Photothermal and enhanced chemodynamic reinforced anti-tumor therapy based on PDA@POM nanocomposites
Abstract
Chemodynamic therapy (CDT) and photothermal therapy (PTT) have both demonstrated considerable efficacy in the tumor treatment individually, owing to their non-invasive nature and excellent selectivity. However, due to the propensity of tumors for metastasis and recurrence, a singular therapeutic approach falls short of achieving optimal treatment outcomes. Polydopamine (PDA) has excellent photothermal conversion ability and polyoxometalates (POMs) possess diverse enzymatic activities. Here, we synthesized PDA@POM nanospheres comprising polydopamine-coated Tungsten-based polyoxometalate (W-POM). These nanospheres leverage dual enzymatic activities that synergistically enhance both chemodynamic and photothermal therapies for tumor treatment. The PDA-mediated PTT effect enables precise tumor cell destruction, while the W-POM nanozymes catalyzes the generation of highly toxic reactive oxygen species (ROS) from hydrogen peroxide within tumor cells through a Fenton-like reaction, which mitigates tumor hypoxia and induces tumor cell death. This synergistic photothermal catalytic therapy shows enhanced efficacy in tumor suppression, providing a promising new approach for tumor treatment.
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Subsequent near-infrared irradiation of PDA nanoparticles converts absorbed optical energy into heat, elevating local tumor temperature to cytotoxic levels (>42 °C) and inducing cancer cell death.
“Subsequent irradiation with near-infrared light enables the efficient conversion of absorbed optical energy into heat, elevating the local tumor temperature to cytotoxic levels (>42 °C) and inducing cancer cell death, while largely sparing the surrounding normal tissues from thermal damage.80”
From Polydopamine-Based Biomaterials in Oral Medicine: Applications, Mechanisms, and Translational Challenges (2026) · cites this paper as [80]
Following intravenous or local administration, PDA nanoparticles preferentially accumulate within tumor tissues via the enhanced permeability and retention (EPR) effect.
“Following intravenous or local administration, PDA nanoparticles preferentially accumulate within tumor tissues, benefiting from the enhanced permeability and retention (EPR) effect.”
From Polydopamine-Based Biomaterials in Oral Medicine: Applications, Mechanisms, and Translational Challenges (2026) · cites this paper as [80]
PDA-mediated photothermal therapy largely spares surrounding normal tissues from thermal damage.
“Subsequent irradiation with near-infrared light enables the efficient conversion of absorbed optical energy into heat, elevating the local tumor temperature to cytotoxic levels (>42 °C) and inducing cancer cell death, while largely sparing the surrounding normal tissues from thermal damage.80”
From Polydopamine-Based Biomaterials in Oral Medicine: Applications, Mechanisms, and Translational Challenges (2026) · cites this paper as [80]
In vitro antibacterial assays, simplified biofilm models, release studies, and selected animal models show that PDA-based systems can achieve biofilm inhibition, ROS regulation, localized drug release, photothermal/photodynamic antibacterial effects, and inflammation control.
“In vitro antibacterial assays, simplified biofilm models, release studies, and selected animal models show biofilm inhibition, ROS regulation, localized drug release, photothermal/photodynamic antibacterial effects, and inflammation control.”
From Polydopamine-Based Biomaterials in Oral Medicine: Applications, Mechanisms, and Translational Challenges (2026) · cites this paper as [80]
Cites
Targeting Free Radicals in Oxidative Stress-Related Human Diseases
Poprac, P., Jomova, K., Simunkova, M., Kollar, V., Rhodes, C. J., & Valko, M. (2017) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2017.04.005 · Cited by 1,107 · see citing works
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Yang, Z., Song, W., Lv, L., Zhai, S., Liu, Y., Cui, H., Li, X., Gao, F., & Chu, S. (2026) · International Journal of Nanomedicine · doi:10.2147/ijn.s611922
“80 PDA can also function as an efficient carrier for chemotherapeutic agents, enabling the construction of combined chemo–photothermal therapeutic systems.”
- Authors
- Meng, Q., Wang, W., Wang, H., Tao, Y., Anastassova, N., Sun, T., Sun, Y., & Wang, L.
- Affiliations
- Northeast Forestry University (CN)
- Bulgarian Academy of Sciences (BG)
- Harbin University of Commerce (CN)
- Harbin Institute of Technology (CN)
- Corresponding author
- Wang, Wenxin
- Wang, Haozhe
- Sun, Tiedong
- Sun, Yuan
- Wang, Lei
- Venue
- Journal of Colloid and Interface Science
- Publisher
- Elsevier BV
- Published
- 2025-01
- Volume
- 678
- Issue
- Pt C
- Pages
- 796-803
- ISSN
- 0021-9797 (ISSN-L)
- OpenAlex
- W4402578002
- Cited by
- 25
- References
- 1
- Citations by year
- 2026: 14 · 2025: 8 · 2024: 3
- FWCI
- 2.73
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- Locations
- Journal of Colloid and Interface Science (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Natural Science Foundation of China
- Topics
- Physical Sciences › Engineering › Biomedical Engineering › Nanoplatforms for cancer theranostics
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Photodynamic Therapy Research Studies
- Physical Sciences › Materials Science › Materials Chemistry › Advanced Nanomaterials in Catalysis
- Keywords
- photothermal therapy, chemodynamic therapy, polydopamine, polyoxometalates, nanozymes, Fenton-like reaction, reactive oxygen species, tumor hypoxia, nanocomposites, synergistic cancer therapy, tumor recurrence
- MeSH terms
- Polyelectrolytes, Photothermal Therapy, Polyoxometalates, Animals, Anions, Antineoplastic Agents, Cell Survival, Drug Screening Assays, Antitumor, Humans, Indoles, Particle Size, Phototherapy, Polymers, Surface Properties, Reactive Oxygen Species, Tungsten Compounds, Cell Line, Tumor, Cell Proliferation, Mice, Nanocomposites
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