Native Top-Down Mass Spectrometry and Ion Mobility MS for Characterizing the Cobalt and Manganese Metal Binding of α-Synuclein Protein

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Metal-triggered Structural Transformations, Aggregation, and Fibrillation of Human α-Synuclein

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Evidence for a Partially Folded Intermediate in α-Synuclein Fibril Formation

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The power of ion mobility-mass spectrometry for structural characterization and the study of conformational dynamics

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Collision Cross Sections of Proteins and Their Complexes: A Calibration Framework and Database for Gas-Phase Structural Biology

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Membrane proteins bind lipids selectively to modulate their structure and function

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Molecular-level secondary structure, polymorphism, and dynamics of full-length α-synuclein fibrils studied by solid-state NMR

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Structure of the toxic core of α-synuclein from invisible crystals

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A Role for α-Synuclein in the Regulation of Dopamine Biosynthesis

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The fold of α-synuclein fibrils

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A Protein-Chameleon: Conformational Plasticity of α-Synuclein, a Disordered Protein Involved in Neurodegenerative Disorders

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α-Synuclein assembles into higher-order multimers upon membrane binding to promote SNARE complex formation

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Structural characterization of copper(II) binding to α-synuclein: Insights into the bioinorganic chemistry of Parkinson's disease

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Interaction of α-Synuclein with Divalent Metal Ions Reveals Key Differences: A Link between Structure, Binding Specificity and Fibrillation Enhancement

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Structure of membrane-bound α-synuclein studied by site-directed spin labeling

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Structural analysis of intrinsically disordered proteins by small-angle X-ray scattering

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Extending Top-Down Mass Spectrometry to Proteins with Masses Greater Than 200 Kilodaltons

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Curcumin Modulates α-Synuclein Aggregation and Toxicity

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Primary Sequence Information from Intact Proteins by Electrospray Ionization Tandem Mass Spectrometry

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Charge-State Dependent Compaction and Dissociation of Protein Complexes: Insights from Ion Mobility and Molecular Dynamics

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Amazing Stability of the Arginine−Phosphate Electrostatic Interaction

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An integrated native mass spectrometry and top-down proteomics method that connects sequence to structure and function of macromolecular complexes

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Identification of the facile gas-phase cleavage of the Asp-Pro and Asp-Xxx peptide bonds in matrix-assisted laser desorption time-of-flight mass spectrometry

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Investigation of α-Synuclein Fibril Structure by Site-directed Spin Labeling

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Impact of N-Terminal Acetylation of α-Synuclein on Its Random Coil and Lipid Binding Properties

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α-Synuclein structure, posttranslational modification and alternative splicing as aggregation enhancers

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Top-Down ESI-ECD-FT-ICR Mass Spectrometry Localizes Noncovalent Protein-Ligand Binding Sites

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Ion Mobility Analysis of Molecular Dynamics

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Site-Specific Interactions of Cu(II) with α and β-Synuclein: Bridging the Molecular Gap between Metal Binding and Aggregation

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Do ionic charges in ESI MS provide useful information on macromolecular structure?

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α‐Synuclein regulation of the dopaminergic transporter: a possible role in the pathogenesis of Parkinson's disease

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Do Charge State Signatures Guarantee Protein Conformations?

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Gas-Phase Unfolding and Disassembly Reveals Stability Differences in Ligand-Bound Multiprotein Complexes

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A Novel “Molecular Tweezer” Inhibitor of α-Synuclein Neurotoxicity in Vitro and in Vivo

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N-Alpha-Acetylation of α-Synuclein Increases Its Helical Folding Propensity, GM1 Binding Specificity and Resistance to Aggregation

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Conformational Behavior of Human α-Synuclein is Modulated by Familial Parkinson’s Disease Point Mutations A30P and A53T

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Comparison of Structure and Dynamics of Micelle-bound Human α-Synuclein and Parkinson Disease Variants

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α-Synuclein: Stable compact and extended monomeric structures and pH dependence of dimer formation

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What Protein Charging (and Supercharging) Reveal about the Mechanism of Electrospray Ionization

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Structural insights on physiological functions and pathological effects of ±‐synuclein

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Residual Structure, Backbone Dynamics, and Interactions within the Synuclein Family

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Characterization of Native Protein Complexes Using Ultraviolet Photodissociation Mass Spectrometry

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Bioinorganic chemistry of copper coordination to alpha-synuclein: Relevance to Parkinson's disease

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Top-down mass spectrometry of supercharged native protein–ligand complexes

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Coordination Features and Affinity of the Cu2+ Site in the α-Synuclein Protein of Parkinson’s Disease

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Native Top-Down Electrospray Ionization-Mass Spectrometry of 158 kDa Protein Complex by High-Resolution Fourier Transform Ion Cyclotron Resonance Mass Spectrometry

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NMR mapping of copper binding sites in alpha-synuclein

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Molecular Basis for Preventing α-Synuclein Aggregation by a Molecular Tweezer

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A Revised Picture of the Cu(II)−α-Synuclein Complex: The Role of N-Terminal Acetylation

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Elucidating the site of protein-ATP binding by top-down mass spectrometry

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Revealing Ligand Binding Sites and Quantifying Subunit Variants of Noncovalent Protein Complexes in a Single Native Top-Down FTICR MS Experiment

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Pathophysiology of synuclein aggregation in Lewy body disease

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Collisionally activated dissociation and tandem mass spectrometry of intact hemoglobin β-chain variant proteins with electrospray ionization

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Structural Characterization of Native Proteins and Protein Complexes by Electron Ionization Dissociation-Mass Spectrometry

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Metal binding to alpha-synuclein peptides and its contribution to toxicity

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Reflections on Charge State Distributions, Protein Structure, and the Mystical Mechanism of Electrospray Ionization

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Structures of segments of α‐synuclein fused to maltose‐binding protein suggest intermediate states during amyloid formation

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Compact conformations of α‐synuclein induced by alcohols and copper

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Coordination of Copper to the Membrane-Bound Form of α-Synuclein

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Charge state dependent fragmentation of gaseous α-synuclein cations via ion trap and beam-type collisional activation

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Supramolecular Modulation of Structural Polymorphism in Pathogenic α‐Synuclein Fibrils Using Copper(II) Coordination

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Binding of Dopamine to Alpha-Synuclein is Mediated by Specific Conformational States

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Peculiarities of Copper Binding to α-Synuclein

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Probing Conformational Change of Intrinsically Disordered α-Synuclein to Helical Structures by Distinctive Regional Interactions with Lipid Membranes

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Surface Induced Dissociation Coupled with High Resolution Mass Spectrometry Unveils Heterogeneity of a 211 kDa Multicopper Oxidase Protein Complex

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Molecular Understanding of Copper and Iron Interaction with α-Synuclein by Fluorescence Analysis

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Effects of Multidentate Metal Interactions on the Structure of Collisionally Activated Proteins: Insights from Ion Mobility Spectrometry and Molecular Dynamics Simulations

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Extent of N-terminus exposure of monomeric alpha-synuclein determines its aggregation propensity

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Top-down proteomics: challenges, innovations, and applications in basic and clinical research

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Higher-order structural characterisation of native proteins and complexes by top-down mass spectrometry

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Molecular Targets of Manganese-Induced Neurotoxicity: A Five-Year Update

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Top or Middle? Up or Down? Toward a Standard Lexicon for Protein Top-Down and Allied Mass Spectrometry Approaches

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Ion Activation Methods for Peptides and Proteins

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Native top-down mass spectrometry provides insights into the copper centers of membrane-bound methane monooxygenase

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Surface-Induced Dissociation: An Effective Method for Characterization of Protein Quaternary Structure

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Metal ions shape α-synuclein

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Influence of heavy metals in Parkinson’s disease: an overview

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Native top‐down mass spectrometry for higher‐order structural characterization of proteins and complexes

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Metal Ion Binding to the Amyloid β Monomer Studied by Native Top-Down FTICR Mass Spectrometry

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Native Top-Down Mass Spectrometry and Ion Mobility Spectrometry of the Interaction of Tau Protein with a Molecular Tweezer Assembly Modulator

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Exploring the structure and dynamics of macromolecular complexes by native mass spectrometry

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Standard Proteoforms and Their Complexes for Native Mass Spectrometry

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Structural Proteomics Methods to Interrogate the Conformations and Dynamics of Intrinsically Disordered Proteins

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Internal Fragments Generated by Electron Ionization Dissociation Enhance Protein Top-Down Mass Spectrometry

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Native LC–MS for capturing quality attributes of biopharmaceuticals on the intact protein level

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Structural mass spectrometry comes of age: new insight into protein structure, function and interactions

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Taking Charge: Metal Ions Accelerate Amyloid Aggregation in Sequence Variants of α-Synuclein

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Using mass spectrometry‐based methods to understand amyloid formation and inhibition of alpha‐synuclein and amyloid beta

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Three‐repeat and four‐repeat tau isoforms form different oligomers

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Emerging Approaches to Investigate the Influence of Transition Metals in the Proteinopathies

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Roles, Characteristics, and Analysis of Intrinsically Disordered Proteins: A Minireview

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Dissecting the structural heterogeneity of proteins by native mass spectrometry

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Structure and dynamics of endogenous cardiac troponin complex in human heart tissue captured by native nanoproteomics

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Native Mass Spectrometry at the Convergence of Structural Biology and Compositional Proteomics

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Structural Evaluation of Protein/Metal Complexes via Native Electrospray Ultraviolet Photodissociation Mass Spectrometry

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Neurodegenerative Proteinopathies in the Proteoform Spectrum—Tools and Challenges

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Elusive structural changes of New Delhi metallo-β-lactamase revealed by ultraviolet photodissociation mass spectrometry

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An Update Overview on Mechanistic Data and Biomarker Levels in Cobalt and Chromium-Induced Neurodegenerative Diseases

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Application of native mass spectrometry in studying intrinsically disordered proteins: A special focus on neurodegenerative diseases

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Infrared Photoactivation Enables Improved Native Top-Down Mass Spectrometry of Transmembrane Proteins

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Mass Spectrometry-Based Structural Proteomics for Metal Ion/Protein Binding Studies

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Characterization of the metal status of natively purified alpha-synuclein from human blood, brain tissue, or recombinant sources using size exclusion ICP-MS reveals no significant binding of Cu, Fe or Zn

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Ion–Ion Charge Reduction Addresses Multiple Challenges Common to Denaturing Intact Mass Analysis

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Top/Middle-Down Characterization of α-Synuclein Glycoforms

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Coupling 193 nm Ultraviolet Photodissociation and Ion Mobility for Sequence Characterization of Conformationally-Selected Peptides

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Selective and sensitive Detection of Cu2+ in aqueous solution based on cation exchange by Metal−Organic framework TMU-16 as a fluorescent sensor

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Characterization of Molecular Tweezer Binding on α-Synuclein with Native Top-Down Mass Spectrometry and Ion Mobility-Mass Spectrometry Reveals a Mechanism for Aggregation Inhibition

Lantz, C., Lopez, J., Goring, A. K., Zenaidee, M. A., Biggs, K. E., Whitelegge, J. P., Loo, R. R. O., Klärner, F., Schrader, T. H., Bitan, G., et al. (2023) · Journal of the American Society for Mass Spectrometry · doi:10.1021/jasms.3c00281 · Cited by 17 · see citing works

Reassembling protein complexes after controlled disassembly by top-down mass spectrometry in native mode

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Techniques and Strategies for Potential Protein Target Discovery and Active Pharmaceutical Molecule Screening in a Pandemic

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Rapid desalting during electrospray ionization mass spectrometry for investigating protein-ligand interactions in the presence of concentrated salts

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Zn 2 + Binding Shifts the Conformational Ensemble of α-Synuclein Monomers toward Accelerated Amyloid Formation

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α-Synuclein condensation in synaptic vesicle function and synucleinopathies

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Depicting Conformational Ensembles of α-Synuclein by Single Molecule Force Spectroscopy and Native Mass Spectroscopy

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Characterizing metal–biomolecule interactions by mass spectrometry

Janisse, S. E., Fernandez, R. L., & Heffern, M. C. (2023) · Trends in Biochemical Sciences · doi:10.1016/j.tibs.2023.06.006 · Cited by 11 · see citing works

A Method for Metal/Protein Stoichiometry Determination Using Thin-Film Energy Dispersive X-ray Fluorescence Spectroscopy

Fruncillo, S., Trande, M., Blanford, C. F., Astegno, A., & Wong, L. S. (2019) · Analytical Chemistry · doi:10.1021/acs.analchem.9b03319 · Cited by 11 · see citing works

Self-packed size-exclusion columns enable versatile high-throughput native, top-down, and ion mobility-mass spectrometry studies on proteins and complexes

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Gas‐phase conformations of intrinsically disordered proteins and their complexes with ligands: Kinetically trapped states during transfer from solution to the gas phase

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Determination of ultra-trace metal-protein interactions in co-formulated monoclonal antibody drug product by SEC-ICP-MS

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In-silico tuning of the nano-bio interface by molecular dynamics method: Amyloid beta targeting with two-dimensional metal-organic frameworks

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Charge site manipulation to enhance top‐down fragmentation efficiency

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Panda-UV Unlocks Deeper Protein Characterization with Internal Fragments in Ultraviolet Photodissociation Mass Spectrometry

Zhu, Y., Liu, Z., Liu, J., Zhao, H., Feng, R., Shu, K., Wang, F., & Chang, C. (2024) · Analytical Chemistry · doi:10.1021/acs.analchem.4c00253 · Cited by 5 · see citing works

Ion Mobility-Mass Spectrometry to Evaluate the Effects of Protein Modification or Small Molecule Binding on Protein Dynamics

Tomlinson, L. J., & Eyers, C. E. (2019) · Methods in molecular biology · doi:10.1007/978-1-0716-0030-6_11 · Cited by 5 · see citing works

Extent of N-terminus exposure by altered long-range interactions of monomeric alpha-synuclein determines its aggregation propensityPreprint

Stephens, A. D., Zacharopoulou, M., Moons, R., Fusco, G., Seetaloo, N., Chiki, A., Hooper, P. J., Mela, I., Lashuel, H. A., Phillips, J. J., et al. (2019) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/740241 · Cited by 5 · see citing works

Nanopipettes Enable Native Mass Spectrometry Studies of the Intrinsically Disordered Protein α-Synuclein in Biochemical Buffers

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A water-soluble manganese(II) octanediaoate/phenanthroline complex acts as an antioxidant and attenuates alpha-synuclein toxicity

Queiroz, D. D., Ribeiro, T. D. P., Gonçalves, J. M., Mattos, L. M. M., Gerhardt, E., de Freitas, J. A., Palhano, F. L., Frasés, S., Pinheiro, A. S., McCann, M., et al. (2022) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2022.166475 · Cited by 4 · see citing works

Tracking Inhibition of Human Small C-Terminal Domain Phosphatase 1 Using 193 nm Ultraviolet Photodissociation Mass Spectrometry

Escobar, E. E., Yang, W., Lanzillotti, M. B., Juetten, K. J., Shields, S., Siegel, D. R., Zhang, Y., & Brodbelt, J. S. (2024) · Journal of the American Society for Mass Spectrometry · doi:10.1021/jasms.4c00098 · Cited by 3 · see citing works

Current proteomics methods applicable to dissecting the DNA damage response

Muralidharan, M., Krogan, N. J., Bouhaddou, M., & Kim, M. (2023) · NAR Cancer · doi:10.1093/narcan/zcad020 · Cited by 3 · see citing works

Top-Down Proteoform Analysis by 2D MS with Quadrupolar Detection

Polák, M., Palasser, M., Kádek, A., Kavan, D., Wootton, C. A., Delsuc, M., Breuker, K., Novák, P., & van Agthoven, M. A. (2023) · Analytical Chemistry · doi:10.1021/acs.analchem.3c02225 · Cited by 3 · see citing works

Structural Diversity of Di-Metalized Arginine Evidenced by Infrared Multiple Photon Dissociation (IRMPD) Spectroscopy in the Gas Phase

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Removal of Toxic Metabolites—Chelation: Manganese Disorders

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Resolving metal binding properties within subunits of a multimeric enzyme Mnx by surface induced dissociation and native ion mobility mass spectrometry

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Buffer-dependent conformational dynamics of α-synuclein revealed by nanopipette electrospray ionisation ion mobility mass spectrometryPreprint

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Structure and dynamics of endogenous protein complexes in human heart tissue captured by native nanoproteomicsPreprint

Chapman, E. A., Roberts, D. S., Tiambeng, T. N., Andrews, J., Wang, M., Reasoner, E. A., Melby, J. A., Li, B. H., Kim, D., Alpert, A. J., et al. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.06.13.544817

Structural domain plasticity drives Zn( ii ) distribution and buffering in metallothionein-3

Peris‐Díaz, M. D., Ebberink, E. H. T. M., Fiala, J., Heck, A. J. R., & Krężel, A. (2026) · Chemical Communications · doi:10.1039/d6cc00567e

Hyphenated Mass Spectrometry-Based Strategies for Characterizing Oligomers of α-Synuclein in Parkinson’s Disease

Sadighi, R., Istrati, A., Karijodikoro, S., Scheefhals, G. A. P. H., Baerenfaenger, M., & Rijs, A. M. (2026) · ACS Central Science · doi:10.1021/acscentsci.6c00514

Cumulative and Interactive Effects of Heavy Metal Mixtures Across Neurodegenerative Diseases: A Comparative Review of Alzheimer, Parkinson, Amyotrophic Lateral Sclerosis and Multiple Sclerosis

Mitu, I., Caba, I.-C., & Macovei, I. (2026) · Journal of Xenobiotics · doi:10.3390/jox16050174

Influence of Temperature and Osmolytes on Conformational Dynamics of Alpha Synuclein

Hampton, J., Lynch, C., Rider, R. L., Lantz, C., Xi, Z., & Russell, D. H. (2026) · The Journal of Physical Chemistry B · doi:10.1021/acs.jpcb.6c04859

Keeping It Native: Non‐Denaturing Approaches to Top‐Down Protein Mass Spectrometry

Xiao, M., Maciel, E. V. S., Lermyte, F., & Skinner, O. S. (2026) · Mass Spectrometry Reviews · doi:10.1002/mas.70050

Top-Down Mass Spectrometry Characterization of Protein-Ligand Complexes Important to Neurodegenerative Diseases

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Determining the Location of the α-Synuclein Dimer Interface Using Native Top-Down Fragmentation and Isotope Depletion-Mass Spectrometry

Jeacock, K., Chappard, A., Gallagher, K. J., Mackay, C. L., Kilgour, D. P. A., Horrocks, M. H., Kunath, T., & Clarke, D. J. (2023) · Journal of the American Society for Mass Spectrometry · doi:10.1021/jasms.2c00339 · Cited by 13 · see citing works

Investigating protein conformational ensembles by native mass spectrometry and complementary biophysical techniques—the case of α-synuclein

Brocca, S., Ponzini, E., Santambrogio, C., & Grandori, R. (2026) · Frontiers in Biophysics · doi:10.3389/frbis.2026.1887194

Metal ions shape α-synuclein

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Investigating protein structure by top-down native protein mass spectrometry

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