Phospholipase Cγ in Toll-like receptor-mediated inflammation and innate immunity
Abstract
Among the phospholipase C (PLC) isoforms, PLCγ not only has unique structural characteristics in terms of harboring SH2 and SH3 domains but also mediates growth factor-induced signaling pathways. PLCγ isoforms are expressed in several innate immune cell types, including macrophages, natural killer cells, mast cells, and neutrophils. Stimulation of Fc receptor or integrin in innate immune cells induces PLCγ activation, which leads to phosphoinositide hydrolysis and calcium increase. The products of PLCγ activity mediate the innate immune response by regulating respiratory burst, phagocytosis, cell adhesion, and cell migration. PLCγ also regulates the inflammatory response by affecting Toll-like receptor-mediated signaling. Here, we briefly review the current understanding of the functional role of PLCγ in inflammation and innate immunity in some innate immune cell types.
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The SH3 domain binds to poly-proline motifs in adaptors and other proteins.
“The SH3 domain binds to poly-proline motifs in adaptors and other proteins [90].”
From TREM2/PLCγ2 signalling in immune cells: function, structural insight, and potential therapeutic modulation (2021) · cites this paper as [90]
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- Authors
- Bae, Y.-S., Lee, H. Y., Jung, Y. S., Lee, M., & Suh, P.-G.
- Affiliations
- Sungkyunkwan University (KR)
- Ulsan National Institute of Science and Technology (KR)
- Corresponding author
- Bae, Yoe-Sik
- Venue
- Advances in Biological Regulation
- Publisher
- Elsevier BV
- Published
- 2017-01
- Volume
- 63
- Pages
- 92-97
- ISSN
- 2212-4926 (ISSN-L)
- OpenAlex
- W2525065237
- Cited by
- 34
- References
- 9
- Citations by year
- 2026: 1 · 2025: 4 · 2023: 4 · 2022: 5 · 2021: 4 · 2020: 5 · 2019: 2 · 2018: 3 · 2017: 6
- FWCI
- 0.35
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- Locations
- Advances in Biological Regulation (publishedVersion)
- PubMed (publishedVersion)
- Scholarworks@UNIST (Ulsan National Institute of Science and Technology) (submittedVersion)
- Funders
- National Research Foundation of Korea
- Ministry of Science ICT and Future Planning (NRF-2015R1A2A1A10054567, NRF-2016R1A2B4013128)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein Kinase Regulation and GTPase Signaling
- Life Sciences › Immunology and Microbiology › Immunology › Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Keywords
- phospholipase C-gamma, Toll-like receptors, innate immunity, inflammation, phosphoinositide hydrolysis, calcium signaling, macrophages, natural killer cells, mast cells, neutrophils, Fc receptor signaling, integrin signaling, respiratory burst, phagocytosis, cell adhesion, cell migration
- MeSH terms
- Protein Domains, Animals, Cell Movement, Gene Expression Regulation, Humans, Immunity, Innate, Inflammation, Killer Cells, Natural, Macrophages, Mast Cells, Neutrophils, Phagocytosis, Receptors, Fc, Signal Transduction, Respiratory Burst, Toll-Like Receptors, Phospholipase C gamma
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