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Do ionic charges in ESI MS provide useful information on macromolecular structure?
Abstract
Multiple charging is an intrinsic feature of electrospray ionization (ESI) of macromolecules. While multiple factors influence the appearance of protein ion charge state distributions in ESI mass spectra, physical dimensions of protein molecules in solution are the major determinants of the extent of multiple charging. This article reviews the information that can be obtained by analyzing ionic charge state distributions in ESI MS, as well as potential pitfalls and limitations of this powerful technique. We also discuss future areas of growth with particular emphasis on applications in structural biology, biotechnology (protein-polymer conjugates), and nanomedicine.
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Cited by
Ion mobility mass spectrometry of proteins and proteinassemblies
Uetrecht, C., Rose, R. J., van Duijn, E., Lorenzen, K., & Heck, A. J. R. (2010) · Chem. Soc. Rev. · doi:10.1039/b914002f · Cited by 462
Hall, Z., Politis, A., Bush, M. F., Smith, L. J., & Robinson, C. V. (2012) · Journal of the American Chemical Society · doi:10.1021/ja2096859 · Cited by 267
Hedges, J. B., Vahidi, S., Yue, X., & Konermann, L. (2013) · Analytical Chemistry · doi:10.1021/ac401020s · Cited by 109
Muneeruddin, K., Nazzaro, M., & Kaltashov, I. A. (2015) · Analytical Chemistry · doi:10.1021/acs.analchem.5b02982 · Cited by 98
Self-citationWongkongkathep, P., Han, J. Y., Choi, T. S., Yin, S., Kim, H. I., & Loo, J. A. (2018) · Journal of the American Society for Mass Spectrometry · doi:10.1007/s13361-018-2002-2 · Cited by 71
Metadata
- Authors
- Kaltashov, I. A., & Abzalimov, R. R.
- Venue
- Journal of the American Society for Mass Spectrometry
- Publisher
- American Chemical Society (ACS)
- Published
- 2008-09-01
- Volume
- 19
- Issue
- 9
- Pages
- 1239-1246
- ISSN
- 1044-0305 (ISSN-L)
- OpenAlex
- W1977536637
- Cited by
- 170
- References
- 0
- FWCI
- 7.61
- Type
- journal article
- Language
- en
- Open access
- closed
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- Kaltashov, I. A., & Abzalimov, R. R. (2008). Do ionic charges in ESI MS provide useful information on macromolecular structure? Journal of the American Society for Mass Spectrometry. https://doi.org/10.1016/j.jasms.2008.05.018
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