The DOI matches its Crossref record; 158 of the 158 references it cites were found in a registry or an index.
Uric acid in the pathogenesis of metabolic, renal, and cardiovascular diseases: A review
Open accessAbstract
The association between uric acid (UA) on one side and systemic hypertension (Htn), dyslipidemia, glucose intolerance, overweight, fatty liver, renal disease and cardiovascular disease (CVD) on the other side is well recognized. However, the causal relationship between UA and these different clinical problems is still debatable. The recent years have witnessed hundreds of experimental and clinical trials that favored the opinion that UA is a probable player in the pathogenesis of these disease entities. These studies disclosed the strong association between hyperuricemia and metabolic syndrome (MS), obesity, Htn, type 2 diabetes mellitus (DM), non-alcoholic fatty liver disease, hypertriglyceridemia, acute kidney injury, chronic kidney disease (CKD), coronary heart disease (CHD), heart failure and increased mortality among cardiac and CKD patients. The association between UA and nephrolithiasis or preeclampsia is a non-debatable association. Recent experimental trials have disclosed different changes in enzyme activities induced by UA. Nitric oxide (NO) synthase, adenosine monophosphate kinase (AMPK), adenosine monophosphate dehydrogenase (AMPD), and nicotinamide adenine dinucleotide phosphate (NADPH)-oxidase are affected by UA. These changes in enzymatic activities can lead to the observed biochemical and pathological changes associated with UA. The recent experimental, clinical, interventional, and epidemiologic trials favor the concept of a causative role of UA in the pathogenesis of MS, renal, and CVDs.
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Cited by
Zhao, Y., Xu, L., Tian, D., Xia, P., Zheng, H., Wang, L., & Chen, L. (2018) · Diabetes, Obesity and Metabolism · doi:10.1111/dom.13101 · Cited by 333
Metadata
- Authors
- Sharaf El Din, U. A. A., Salem, M. M., & Abdulazim, D. O.
- Venue
- Journal of Advanced Research
- Publisher
- Elsevier BV
- Published
- 2017-09
- Volume
- 8
- Issue
- 5
- Pages
- 537-548
- ISSN
- 2090-1224 (ISSN-L)
- 2090-1232
- OpenAlex
- W2559229196
- Cited by
- 417
- References
- 158
- FWCI
- 20.56
- Type
- journal article
- Language
- en
- Open access
- gold
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- Sharaf El Din, U. A. A., Salem, M. M., & Abdulazim, D. O. (2017). Uric acid in the pathogenesis of metabolic, renal, and cardiovascular diseases: A review. Journal of Advanced Research. https://doi.org/10.1016/j.jare.2016.11.004
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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