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Generation and detection of multiply-charged peptides and proteins by matrix-assisted laser desorption electrospray ionization (MALDESI) fourier transform ion cyclotron resonance mass spectrometry
Abstract
We report the coupling of a hybrid ionization source, matrix-assisted laser desorption electrospray ionization (MALDESI), to a Fourier transform-ion cyclotron resonance mass spectrometer (FT-ICR MS). The details of the source design and initial data are presented. Analysis of peptides and proteins ranging from 1 to 8.6 kDa resulted in high resolving power single-acquisition FT-ICR mass spectra with average charge-states highly correlated to those obtained by nanoESI, thus, providing strong evidence that the ESI process dictates the observed charge-state distribution. Importantly, unlike the recently introduced electrospray assisted laser desorption ionization (ELDI) source reported by Shiea and coworkers [1, 2], the data we have obtained to date rely on the use of an organic acid matrix. The results presented herein provide insight into the charging mechanism of this emerging ionization approach, while also expanding the utility of FT-ICR MS for top-down protein and complex mixture analysis.
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Citations
Cites
Electrospray Ionization for Mass Spectrometry of Large Biomolecules
Fenn, J. B., Mann, M., Meng, C. K., Wong, S. F., & Whitehouse, C. M. (1989) · Science · doi:10.1126/science.2675315 · Cited by 7,634
Cited by
Nemes, P., & Vertes, A. (2007) · Analytical Chemistry · doi:10.1021/ac071181r · Cited by 817
Low-Temperature Plasma Probe for Ambient Desorption Ionization
Harper, J. D., Charipar, N. A., Mulligan, C. C., Zhang, X., Cooks, R. G., & Ouyang, Z. (2008) · Analytical Chemistry · doi:10.1021/ac801641a · Cited by 730
Ambient desorption ionization mass spectrometry
Venter, A., Nefliu, M., & Graham Cooks, R. (2008) · TrAC Trends in Analytical Chemistry · doi:10.1016/j.trac.2008.01.010 · Cited by 552
Ambient Sampling/Ionization Mass Spectrometry: Applications and Current Trends
Harris, G. A., Galhena, A. S., & Fernández, F. M. (2011) · Analytical Chemistry · doi:10.1021/ac200918u · Cited by 527
Ambient mass spectrometry: bringing MS into the “real world”
Alberici, R. M., Simas, R. C., Sanvido, G. B., Romão, W., Lalli, P. M., Benassi, M., Cunha, I. B. S., & Eberlin, M. N. (2010) · Analytical and Bioanalytical Chemistry · doi:10.1007/s00216-010-3808-3 · Cited by 340
Metadata
- Authors
- Sampson, J. S., Hawkridge, A. M., & Muddiman, D. C.
- Venue
- Journal of the American Society for Mass Spectrometry
- Publisher
- American Chemical Society (ACS)
- Published
- 2006-12-01
- Volume
- 17
- Issue
- 12
- Pages
- 1712-1716
- ISSN
- 1044-0305 (ISSN-L)
- OpenAlex
- W1972050584
- Cited by
- 375
- References
- 1
- FWCI
- 9.32
- Type
- journal article
- Language
- en
- Open access
- closed
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- Sampson, J. S., Hawkridge, A. M., & Muddiman, D. C. (2006). Generation and detection of multiply-charged peptides and proteins by matrix-assisted laser desorption electrospray ionization (MALDESI) fourier transform ion cyclotron resonance mass spectrometry. Journal of the American Society for Mass Spectrometry. https://doi.org/10.1016/j.jasms.2006.08.003
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