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The roles of plant proteases and protease inhibitors in drought response: a review

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FIGNL1 Promotes Hepatocellular Carcinoma Formation via Remodeling ECM-receptor Interaction Pathway Mediated by HMMR

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Proteomics, phylogenetics, and coexpression analyses indicate novel interactions in the plastid CLP chaperone-protease system

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The CLP and PREP protease systems coordinate maturation and degradation of the chloroplast proteome in Arabidopsis thaliana

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Functions of autophagy in chloroplast protein degradation and homeostasis

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Comparative genomics of the proteostasis network in extreme acidophiles

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ClpP Peptidase as a Plausible Target for the Discovery of Novel Antibiotics

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Knock-sideways by inducible ER retrieval enables a unique approach for studying Plasmodium- secreted proteins

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Proteolytic regulation of mitochondrial oxidative phosphorylation components in plants

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Acyldepsipeptide Analogues: A Future Generation Antibiotics for Tuberculosis Treatment

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Cyanoglobule lipid droplets are a stress-responsive metabolic compartment of cyanobacteria and the progenitor of plant plastoglobules

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Chemicals Affecting Cyanobacterial Poly(3-hydroxybutyrate) Accumulation: 2-Phenylethanol Treatment Combined with Nitrogen Deprivation Synergistically Enhanced Poly(3-hydroxybutyrate) Storage in Synechocystis sp. PCC6803 and Anabaena sp. TISTR8076

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Mutant noxy8 exposes functional specificities between the chloroplast chaperones CLPC1 and CLPC2 in the response to organelle stress and plant defence

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To Die or Not to Die—Regulated Cell Death and Survival in Cyanobacteria

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ATAD3 Proteins: Unique Mitochondrial Proteins Essential for Life in Diverse Eukaryotic Lineages

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Chemodiverse cell system responses to UV in an algal sister of land plants

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Protein–protein interaction techniques to investigate post-translational regulation of carotenogenesis

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Uvr motifs regulate the chloroplast Clp chaperone–protease system

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Silencing an ATP-Dependent Caseinolytic Protease Proteolytic Subunit Gene Enhances the Resistance of Rice to Nilaparvata lugens

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Proteomic analysis of metabolic adaptation in a unicellular cyanobacterium during light-dark cycles and nitrogen fixation

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Environmental Proteomics Elucidates Phototrophic Biofilm Responses to Ornamental Lighting on Stone-built Heritage

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ClpS Directs Degradation of N‐Degron Substrates With Primary Destabilizing Residues in Mycolicibacterium smegmatis

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DUF4297 and HerA form abortosome to mediate bacterial immunity against phage infection

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KPNB1 modulates the Machado–Joseph disease protein ataxin-3 through activation of the mitochondrial protease CLPP

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Knock-sideways by inducible ER retrieval enables a novel approach for studying Plasmodium secreted proteinsPreprint

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Exogenous application of γ-aminobutyric acid alleviates temperature stress in mungbean (Vigna radiata) and its wild non-progenitor (Vigna glabrescens) by regulating heat shock protein genes

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Silencing of a mannitol transport gene in Phelipanche aegyptiaca by the tobacco rattle virus system reduces the parasite germination on the host root

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The chloroplast protease system degrades stromal DUF760-1 and DUF760-2 domain-containing proteins at different rates

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Cell splitting in Staphylococcus aureus is controlled by an adaptor protein facilitating degradation of a peptidoglycan hydrolase

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Small-molecule inhibitors targeting prokaryotic ClpQ protease in Plasmodium display anti-malarial efficacies against blood and liver stagesPreprint

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Interactome Analysis of ClpX Reveals Its Regulatory Role in Metabolism and Photosynthesis in Cyanobacteria

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MecA : A Multifunctional ClpP ‐Dependent and Independent Regulator in Gram‐Positive Bacteria

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A chaperonin complex regulates organelle proteostasis in malaria parasites

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Caseinolytic Protease P: A Therapeutic Nexus in Infection, Inflammation, and Immunity

Sonak, S. S., Ishwarkar, S., Nimbarte, C., & Nimbarte, V. D. (2025) · Critical Reviews in Immunology · doi:10.1615/critrevimmunol.2025059878 · Cited by 2 · see citing works

Photoautotrophic Growth and the Transcriptome of the Halotolerant Model Microalga Dunaliella salina MCC43 Under Salt Stress

Singh, S. P., Singh, P., Prasad, N., Singh, S., Singh, A., Singh, P. K., Singh, A. K., Rath, D., & Asthana, R. K. (2025) · Physiologia Plantarum · doi:10.1111/ppl.70545 · Cited by 2 · see citing works

Molecular dynamic simulations to assess the structural variability of ClpV from Enterobacter cloacae

Motiwala, T., Nyide, B., & Khoza, T. (2025) · Frontiers in Bioinformatics · doi:10.3389/fbinf.2025.1498916 · Cited by 2 · see citing works

Molecular determinants of protein half-life in chloroplasts with focus on the Clp protease system

Winckler, L. I., & Dißmeyer, N. (2023) · Biological Chemistry · doi:10.1515/hsz-2022-0320 · Cited by 3 · see citing works

Stromal DUF760-1 and DUF760-2 proteins are degraded by the chloroplast Clp protease system but have very different half-livesPreprint

Yuan, B., & van Wijk, K. J. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.03.10.584298 · Cited by 2 · see citing works

Cyanobacteria as a Photosynthetic Chassis for Metabolic Pathway Engineering with Heterologous Gene Expression

Walshe, J., & Saha, S. K. (2026) · Current Issues in Molecular Biology · doi:10.3390/cimb48060638 · Cited by 1 · see citing works

Recent advance on the physiological functions of proteases in chloroplast

Cheng, Y., Su, J., Jiao, Q., Jia, T., & Hu, X. (2025) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2025.151813 · Cited by 1 · see citing works

Identification of Potent Modulators of Human Caseinolytic Protease P for the Treatment of Hepatocellular Carcinoma: Molecular Docking, Density Functional Theory Calculation, Molecular Dynamic Simulation Studies, and In vitro Validation

Wang, C., Sha, M., Gong, W., Sun, Z., Xu, D., Wu, D., & Ji, H. (2025) · Biomedical and Biotechnology Research Journal (BBRJ) · doi:10.4103/bbrj.bbrj_288_25 · Cited by 1 · see citing works

Pan-NLR gene family analyses decipher evolutionary dynamics, population diversity, and potential disease resistance genes in cucumber

Zhang, B., & Deng, Y. (2026) · BMC Plant Biology · doi:10.1186/s12870-026-08208-3 · Cited by 1 · see citing works

A fungal nuclease effector subverts the chloroplast genome and triggers cell death to promote infection

Wang, J., Liu, X., Wu, X. W., Hu, Z., Ji, C., Su, L., Zhang, X., Chen, C., Liu, J., Hu, J., et al. (2026) · Nature Plants · doi:10.1038/s41477-026-02276-x · Cited by 1 · see citing works

AAA + protein unfoldases—the Moirai of the proteome

Azinas, S., & Carroni, M. (2026) · FEBS Letters · doi:10.1002/1873-3468.70348 · Cited by 1 · see citing works

Proteomic Analysis of Unicellular Cyanobacterium Crocosphaera subtropica ATCC 51142 under Extended Light or Dark Growth

Panda, P., Giri, S. J., Sherman, L. A., Kihara, D., & Aryal, U. K. (2025) · Journal of Proteome Research · doi:10.1021/acs.jproteome.4c00439 · Cited by 1 · see citing works

Proteomic changes orchestrate metabolic acclimation of a unicellular diazotrophic cyanobacterium during light-dark cycle and nitrogen fixation statesPreprint

Panda, P., Giri, S. J., Sherman, L. A., Kihara, D., & Aryal, U. K. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.07.30.605809 · Cited by 1 · see citing works

cpSRP54 and FtsH cooperate thylakoid membrane associated proteostasis during de-etiolation in Arabidopsis thalianaPreprint

Yang, L., Li, B., Wang, X., Wei, J., Wang, P., Zhao, J. Y., Yu, F., & Qi, Y. (2022) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2022.12.01.518768

Light responses in cyanobacteria

Li, X., Shi, Z., & Wang, Q. (2023) · Elsevier eBooks · doi:10.1016/b978-0-323-98391-4.00014-9

Environmental Proteomics Elucidate Phototrophic Biofilm Responses to Ornamental Lighting on Stone-Built HeritagePreprint

Méndez, A., Sanmartín, P., Balboa, S., & Trueba-Santiso, A. (2024) · SSRN Electronic Journal · doi:10.2139/ssrn.4839343

ClpS directs degradation of primary N-end rule substrates in Mycolicibacterium smegmatisPreprint

Presloid, C. J., Jiang, J., Kandel, P., Anderson, H. R., Beardslee, P. C., Swayne, T. M., & Schmitz, K. R. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.06.12.598358

ProEnd: a comprehensive database for identifying HbYX motif-containing proteins across the tree of life

Salcedo-Tacuma, D., Howells, G., Mchose, C., Gutierrez-Diaz, A., Schupp, J. E., & Smith, D. M. (2024) · BMC Genomics · doi:10.1186/s12864-024-10864-4

Plastomic studies inform the mechanisms of edaphic adaptation in North American species in the tribe Thelypodieae (Brassicaceae)

Daundasekara, K. C., Garza, E. R., & Pepper, A. E. (2025) · American Journal of Botany · doi:10.1002/ajb2.70071

Computational Repurposing and Phytochemical Screening of Inhibitors Against ClpK from Klebsiella pneumoniaePreprint

Ballim, T., & Khoza, T. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.11.28.691150

ClpK as a Chaperone Hub: Computational Exploration of its Protein Interaction LandscapePreprint

Ballim, T., Achilonu, I., & Khoza, T. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.11.28.691151

Loss of FRIENDLY MITOCHONDRIA (FMT) Restores Chloroplast Proteostasis via Inter-organelle CompensationPreprint

Kim, J., Na, C., Routray, P., Bae, N., Kim, H., Kim, D. B., Kim, D. B., Son, N., Nasim, Z., Lee, R., et al. (2026) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2026.02.14.705898

Expression landscape of metabolic engineering enzymes in cyanobacteriaPreprint

Medipally, H., Karlsson, A., Dheer, A., Hudson, E. P., & Englund, E. (2026) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2026.04.08.717203

Dual Cytoplasmic and Chloroplastic Mechanisms Fine‐Tune Chloroplast Division through ARC3 Protein Stability

Yuan, Y., Xiang, D., Li, R., Yue, Z., Wang, Z., & Hu, H. (2026) · Advanced Science · doi:10.1002/advs.202523660

Unveiling SNPs diversity and Genetic Control of Fodder Quality in forage Sorghum using Genome-Wide Association StudiesPreprint

Behera, P. P., & Sarma, R. N. (2026) · Research Square · doi:10.21203/rs.3.rs-9907438/v1

ClpC1-dependent iron homeostasis underlies mycobacterial defense against oxygen-driven Fenton reaction during reactivation

Chi, M., Zheng, Y., Zheng, W., Chen, Y., Zhou, B., Chen, J., Bai, J., Di, Y., & Zhang, X. (2026) · Microbiology Spectrum · doi:10.1128/spectrum.00496-26

Chloroplast proteostasis: coupling chlorophyll and carotenoid metabolism with chlorophyll-binding protein homeostasis in plants

Fu, D., Zhao, C., Huang, X., & Wang, P. (2026) · Journal of Experimental Botany · doi:10.1093/jxb/erag307

The chloroplast CLP chaperone-protease system controls the steady-state abundance of the singlet oxygen sensors EXCUTER 1 and 2Preprint

Ravenburg, C. M., Routray, P., Bouchnak, I., Yuan, B., Julkowska, M., & van Wijk, K. J. (2026) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2026.08.05.743032

Assessment of Bacterial N-Degron Proteolysis by a Dual-Fluorescence Reporter

Kandel, P., Beardslee, P. C., & Schmitz, K. R. (2026) · Methods in molecular biology · doi:10.1007/978-1-0716-5508-5_17

The small helix–loop–helix protein NsrC is a regulator of phycobilisome biosynthesis

Li, W., Liu, Q., Fan, S., Chen, Z., Zhang, J., & Zhao, G. (2026) · The Plant Cell · doi:10.1093/plcell/koag249

Cyanobacteria: A sustainable platform for high-value biopharmaceutical protein production

Majhi, B. K. (2026) · Journal of Pharmaceutical Analysis · doi:10.1016/j.jpha.2026.101807

Structural and functional studies of the ATP-dependent Clp proteases in cyanobacteria

Ståhlberg, F. M. (2014) · Gothenburg University Publications Electronic Archive (Gothenburg University)

Biochemical studies of the essential Clp protease in cyanobacteria and its associated adaptor proteins

Tryggvesson, A. (2014) · Gothenburg University Publications Electronic Archive (Gothenburg University)

Structural Principles of Substrate Recognition and Unfolding by the ClpAP and ClpXP AAA+ Proteases

Kim, S. (2022) · DSpace@MIT (Massachusetts Institute of Technology)

Mini review: ATP‐dependent proteases in bacteria

Bittner, L., Arends, J., & Narberhaus, F. (2016) · Biopolymers · doi:10.1002/bip.22831 · Cited by 49 · see citing works

Communication & coordination between components of the ClpAP degradation machine

Zuromski, K. L. (2021) · DSpace@MIT (Massachusetts Institute of Technology)