The regulation of insulin secretion via phosphoinositide-specific phospholipase Cβ signaling
Abstract
Phospholipase Cβ (PLCβ) is a membrane-associated enzyme activated by membrane receptors, especially G-protein coupled receptors (GPCRs). It propagates intracellular signaling by mediating phospholipid metabolism and generating key second messengers, such as inositol triphosphate and diacylglycerol, leading to intracellular Ca 2+ mobilization and activation of kinases, such as protein kinases C. In pancreatic β-cells, PLCβ-mediated signaling activated by various factors, such as free fatty acids and neuronal and hormonal ligands, has been confirmed as being involved in the regulation of insulin secretion, and PLCβs have been regarded as essential mediators for augmenting insulin secretion. In this review, we describe the physiological function of PLCβs in the regulation of glucose-stimulated insulin secretion and discuss emerging data on GPCR/PLCβ signaling that is being developed as a target for the treatment of diabetes mellitus.
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PLCβ1 has been implicated in control of neuronal function and enhancement of glucose-stimulated insulin secretion in pancreatic β-cells downstream of specific GPCRs.
“Among many roles, ubiquitously expressed PLCβ1 enzyme has been implicated in control of neuronal function and the enhancement of glucose-stimulated insulin secretion in pancreatic β-cells downstream of specific GPCRs in these different cell types [36–40].”
From Phosphatidylinositol(4,5)bisphosphate: diverse functions at the plasma membrane (2020) · cites this paper as [40]
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Role of GPR40 in fatty acid action on the β cell line INS-1E
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The Phospholipase C Isozymes and Their Regulation
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GLP-1 stimulates insulin secretion by PKC-dependent TRPM4 and TRPM5 activation
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Phosphatidylinositol(4,5)bisphosphate: diverse functions at the plasma membrane
Katan, M., & Cockcroft, S. (2020) · Essays in Biochemistry · doi:10.1042/ebc20200041 · Cited by 176 · see citing works
- Authors
- Hwang, H.-J., Jang, H.-J., Cocco, L., & Suh, P.-G.
- Affiliations
- Ulsan National Institute of Science and Technology (KR)
- University of Bologna (IT)
- Corresponding author
- Suh, Pann-Ghill
- Venue
- Advances in Biological Regulation
- Publisher
- Elsevier BV
- Published
- 2019-01
- Volume
- 71
- Pages
- 10-18
- ISSN
- 2212-4926 (ISSN-L)
- OpenAlex
- W2893745395
- Cited by
- 11
- References
- 5
- Citations by year
- 2025: 1 · 2024: 1 · 2023: 2 · 2021: 1 · 2020: 3 · 2019: 3
- FWCI
- 0.39
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Advances in Biological Regulation (publishedVersion)
- PubMed (publishedVersion)
- Archivio istituzionale della ricerca (Alma Mater Studiorum Università di Bologna) (submittedVersion)
- Scholarworks@UNIST (Ulsan National Institute of Science and Technology) (submittedVersion)
- Funders
- Ministry of Science and ICT, South Korea
- National Research Foundation
- National Research Foundation of Korea (NRF-2014M3A9D8034459, NRF-2017R1E1A1A01074510)
- Topics
- Health Sciences › Medicine › Surgery › Pancreatic function and diabetes
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein Kinase Regulation and GTPase Signaling
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Metabolism, Diabetes, and Cancer
- Keywords
- insulin secretion, pancreatic beta cells, glucose-stimulated insulin secretion, G protein-coupled receptors, inositol trisphosphate, diacylglycerol, protein kinase C, calcium mobilization, free fatty acids, diabetes mellitus
- MeSH terms
- Insulin Secretion, Animals, Calcium, Diglycerides, Glucose, Humans, Inositol Phosphates, Calcium Signaling, Receptors, G-Protein-Coupled, Phospholipase C beta
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