoin, and light/laser treatments. EXPERT OPINION: A comprehensive overview of acne treatments' side effects is imperative for healthcare professionals and scientists working with and prescribing acne treatments. Side effects to be aware of when prescribing range from local irritation with topical treatments to systemic side effects including liver function abnormalities and teratogenic side effects. The best available options are those that address acne severity while minimizing side effects for the patient. Consequently, personalized medicine must be strongly emphasized to healthcare providers developing patients' treatment plans.
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Acne medications-both topical and systemic-can cause cutaneous irritation along with other adverse events.
“Acne medications—both topical and systemic—can cause cutaneous irritation along with other adverse events.15, 46”
From International expert consensus recommendations for the use of dermocosmetics in acne. (2025) · cites this paper as [46]
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- Authors
- Tripathi, S. V., Gustafson, C. J., Huang, K. E., & Feldman, S. R.
- Affiliations
- Wake Forest University Health Sciences (US)
- Wake Forest University (US)
- Venue
- Expert Opinion on Drug Safety
- Publisher
- Informa UK Limited
- Published
- 2012-11-20
- Volume
- 12
- Issue
- 1
- Pages
- 39-51
- ISSN
- 1474-0338 (ISSN-L)
- 1744-764X
- OpenAlex
- W2135486797
- Cited by
- 70
- References
- 96
- Citations by year
- 2026: 4 · 2025: 7 · 2024: 6 · 2023: 4 · 2022: 3 · 2021: 5 · 2020: 9 · 2019: 4 · 2018: 4 · 2017: 3 · 2016: 5 · 2015: 2 · 2014: 7 · 2013: 6
- FWCI
- 0.97
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Expert Opinion on Drug Safety (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Dermatology › Acne and Rosacea Treatments and Effects
- Health Sciences › Medicine › Dermatology › Dermatology and Skin Diseases
- Health Sciences › Medicine › Dermatology › Dermatologic Treatments and Research
- Keywords
- acne, benzoyl peroxide, topical retinoids, topical antibiotics, oral antibiotics, hormone therapy, isotretinoin, liver dysfunction, teratogenicity, drug safety, personalized medicine
- MeSH terms
- Acne Vulgaris, Dermatologic Agents, Drug Administration Routes, Humans, Phototherapy, Risk Factors, Treatment Outcome, Risk Assessment, Patient Selection, Low-Level Light Therapy
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