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Simultaneous determination of cholesterol, ascorbic acid and uric acid as three essential biological compounds at a carbon paste electrode modified with copper oxide decorated reduced graphene oxide nanocomposite and ionic liquid

Karimi-Maleh, Hassan, Arotiba, Omotayo A.·2020·Journal of Colloid and Interface Science

Abstract

In this article, we report the simultaneous determination cholesterol (CL), ascorbic (AA) acid and uric acid (UA) at a carbon paste electrode (CPE) modified with copper oxide decorated reduced graphene (CuO-rGR), with 1-methyl-3-octylimidazolium tetrafluoroborate (1M3OIDTFB) as a binder. The electrode, CuO-rGR/1M3OIDTFB/CPE, showed remarkable sensitivities towards the determination of the analytes, and well defined and clearly separated oxidation peaks were obtained during their simultaneous analysis in a buffer solution at pH 7.4. The differences observed between their peaks potentials are as follows: 430 mV (between CL and AA), 270 mV (between AA and UA) and 700 mV (between CL and UA). The morphologies and structure properties of the CuO-rGR were investigated by FESEMD and EDAX methods. The CuO-rGR/1M3OIDTFB/CPE displayed linear response in the concentration ranges 0.04-300.0 μM, 0.04-240.0 μM and 0.4-400.0 μM for CL, AA and UA with the detection limits 9.0 nM, 9.0 nM and 0.08 μM, respectively. The CuO-rGR/1M3OIDTFB/CPE displayed high performance for the determination of CL, AA and UA in real samples.

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Metadata

Authors
Karimi-Maleh, H., & Arotiba, O. A.
Venue
Journal of Colloid and Interface Science
Publisher
Elsevier BV
Published
2020-02
Volume
560
Pages
208-212
ISSN
0021-9797 (ISSN-L)
OpenAlex
W2978297697
Cited by
404
References
26
FWCI
30.22
Type
journal article
Language
en
Open access
closed

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CoChat. (2026). Citation check: Simultaneous determination of cholesterol, ascorbic acid and uric acid as three essential biological compounds at a carbon paste electrode modified with copper oxide decorated reduced graphene oxide nanocomposite and ionic liquid. https://app.cochat.ai/papers/10.1016/j.jcis.2019.10.007
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Karimi-Maleh, H., & Arotiba, O. A. (2020). Simultaneous determination of cholesterol, ascorbic acid and uric acid as three essential biological compounds at a carbon paste electrode modified with copper oxide decorated reduced graphene oxide nanocomposite and ionic liquid. Journal of Colloid and Interface Science. https://doi.org/10.1016/j.jcis.2019.10.007

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Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.