The DOI matches its Crossref record; 60 of the 61 references it cites were found in a registry or an index.
Small fiber neuropathy: Diagnosis, causes, and treatment
Abstract
Small fiber neuropathy, which affects the sensory Aδ and C fibers, is now a major diagnostic and therapeutic challenge. Nearly 7% of the general population have chronic neuropathic pain responsible for severe quality-of-life impairments. Awareness must therefore be raised among clinicians of the somatosensory and autonomic symptoms that can reveal small fiber neuropathy, appropriate diagnostic investigations, most common causes, and best treatment options for each patient profile. To help achieve this goal, the present review article discusses the clinical presentation of neuropathic pain and paresthesia and/or autonomic dysfunction due to involvement of nerves supplying exocrine glands and smooth muscle; normal findings from standard electrophysiological investigations; most informative diagnostic tests (epidermal nerve fiber density in a skin biopsy, laser-evoked potentials, heat- and cold-detection thresholds, electrochemical skin conductance); main causes, which consist chiefly of metabolic diseases (diabetes mellitus, glucose intolerance), dysimmunity syndromes (Sjögren's syndrome, sarcoidosis, monoclonal gammopathy), and genetic abnormalities (familial amyloidosis due to a transthyretin mutation, Fabry disease, sodium channel diseases); and the available symptomatic and etiological treatments.
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“Interestingly, cardiovascular dysautonomia and a range of other functional symptoms commonly reported in hEDS/HSD are also considered typical manifestations of small-fibre neuropathy [31].”
From Severity classes in adults with hypermobile Ehlers–Danlos syndrome/hypermobility spectrum disorders: a pilot study of 105 Italian patients (2019) · cites this paper as [31]
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Cites
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The diagnostic criteria for small fibre neuropathy: from symptoms to neuropathology
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Gain of function Na V 1.7 mutations in idiopathic small fiber neuropathy
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Surrogate Markers of Small Fiber Damage in Human Diabetic Neuropathy
Quattrini, C., Tavakoli, M., Jeziorska, M., Kallinikos, P. A., Tesfaye, S. H., Finnigan, J., Marshall, A. G., Boulton, A. J. M., Efron, N., & Malik, R. A. (2007) · Diabetes · doi:10.2337/db07-0285 · Cited by 516
A Gain-of-Function Mutation in TRPA1 Causes Familial Episodic Pain Syndrome
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Research works printed but not linked: 1
- Sene, 2010, [Small fibre neuropathy: diagnostic approach and therapeutic issues, and its association with primary Sjogren's syndrome], Rev Med Interne, 31, 677
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Basic mechanisms of peripheral nerve injury and treatment via electrical stimulation
Chu, X.-L., Song, X.-Z., Li, Q., Li, Y.-R., He, F., Gu, X.-S., & Ming, D. (2022) · Neural Regeneration Research · doi:10.4103/1673-5374.335823 · Cited by 164
Vitamin B-6-Induced Neuropathy: Exploring the Mechanisms of Pyridoxine Toxicity
Hadtstein, F., & Vrolijk, M. F. (2021) · Advances in Nutrition · doi:10.1093/advances/nmab033 · Cited by 120
Small-fiber neuropathy definition, diagnosis, and treatment
Basantsova, N. Y., Starshinova, A. A., Dori, A., Zinchenko, Y. S., Yаblonskiy, P. K., & Shoenfeld, Y. (2019) · Neurological Sciences · doi:10.1007/s10072-019-03871-x · Cited by 81
Current View of Diagnosing Small Fiber Neuropathy
Raasing, L. R. M., Vogels, O. J. M., Veltkamp, M., van Swol, C. F. P., & Grutters, J. C. (2020) · Journal of Neuromuscular Diseases · doi:10.3233/jnd-200490 · Cited by 68
Hereditary transthyretin-related amyloidosis
Finsterer, J., Iglseder, S., Wanschitz, J., Topakian, R., Löscher, W. N., & Grisold, W. (2018) · Acta Neurologica Scandinavica · doi:10.1111/ane.13035 · Cited by 64
Metadata
- Authors
- Sène, D.
- Affiliations
- Assistance Publique – Hôpitaux de Paris (FR)
- Corresponding author
- Sène, Damien
- ORCID
- Sène, Damien
- Venue
- Joint Bone Spine
- Publisher
- Elsevier BV
- Published
- 2018-10
- Volume
- 85
- Issue
- 5
- Pages
- 553-559
- ISSN
- 1297-319X (ISSN-L)
- OpenAlex
- W2770269036
- Cited by
- 113
- References
- 61
- Citations by year
- 2026: 6 · 2025: 11 · 2024: 16 · 2023: 18 · 2022: 22 · 2021: 16 · 2020: 15 · 2019: 7 · 2018: 2
- FWCI
- 0.81
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Joint Bone Spine (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Physiology (medical) › Pain Mechanisms and Treatments
- Health Sciences › Medicine › Clinical Neurology › Peripheral Neuropathies and Disorders
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Hereditary Neurological Disorders
- Keywords
- small fiber neuropathy, chronic neuropathic pain, epidermal nerve fiber density, laser-evoked potentials, electrochemical skin conductance, autonomic dysfunction, paresthesia, diabetes mellitus, impaired glucose tolerance, Sjögren's syndrome, sarcoidosis, monoclonal gammopathy, familial amyloidosis, transthyretin mutations, Fabry disease, neuropathic pain treatment
- MeSH terms
- Small Fiber Neuropathy, Analgesics, Antidepressive Agents, Biopsy, Needle, Electromyography, Female, Humans, Immunohistochemistry, Male, Neurologic Examination, Pain Measurement, Prognosis, Sarcoidosis, Sjogren's Syndrome, Treatment Outcome, Risk Assessment, Chronic Pain
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