The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
Senile systemic amyloidosis affects 25% of the very aged and associates with genetic variation in alpha2‐macroglobulin and tau: A population‐based autopsy study
Open accessAbstract
BACKGROUND: Senile systemic amyloidosis (SSA) is characterized by deposition of wild-type transthyretin (TTR)-based amyloid in parenchymal organs in elderly individuals. Previously, no population-based studies have been performed on SSA. METHODS: Here we have studied the prevalence and risk factors for SSA in a Finnish autopsied population aged 85 or over, as part of the population-based Vantaa 85+ Autopsy Study (n = 256). The diagnosis of SSA was based on histological examination of myocardial samples stained with Congo red and anti-TTR immunohistochemistry. The genotype frequencies of 20 polymorphisms in 9 genes in subjects with and without SSA were compared. RESULTS: The prevalence of SSA was 25%. SSA was associated with age, myocardial infarctions, the G/G (Val/Val) genotype of the exon 24 polymorphism in the alpha2-macroglobulin (alpha2M), and the H2 haplotype of the tau gene (P-values 0.002, 0.004, 0.042, and 0.016). CONCLUSION: This population-based study shows that SSA is very common in old individuals, affecting one-quarter of people aged over 85 years. Myocardial infarctions and variation in the genes for alpha2M and tau may be associated with SSA.
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Cites
Tau-mediated neurodegeneration in Alzheimer’s disease and related disorders
Ballatore, C., Lee, V. M.-Y., & Trojanowski, J. Q. (2007) · Nature Reviews Neuroscience · doi:10.1038/nrn2194 · Cited by 2,174
Association of an Extended Haplotype in the Tau Gene with Progressive Supranuclear Palsy
Baker, M., Litvan, I., Houlden, H., Adamson, J., Dickson, D., Perez-Tur, J., Hardy, J., Lynch, T., Bigio, E., & Hutton, M. (1999) · Human Molecular Genetics · doi:10.1093/hmg/8.4.711 · Cited by 781
Self-citationApolipoprotein E, Dementia, and Cortical Deposition of β-Amyloid Protein
Polvikoski, T., Sulkava, R., Haltia, M., Kainulainen, K., Vuorio, A., Verkkoniemi, A., Niinistö, L., Halonen, P., & Kontula, K. (1995) · New England Journal of Medicine · doi:10.1056/nejm199511093331902 · Cited by 493
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Diagnosis, Prognosis, and Therapy of Transthyretin Amyloidosis
Gertz, M. A., Benson, M. D., Dyck, P. J., Grogan, M., Coelho, T., Cruz, M., Berk, J. L., Plante-Bordeneuve, V., Schmidt, H. H. J., & Merlini, G. (2015) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2015.09.075 · Cited by 475
Left Ventricular Amyloid Deposition in Patients With Heart Failure and Preserved Ejection Fraction
Mohammed, S. F., Mirzoyev, S. A., Edwards, W. D., Dogan, A., Grogan, D. R., Dunlay, S. M., Roger, V. L., Gertz, M. A., Dispenzieri, A., Zeldenrust, S. R., et al. (2014) · JACC: Heart Failure · doi:10.1016/j.jchf.2013.11.004 · Cited by 448
Screening for Transthyretin Amyloid Cardiomyopathy in Everyday Practice
Witteles, R. M., Bokhari, S., Damy, T., Elliott, P. M., Falk, R. H., Fine, N. M., Gospodinova, M., Obici, L., Rapezzi, C., & Garcia-Pavia, P. (2019) · JACC: Heart Failure · doi:10.1016/j.jchf.2019.04.010 · Cited by 351
Prevalence of dementia disorders in the oldest-old: an autopsy study
Jellinger, K. A., & Attems, J. (2010) · Acta Neuropathologica · doi:10.1007/s00401-010-0654-5 · Cited by 276
Goto, S., Mahara, K., Beussink-Nelson, L., Ikura, H., Katsumata, Y., Endo, J., Gaggin, H. K., Shah, S. J., Itabashi, Y., MacRae, C. A., et al. (2021) · Nature Communications · doi:10.1038/s41467-021-22877-8 · Cited by 245
Metadata
- Authors
- Tanskanen, M., Peuralinna, T., Polvikoski, T., Notkola, I., Sulkava, R., Hardy, J., Singleton, A., Kiuru‐Enari, S., Paetau, A., Tienari, P. J., & Myllykangas, L.
- Venue
- Annals of Medicine
- Publisher
- Informa UK Limited
- Published
- 2008-01
- Volume
- 40
- Issue
- 3
- Pages
- 232-239
- ISSN
- 0785-3890 (ISSN-L)
- 1365-2060
- OpenAlex
- W2107491044
- Cited by
- 591
- References
- 3
- FWCI
- 2.73
- Type
- journal article
- Language
- en
- Open access
- bronze
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- CoChat. (2026). Citation check: Senile systemic amyloidosis affects 25% of the very aged and associates with genetic variation in alpha2‐macroglobulin and tau: A population‐based autopsy study. https://app.cochat.ai/papers/10.1080/07853890701842988
- The paper
- Tanskanen, M., Peuralinna, T., Polvikoski, T., Notkola, I., Sulkava, R., Hardy, J., Singleton, A., Kiuru‐Enari, S., Paetau, A., Tienari, P. J., & Myllykangas, L. (2008). Senile systemic amyloidosis affects 25% of the very aged and associates with genetic variation in alpha2‐macroglobulin and tau: A population‐based autopsy study. Annals of Medicine. https://doi.org/10.1080/07853890701842988
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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