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Cited by 25Blood Pressure and Hypertension StudiesPotassium and Related DisordersSodium Intake and Health

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Effects of low-dose thiazide diuretics on fasting plasma glucose and serum potassium-a meta-analysis

Mukete, Bertrand N., Rosendorff, Clive·2013·Journal of the American Society of Hypertension
DOI 10.1016/j.jash.2013.05.004
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Abstract

This study is a meta-analysis of the metabolic profile (fasting plasma glucose and serum potassium) of low-dose thiazide and thiazide-like diuretics. The meta-analysis involved 10 randomized controlled clinical trials with a total sample size of 17,636 and 17,947 for the potassium and glucose arms respectively. The random effect model was used to calculate the odds ratio with 95 percent confidence interval. The cumulative mean change of fasting plasma glucose was +0.20 mmol/L (+3.6 mg/dL) for the diuretic arm versus +0.12 mmol/L (+2.2 mg/dL) for the comparator arm. The cumulative mean change of serum potassium was -0.22 mmol/L (-0.22 mEq/L) for the diuretic arm versus +0.05 mmol/L (+0.05 mEq/L) for the comparator arm. The aggregate odds ratio for having higher fasting plasma glucose in subjects on low-dose thiazide versus non-thiazide antihypertensive was 1.22 (1.11 to 1.33; P < .01). The odds ratio for having a lower serum potassium in subjects on low-dose thiazide versus non-thiazide antihypertensive was 0.36 (0.27 to 0.49; P < .01). The magnitude of the observed change in fasting plasma glucose associated with low-dose thiazide diuretic use, while statistically significant, does not appear to place patients at clinically significant risk. On the other hand, the observed change in serum potassium was also statistically significant, and may be clinically significant in patients whose baseline potassium concentration is low or low-normal, and could predispose at-risk patients…

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Cited by

Metadata

Authors
Mukete, B. N., & Rosendorff, C.
Affiliations
  • Icahn School of Medicine at Mount Sinai (US)
  • James J. Peters VA Medical Center (US)
Corresponding author
Rosendorff, Clive
ORCID
Rosendorff, Clive
Venue
Journal of the American Society of Hypertension
Publisher
Elsevier BV
Published
2013-11
Volume
7
Issue
6
Pages
454-466
ISSN
  • 1878-7436 (ISSN-L)
  • 1933-1711
DOI
10.1016/j.jash.2013.05.004
OpenAlex
W2072879762
Cited by
25
References
1
Citations by year
2026: 1 · 2025: 1 · 2024: 1 · 2023: 1 · 2022: 1 · 2021: 1 · 2020: 1 · 2019: 3 · 2018: 2 · 2017: 1 · 2016: 2 · 2015: 9 · 2014: 1
FWCI
0.68
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Journal of the American Society of Hypertension (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Blood Pressure and Hypertension Studies
  • Health Sciences › Medicine › Nephrology › Potassium and Related Disorders
  • Health Sciences › Nursing › Nutrition and Dietetics › Sodium Intake and Health
Keywords
thiazide diuretics, low-dose diuretics, fasting blood glucose, serum potassium, antihypertensive drugs, metabolic effects, ventricular arrhythmias, ischemic heart disease
MeSH terms
Blood Glucose, Dose-Response Relationship, Drug, Fasting, Humans, Hypertension, Hypokalemia, Potassium, Risk Factors, Randomized Controlled Trials as Topic, Sodium Chloride Symporter Inhibitors

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