Successful lung re-transplant in a patient with cepacia syndrome due to Burkholderia ambifaria
Open accessAbstract
Chronic airway inflammation and infection drive morbidity and mortality among patients with cystic fibrosis (CF). While Haemophilus influenzae and Staphylococcus aureus predominate in children, the prevalence of Pseudomonas aeruginosa increases as patients age. Other bacteria, including species within the Burkholderia cepacia complex (Bcc), are also more prevalent among adults with CF. Species within the Bcc accelerate lung function decline and can trigger development of "cepacia syndrome," both before and after lung transplantation. As a result, some centers advise against lung transplantation for Bcc-infected patients; however, little is known about the relative virulence of uncommon Bcc species. We describe a successful lung re-transplant in a patient with CF, chronic Burkholderia ambifaria airway infection, and cepacia syndrome.
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Patients with B. cepacia complex may be candidates at specialized centers that have attained satisfactory outcomes with protocols implementing newer antibiotic combinations and intense management of sinusitis.
“patients may be candidates at specialized centers that have attained satisfactory outcomes with protocols implementing newer antibiotic combinations and intense management of sinusitis.(74–77)”
From Consensus document for the selection of lung transplant candidates: An update from the International Society for Heart and Lung Transplantation. (2021) · cites this paper as [77]
The Case and Conclusions (page not provided) describe one successful re-transplant after treatment with a newer antibiotic combination and aggressive antibiotic therapy. The Introduction identifies sinuses as possible reservoirs of infection, but the paper does not describe intensive sinusitis management or establish satisfactory outcomes across specialized centers. (LLM, conf=0.88)
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Cites
Infection with Burkholderia cepacia in Cystic Fibrosis
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Impact of <i>Burkholderia</i> Infection on Lung Transplantation in Cystic Fibrosis
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Leard, L. E., Holm, A. M., Valapour, M., Glanville, A. R., Attawar, S., Aversa, M., Campos, S. V., Christon, L. M., Cypel, M., Dellgren, G., et al. (2021) · The Journal of Heart and Lung Transplantation · doi:10.1016/j.healun.2021.07.005 · Cited by 821 · see citing works
“74-77”
- Authors
- Goodlet, K. J., Nailor, M. D., Omar, A., Huang, J. L., LiPuma, J. J., Walia, R., & Tokman, S.
- Affiliations
- Midwestern University (US)
- St. Joseph's Hospital and Medical Center (US)
- University of Michigan (US)
- Corresponding author
- Tokman, Sofya
- ORCID
- Venue
- Journal of Cystic Fibrosis
- Publisher
- Elsevier BV
- Published
- 2019-01
- Volume
- 18
- Issue
- 1
- Pages
- e1-e4
- ISSN
- 1569-1993 (ISSN-L)
- OpenAlex
- W2891813746
- Semantic Scholar
- 7cbaa7a763c5868cee4141735b38207fb0f77bd9
- Cited by
- 12
- References
- 10
- Citations by year
- 2026: 1 · 2025: 1 · 2024: 1 · 2023: 2 · 2022: 2 · 2021: 3 · 2020: 2
- FWCI
- 1.31
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Journal of Cystic Fibrosis (publishedVersion)
- PubMed (publishedVersion)
- Funders
- International Society for Heart and Lung Transplantation
- Topics
- Health Sciences › Medicine › Surgery › Transplantation: Methods and Outcomes
- Health Sciences › Medicine › Epidemiology › Burkholderia infections and melioidosis
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Endocrinology › Infections and bacterial resistance
- Keywords
- Burkholderia ambifaria, Burkholderia cepacia complex, cepacia syndrome, chronic airway infection, lung transplantation, bacterial virulence
- MeSH terms
- Adult, Cystic Fibrosis, Female, Humans, Lung, Reoperation, Syndrome, Tomography, X-Ray Computed, Lung Transplantation, Bacteremia, Burkholderia, Burkholderia Infections
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