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Cited by 22Viral Infections and Immunology ResearchSARS-CoV-2 and COVID-19 ResearchCOVID-19 Clinical Research Studies

The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.

Acute myocarditis associated with COVID-19 vaccination: A case report

Open access

Abstract

Recently, new vaccine platforms-including mRNA vaccines for coronavirus disease 2019 (COVID-19) have been given emergency use authorization in Japan. Here, we present a rare case of myocarditis following a COVID-19 vaccine. In this case, myocarditis was confirmed by cardiac magnetic resonance imaging, endomyocardial biopsy, and troponin levels. The degree of myocardial inflammation in the endomyocardial biopsy samples was mild and the patient's clinical course was not severe. Although the pathology of myocarditis in this case was mild, further investigation would be needed. < Learning objective: Vaccination for coronavirus disease 2019 is advancing worldwide, but post-vaccination myocarditis is getting attention as a rare side effect. Although the myocarditis in this case was mild, the pathogenesis of the disease is unclear and needs to be thoroughly investigated in the vaccination.>

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Registry

Crossref · 10.1016/j.jccase.2021.11.006

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3 of 3 references verified0 citation errors · 0 not checkable

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Figures

Fig. 1 Electrocardiogram on admission. ST segment elevation was observed in the precordial leads (V3-V6, black arrow heads).
Fig. 1 Electrocardiogram on admission. ST segment elevation was observed in the precordial leads (V3-V6, black arrow heads).CC BY · PubMed Central
Fig. 2 Acute myocarditis after COVID-19 vaccination. (A) Histopathological evaluation of an endomyocardial biopsy sample from the left ventricle. Hematoxylin-eosin staining showed a small amount of infiltration of mononuclear cells. Scale bar, 100 μm. (B) Immunostaining with CD68 antibody of mononuclear cells in the endomyocardial biopsy sample. Immunohistochemistry was performed with mouse monoclonal CD68 antibody (MCA341R, BIO-RAD laboratories, Hercules, CA, USA) using the ABC kit (Vector Laboratories, Burlingame, CA, USA) according to the manufacturer's protocol. CD68-positive cells are indicated with a black arrow. Scale bar, 25 μm. (C) Cardiac MRI imaging. Short-axis view of a post-contrast image showing sub-epicardial and mid-myocardial late gadolinium enhancement (white arrow heads) in the mid-chamber inferolateral wall.
Fig. 2 Acute myocarditis after COVID-19 vaccination. (A) Histopathological evaluation of an endomyocardial biopsy sample from the left ventricle. Hematoxylin-eosin staining showed a small amount of infiltration of mononuclear cells. Scale bar, 100 μm. (B) Immunostaining with CD68 antibody of mononuclear cells in the endomyocardial biopsy sample. Immunohistochemistry was performed with mouse monoclonal CD68 antibody (MCA341R, BIO-RAD laboratories, Hercules, CA, USA) using the ABC kit (Vector Laboratories, Burlingame, CA, USA) according to the manufacturer's protocol. CD68-positive cells are indicated with a black arrow. Scale bar, 25 μm. (C) Cardiac MRI imaging. Short-axis view of a post-contrast image showing sub-epicardial and mid-myocardial late gadolinium enhancement (white arrow heads) in the mid-chamber inferolateral wall.CC BY · PubMed Central

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Citations

Cites

Research works printed but not linked: 7

  1. Zeng, 2020, First case of COVID-19 complicated with fulminant myocarditis: a case report and insights, Infection, 48, 773, 10.1007/s15010-020-01424-5 · DOI
  2. Ruan, 2020, Clinical predictors of mortality due to COVID-19 based on an analysis of data of 150 patients from Wuhan, China, Intensive Care Med, 46, 846, 10.1007/s00134-020-05991-x · DOI · Paper page
  3. Ferreira, 2018, Cardiovascular magnetic resonance in nonischemic myocardial inflammation: expert recommendations, J Am Coll Cardiol, 72, 3158, 10.1016/j.jacc.2018.09.072 · DOI · Paper page
  4. Rosner, 2021, Myocarditis temporally associated with COVID-19 vaccination, Circulation, 144, 502, 10.1161/CIRCULATIONAHA.121.055891 · DOI
  5. Muthukumar, 2021, In-depth evaluation of a case of presumed myocarditis following the second dose of COVID-19 mRNA vaccine, Circulation, 144, 487, 10.1161/CIRCULATIONAHA.121.056038 · DOI
  6. Verma, 2021, Myocarditis after Covid-19 mRNA vaccination, N Engl J Med, 385, 1332, 10.1056/NEJMc2109975 · DOI
  7. Choi, 2021, Myocarditis-induced sudden death after BNT162b2 mRNA COVID-19 vaccination in Korea: Case report focusing on histopathological findings, J Korean Med Sci, 36, e286, 10.3346/jkms.2021.36.e286 · DOI

Cited by

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Metadata

Authors
Nagasaka, T., Koitabashi, N., Ishibashi, Y., Aihara, K., Takama, N., Ohyama, Y., Yokoyama, T., & Kaneko, Y.
Affiliations
Gunma University (JP)
Corresponding author
Koitabashi, Norimichi
Venue
Journal of Cardiology Cases
Publisher
Elsevier BV
Published
2022-05
Volume
25
Issue
5
Pages
285-288
ISSN
1878-5409 (ISSN-L)
OpenAlex
W4200527736
Cited by
22
References
3
Citations by year
2025: 1 · 2024: 4 · 2023: 3 · 2022: 13
FWCI
3.52
Type
journal article
Language
en
Open access
Locations
  • Journal of Cardiology Cases (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
Funders
Japan Society for the Promotion of Science (21K08022)
Topics
  • Health Sciences › Medicine › Infectious Diseases › Viral Infections and Immunology Research
  • Health Sciences › Medicine › Infectious Diseases › SARS-CoV-2 and COVID-19 Research
  • Health Sciences › Medicine › Infectious Diseases › COVID-19 Clinical Research Studies
Keywords
acute myocarditis, COVID-19 vaccination, mRNA vaccines, vaccine adverse events, endomyocardial biopsy, cardiac magnetic resonance imaging, troponin, myocarditis, pathogenesis

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

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