Targeting Free Radicals in Oxidative Stress-Related Human Diseases

Free radicals in biology and medicine

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Oxidative stress and cancer: Have we moved forward?

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Hsp90 Molecular Chaperone Inhibitors: Are We There Yet?

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Does vitamin C act as a pro‐oxidant under physiological conditions?

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Oxidative Stress and Lipid Peroxidation Products in Cancer Progression and Therapy

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Oncogene Addiction

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Are polyphenols antioxidants or pro-oxidants? What do we learn from cell culture and in vivo studies?

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Chemotherapy-Associated Oxidative Stress: Impact on Chemotherapeutic Effectiveness

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Free radicals and antioxidants – quo vadis?

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Mechanism of action, metabolism, and toxicity of buthionine sulfoximine and its higher homologs, potent inhibitors of glutathione synthesis.

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Nox enzymes, ROS, and chronic disease: An example of antagonistic pleiotropy

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Rapid Restoration of Cognition in Alzheimer's Transgenic Mice with 8-Hydroxy Quinoline Analogs Is Associated with Decreased Interstitial Aβ

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Mechanisms of Neuroprotection by Quercetin: Counteracting Oxidative Stress and More

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Commentary: Vitamin C: Antioxidant or Pro-Oxidant In Vivo?

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Antioxidant Therapy: Current Status and Future Prospects

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Drug development in Alzheimer’s disease: the path to 2025

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Therapeutic strategies for Alzheimer's disease in clinical trials

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Metal dyshomeostasis and oxidative stress in Alzheimer’s disease

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Fenton chemistry in biology and medicine

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Inverse association between cancer and Alzheimer's disease: results from the Framingham Heart Study

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Inhibition of thioredoxin reductase by auranofin induces apoptosis in cisplatin-resistant human ovarian cancer cells

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Glucose metabolism inhibits apoptosis in neurons and cancer cells by redox inactivation of cytochrome c

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Towards a unifying, systems biology understanding of large-scale cellular death and destruction caused by poorly liganded iron: Parkinson’s, Huntington’s, Alzheimer’s, prions, bactericides, chemical toxicology and others as examples

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Oxidative Stress in Alzheimer’s Disease: Why Did Antioxidant Therapy Fail?

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Degradation of the Alzheimer Disease Amyloid β-Peptide by Metal-dependent Up-regulation of Metalloprotease Activity

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The Role of Amyloid Precursor Protein Processing by BACE1, the β-Secretase, in Alzheimer Disease Pathophysiology*

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Novel Tacrine−Melatonin Hybrids as Dual-Acting Drugs for Alzheimer Disease, with Improved Acetylcholinesterase Inhibitory and Antioxidant Properties

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2-Acetylpyridine Thiosemicarbazones are Potent Iron Chelators and Antiproliferative Agents: Redox Activity, Iron Complexation and Characterization of their Antitumor Activity

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Selective Intracellular Release of Copper and Zinc Ions from Bis(thiosemicarbazonato) Complexes Reduces Levels of Alzheimer Disease Amyloid-β Peptide

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Enhancement of auranofin-induced lung cancer cell apoptosis by selenocystine, a natural inhibitor of TrxR1 in vitro and in vivo

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Flavonoids as Therapeutic Compounds Targeting Key Proteins Involved in Alzheimer’s Disease

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Increased Mitochondrial Calcium Sensitivity and Abnormal Expression of Innate Immunity Genes Precede Dopaminergic Defects in Pink1-Deficient Mice

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A Common Biological Mechanism in Cancer and Alzheimers Disease?

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The Alzheimer’s therapeutic PBT2 promotes amyloid‐β degradation and GSK3 phosphorylation via a metal chaperone activity

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Cancer and Neurodegeneration: Between the Devil and the Deep Blue Sea

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Ten misconceptions about antioxidants

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Redox Reactions Induced by Nitrosative Stress Mediate Protein Misfolding and Mitochondrial Dysfunction in Neurodegenerative Diseases

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Advances in using PARP inhibitors to treat cancer

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Alzheimer's disease & metals: therapeutic opportunities

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Site-Activated Multifunctional Chelator with Acetylcholinesterase and Neuroprotective−Neurorestorative Moieties for Alzheimer’s Therapy

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Copper Homeostasis in the CNS: A Novel Link Between the NMDA Receptor and Copper Homeostasis in the Hippocampus

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Biometals and Their Therapeutic Implications in Alzheimer's Disease

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Tacrine–Trolox Hybrids: A Novel Class of Centrally Active, Nonhepatotoxic Multi-Target-Directed Ligands Exerting Anticholinesterase and Antioxidant Activities with Low In Vivo Toxicity

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The 2013 SFRBM Discovery Award: Selected discoveries from the Butterfield laboratory of oxidative stress and its sequela in brain in cognitive disorders exemplified by Alzheimer disease and chemotherapy induced cognitive impairment

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Targeting multiple Alzheimer's disease etiologies with multimodal neuroprotective and neurorestorative iron chelators

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Roles of 3-nitrotyrosine- and 4-hydroxynonenal-modified brain proteins in the progression and pathogenesis of Alzheimer's disease

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Redox signalling in vascular responses to shear and stretch

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Potential Use of the Anti-Inflammatory Drug, Sulfasalazine, for Targeted Therapy of Pancreatic Cancer

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Skin bioavailability of dietary vitamin E, carotenoids, polyphenols, vitamin C, zinc and selenium

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Old and new acetylcholinesterase inhibitors for Alzheimer’s disease

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Iron: A New Target for Pharmacological Intervention in Neurodegenerative Diseases

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Phase 2 study of neoadjuvant treatment with NOV-002 in combination with doxorubicin and cyclophosphamide followed by docetaxel in patients with HER-2 negative clinical stage II–IIIc breast cancer

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Sulfiredoxin–Peroxiredoxin IV axis promotes human lung cancer progression through modulation of specific phosphokinase signaling

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Glucose deprivation-induced metabolic oxidative stress and cancer therapy

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Novel Chelators for Central Nervous System Disorders That Involve Alterations in the Metabolism of Iron and Other Metal Ions

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A novel approach to the identification and quantitative elemental analysis of amyloid deposits—Insights into the pathology of Alzheimer’s disease

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Oxidative lipid modification of nicastrin enhances amyloidogenic γ‐secretase activity in Alzheimer’s disease

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Effect of One-Year Vitamin C- and E-Supplementation on Cerebrospinal Fluid Oxidation Parameters and Clinical Course in Alzheimer’s Disease

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Syntheses of coumarin–tacrine hybrids as dual-site acetylcholinesterase inhibitors and their activity against butylcholinesterase, Aβ aggregation, and β-secretase

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Multifunctional Tacrine Derivatives in Alzheimer’s Disease

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Sulfiredoxin is an AP-1 target gene that is required for transformation and shows elevated expression in human skin malignancies

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Measurement of cholinergic drug effects on memory in alzheimer's disease

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Vitamin Intake and Liver Cancer Risk: A Report From Two Cohort Studies in China

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Modulation of doxorubicin resistance by the glucose-6-phosphate dehydrogenase activity

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Radioiodinated clioquinol as a biomarker for β‐amyloid: Zn2+ complexes in Alzheimer's disease

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Targeting copper(II)-induced oxidative stress and the acetylcholinesterase system in Alzheimer's disease using multifunctional tacrine-coumarin hybrid molecules

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Complex regulation of γ-secretase: from obligatory to modulatory subunits

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Prediction of individual response to anticancer therapy: historical and future perspectives

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A novel method for assessing the role of iron and its functional chelation in fibrin fibril formation: the use of scanning electron microscopy

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Identifying, By First-Principles Simulations, Cu[Amyloid-β] Species Making Fenton-Type Reactions in Alzheimer’s Disease

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Disturbed Copper Bioavailability in Alzheimer′s Disease

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Homocysteine and Alzheimer's disease: a modifiable risk?

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Involvement of reactive oxygen species in 2-methoxyestradiol-induced apoptosis in human neuroblastoma cells

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Dual targeting of the thioredoxin and glutathione antioxidant systems in malignant B cells: A novel synergistic therapeutic approach

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Differences in peripheral oxidative stress markers in A lzheimer's disease, vascular dementia and mixed dementia patients

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7-Methoxytacrine-p-Anisidine Hybrids as Novel Dual Binding Site Acetylcholinesterase Inhibitors for Alzheimer’s Disease Treatment

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Iron Metabolism in Aging and Age-Related Diseases

Tian, Y., Tian, Y., Yuan, Z., Zeng, Y., Wang, S., Fan, X., Yang, D., & Yang, M. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23073612 · Cited by 104 · see citing works

The cellular model for Alzheimer's disease research: PC12 cells

Xie, D., Deng, T., Zhai, Z., Sun, T., & Xu, Y. D. (2023) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2022.1016559 · Cited by 103 · see citing works

Reactive Oxygen Species: A Crosslink between Plant and Human Eukaryotic Cell Systems

Guo, W., Xing, Y., Luo, X., Li, F., Ren, M., & Liang, Y. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms241713052 · Cited by 107 · see citing works

Novel insights in health-promoting properties of sweet cherries

Faienza, M. F., Corbo, F., Carocci, A., Catalano, A. A., Clodoveo, M. L., Grano, M., Wang, D. Q. ‐., D’Amato, G., Muraglia, M., Franchini, C., et al. (2020) · Journal of Functional Foods · doi:10.1016/j.jff.2020.103945 · Cited by 100 · see citing works

A multifunctional Fenton nanoagent for microenvironment-selective anti-biofilm and anti-inflammatory therapy

Li, Y., Xiu, W., Yang, K., Wen, Q., Yuwen, L., Luo, Z., Liu, X., Yang, D., Xie, X., & Wang, L. (2021) · Materials Horizons · doi:10.1039/d0mh01921f · Cited by 97 · see citing works

Protective effect of antioxidant peptides from grass carp scale gelatin on the H2O2-mediated oxidative injured HepG2 cells

Hu, Y., Lu, S.-Z., Li, Y.-S., Wang, H., Shi, Y. G., Zhang, L., & Tu, Z. (2021) · Food Chemistry · doi:10.1016/j.foodchem.2021.131539 · Cited by 98 · see citing works

Berberine: A Promising Treatment for Neurodegenerative Diseases

Cheng, Z., Kang, C., Che, S., Su, J., Sun, Q., Ge, T., Guo, Y. C., Lv, J., Sun, Z., Yang, W., et al. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2022.845591 · Cited by 98 · see citing works

Free radical as a double-edged sword in disease: Deriving strategic opportunities for nanotherapeutics

Zhu, L., Luo, M., Zhang, Y., Fang, F., Li, M., An, F., Zhao, D., & Zhang, J. (2022) · Coordination Chemistry Reviews · doi:10.1016/j.ccr.2022.214875 · Cited by 99 · see citing works

Coumarins as Fungal Metabolites with Potential Medicinal Properties

Tsivileva, O. M., Koftin, O. V., & Evseeva, N. V. (2022) · Antibiotics · doi:10.3390/antibiotics11091156 · Cited by 96 · see citing works

FA-97, a New Synthetic Caffeic Acid Phenethyl Ester Derivative, Protects against Oxidative Stress-Mediated Neuronal Cell Apoptosis and Scopolamine-Induced Cognitive Impairment by Activating Nrf2/HO-1 Signaling

Wan, T., Wang, Z., Luo, Y., Zhang, Y., He, W., Mei, Y., Xue, J., Li, M., Pan, H., Li, W., et al. (2019) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2019/8239642 · Cited by 95 · see citing works

Potential of Microalgal Bioproducts: General Perspectives and Main Challenges

de Souza, M. P., Hoeltz, M., Gressler, P. D., Benitez, L. B., & Schneider, R. D. C. D. S. (2018) · Waste and Biomass Valorization · doi:10.1007/s12649-018-0253-6 · Cited by 93 · see citing works

Trilobatin Protects Against Oxidative Injury in Neuronal PC12 Cells Through Regulating Mitochondrial ROS Homeostasis Mediated by AMPK/Nrf2/Sirt3 Signaling Pathway

Gao, J., Liu, S., Xu, F., Liu, Y., Lv, C., Deng, Y., Shi, J., & Gong, Q. (2018) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2018.00267 · Cited by 92 · see citing works

Nanozyme‐Based Regulation of Cellular Metabolism and Their Applications

Wang, Y., Jia, X., An, S., Yin, W., Huang, J., & Jiang, X. (2023) · Advanced Materials · doi:10.1002/adma.202301810 · Cited by 94 · see citing works

Mechanisms for Tuning Engineered Nanomaterials to Enhance Radiation Therapy of Cancer

Clement, S., Campbell, J. M., Deng, W., Guller, A., Nisar, S., Liu, G., Wilson, B. C., & Goldys, E. M. (2020) · Advanced Science · doi:10.1002/advs.202003584 · Cited by 88 · see citing works

In-vitro evaluation of apoptotic effect of OEO and thymol in 2D and 3D cell cultures and the study of their interaction mode with DNA

Jamali, T., Kavoosi, G., Safavi, M., & Ardestani, S. K. (2018) · Scientific Reports · doi:10.1038/s41598-018-34055-w · Cited by 92 · see citing works

Bright and sensitive ratiometric fluorescent probe enabling endogenous FA imaging and mechanistic exploration of indirect oxidative damage due to FA in various living systems

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A Review of Bioactive Compounds and Antioxidant Activity Properties of Piper Species

Carsono, N., Tumilaar, S. G., Kurnia, D., Latipudin, D., & Satari, M. H. (2022) · Molecules · doi:10.3390/molecules27196774 · Cited by 90 · see citing works

Dietary Polyphenols: A Multifactorial Strategy to Target Alzheimer’s Disease

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Oxidative Stress in Cancer Therapy: Friend or Enemy?

Azmanova, M., & Pitto‐Barry, A. (2022) · ChemBioChem · doi:10.1002/cbic.202100641 · Cited by 119 · see citing works

Novel therapeutic approaches targeting oxidative stress in breast and lung cancer

Kaushik, P., Kaushik, M., & Parvez, S. (2022) · Elsevier eBooks · doi:10.1016/b978-0-323-90905-1.00010-9 · Cited by 4 · see citing works

Oxidative stress and cancer: current insights and therapeutic implications

Escribano-Cebrián, M., Bataller, M., Biasini, M., Garcia‐Mayea, Y., Porcuna, D. V., & LLeonart, M. E. (2026) · Redox Biology · doi:10.1016/j.redox.2026.104355 · Cited by 1 · see citing works

Oxidative stress: A target to treat Alzheimer's disease and stroke

Briyal, S., Ranjan, A. K., & Gulati, A. (2023) · Neurochemistry International · doi:10.1016/j.neuint.2023.105509 · Cited by 86 · see citing works

Selective Induction of Oxidative Stress in Cancer Cells via Novel Therapeutic Approaches

Akladios, F. N. (2016) · Charles Sturt University Research Output (CRO)