The DOI matches its Crossref record; 34 of the 34 references it cites were found in a registry or an index.
Left Ventricular Amyloid Deposition in Patients With Heart Failure and Preserved Ejection Fraction
Open accessAbstract
Objective Determine the frequency of left ventricular (LV) amyloid in heart failure with preserved ejection fraction (HFpEF). Background LV amyloid deposition can cause diastolic dysfunction and HFpEF. Methods Autopsy LV specimens from patients with ante-mortem diagnosis of HFpEF without clinically apparent amyloid (n=109) and Control subjects (n=131) were screened with sulfated alcian blue and subsequent Congo red staining with micro-dissection for mass spectrometry-based proteomics to determine amyloid type. Fibrosis was assessed with quantitative whole-field digital microscopy. Results Presence of wtTTR amyloid was associated with age at death and male sex; but the age-and sex-adjusted prevalence of wtTTR amyloid was higher in HFpEF than Control (Odds ratio 3.8, 95% confidence interval 1.5–11.3; p=0.03). Among HFpEF patients, moderate or severe interstitial wtTTR deposition, consistent with senile systemic amyloidosis as the primary etiology of HFpEF, was present in five (5%) patients (80% male), with mild interstitial and/or variable severity of intramural coronary vascular deposition in 13 (12%). While wtTTR deposition was often mild, adjusting for age and presence of HFpEF, wtTTR amyloid was associated with more fibrosis (p=0.005) and lower age, sex, and body size-adjusted heart weight (p=0.04). Conclusion Given the age- and sex-independent association of HFpEF and wtTTR deposition and an emerging understanding of the pathophysiology of the amyloidoses, the current findings support further investigation of the role of wtTTR in the pathophysiology of HFpEF.
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Cites
Trends in Prevalence and Outcome of Heart Failure with Preserved Ejection Fraction
Owan, T. E., Hodge, D. O., Herges, R. M., Jacobsen, S. J., Roger, V. L., & Redfield, M. M. (2006) · New England Journal of Medicine · doi:10.1056/nejmoa052256 · Cited by 4,191
Self-citationAntlanger, M., Aschauer, S., Kopecky, C., Hecking, M., Kovarik, J. J., Werzowa, J., Mascherbauer, J., Genser, B., Säemann, M. D., & Bonderman, D. (2017) · Kidney and Blood Pressure Research · doi:10.1159/000473868 · Cited by 2,808
Biological and Chemical Approaches to Diseases of Proteostasis Deficiency
Powers, E. T., Morimoto, R. I., Dillin, A., Kelly, J. W., & Balch, W. E. (2009) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.052308.114844 · Cited by 1,149
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Variant-Sequence Transthyretin (Isoleucine 122) in Late-Onset Cardiac Amyloidosis in Black Americans
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Self-citationFrequency and distribution of senile cardiovascular amyloid
Cornwell, G. G., Murdoch, W. L., Kyle, R. A., Westermark, P., & Pitkänen, P. (1983) · The American Journal of Medicine · doi:10.1016/0002-9343(83)90443-6 · Cited by 483
Redox Signaling in Cardiac Physiology and Pathology
Burgoyne, J. R., Mongue-Din, H., Eaton, P., & Shah, A. M. (2012) · Circulation Research · doi:10.1161/circresaha.111.255216 · Cited by 482
Diastolic and Systolic Heart Failure Are Distinct Phenotypes Within the Heart Failure Spectrum
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Cited by
Angiotensin–Neprilysin Inhibition in Heart Failure with Preserved Ejection Fraction
Solomon, S. D., McMurray, J. J. V., Anand, I. S., Ge, J., Lam, C. S. P., Maggioni, A. P., Martinez, F., Packer, M., Pfeffer, M. A., Pieske, B., et al. (2019) · New England Journal of Medicine · doi:10.1056/nejmoa1908655 · Cited by 2,430
Self-citationEpidemiology of heart failure with preserved ejection fraction
Dunlay, S. M., Roger, V. L., & Redfield, M. M. (2017) · Nature Reviews Cardiology · doi:10.1038/nrcardio.2017.65 · Cited by 1,534
Self-citationKittleson, M. M., Maurer, M. S., Ambardekar, A. V., Bullock-Palmer, R. P., Chang, P. P., Eisen, H. J., Nair, A. P., Nativi-Nicolau, J., Ruberg, F. L., & On behalf of the American Heart Association Heart Failure and Transplantation Committee of the Council on Clinical Cardiology (2020) · Circulation · doi:10.1161/cir.0000000000000792 · Cited by 756
Evaluation and management of heart failure with preserved ejection fraction
Borlaug, B. A. (2020) · Nature Reviews Cardiology · doi:10.1038/s41569-020-0363-2 · Cited by 675
Sacubitril/Valsartan Across the Spectrum of Ejection Fraction in Heart Failure
Solomon, S. D., Vaduganathan, M., L. Claggett, B., Packer, M., Zile, M., Swedberg, K., Rouleau, J., A. Pfeffer, M., Desai, A., H. Lund, L., et al. (2020) · Circulation · doi:10.1161/circulationaha.119.044586 · Cited by 551
Metadata
- Authors
- Mohammed, S. F., Mirzoyev, S. A., Edwards, W. D., Dogan, A., Grogan, D. R., Dunlay, S. M., Roger, V. L., Gertz, M. A., Dispenzieri, A., Zeldenrust, S. R., & Redfield, M. M.
- Venue
- JACC: Heart Failure
- Publisher
- Elsevier BV
- Published
- 2014-04
- Volume
- 2
- Issue
- 2
- Pages
- 113-122
- ISSN
- 2213-1779 (ISSN-L)
- OpenAlex
- W2076492105
- Cited by
- 448
- References
- 34
- FWCI
- 7.91
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Mohammed, S. F., Mirzoyev, S. A., Edwards, W. D., Dogan, A., Grogan, D. R., Dunlay, S. M., Roger, V. L., Gertz, M. A., Dispenzieri, A., Zeldenrust, S. R., & Redfield, M. M. (2014). Left Ventricular Amyloid Deposition in Patients With Heart Failure and Preserved Ejection Fraction. JACC: Heart Failure. https://doi.org/10.1016/j.jchf.2013.11.004
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