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Cited by 21Poisoning and overdose treatmentsForensic Toxicology and Drug AnalysisPharmacology and Obesity Treatment

2,4-Dinitrophenol: A threat to Chinese body-conscious groups

Lee, Han Chih Hencher, Law, Chun Yiu, Chen, Mo Lung, Lam, Ying Hoo, Chan, Albert Yan Wo, Mak, Tony Wing Lai·2014·Journal of the Chinese Medical Association
DOI 10.1016/j.jcma.2014.05.003
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Abstract

2,4-Dinitrophenol (2,4-DNP), a yellowish compound, has historically been used in the manufacture of dyes, explosives, and fungicides. As it uncouples mitochondrial oxidative phosphorylation, the compound was also used as an antiobesity agent early in the past century. The compound was subsequently banned by the United States Food and Drug Administration in 1938 due to its potentially fatal adverse effects, including hyperthermia, cataract, agranulocytosis, hepatoxicity, nephrotoxicity, and cardiotoxicity. However, the popularity of 2,4-DNP as a slimming aid has appeared to increase again in recent years. The Hong Kong Hospital Authority Toxicology Reference Laboratory recently confirmed two cases of self-administered 2,4-DNP with different clinical presentations to hospitals in the area. Here we describe those two cases, in an attempt to underscore the potential of misuse of this substance by body-conscious groups among the Chinese population.

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  • More recently, an increase in the use of DNP as self-medication has been observed in China and the United Kingdom, leading to new cases of DNP-associated fatalities.

    “More recently, an increase in the use of DNP as a self-medication has been observed in China [266] and the United Kingdom [267], leading to new cases of DNP-associated fatalities.”

    From Mitochondrial Uncoupling: A Key Controller of Biological Processes in Physiology and Diseases (2019) · cites this paper as [266]

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Authors
Lee, H. C. H., Law, C. Y., Chen, M. L., Lam, Y. H., Chan, A. Y. W., & Mak, T. W. L.
Affiliations
Hospital Authority (HK)
ORCID
Venue
Journal of the Chinese Medical Association
Publisher
Ovid Technologies (Wolters Kluwer Health)
Published
2014-08
Volume
77
Issue
8
Pages
443-445
ISSN
1726-4901 (ISSN-L)
DOI
10.1016/j.jcma.2014.05.003
OpenAlex
W1988791330
Cited by
21
References
15
Citations by year
2026: 1 · 2025: 2 · 2023: 1 · 2022: 1 · 2020: 5 · 2019: 2 · 2018: 1 · 2017: 2 · 2016: 3 · 2015: 3
FWCI
2.84
Type
journal article
Language
en
Open access
closed
Licence
Locations
  • Journal of the Chinese Medical Association (publishedVersion)
  • PubMed (publishedVersion)
  • The HKU Scholars Hub (University of Hong Kong) (submittedVersion)
Topics
  • Health Sciences › Medicine › Emergency Medicine › Poisoning and overdose treatments
  • Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Toxicology › Forensic Toxicology and Drug Analysis
  • Health Sciences › Medicine › Pharmacology › Pharmacology and Obesity Treatment
Keywords
2,4-dinitrophenol, uncoupling agents, mitochondrial oxidative phosphorylation, anti-obesity drugs, self-administration, adverse effects, hyperthermia, toxicology, Chinese population
MeSH terms
Adult, Female, Hong Kong, Humans, Male, 2,4-Dinitrophenol, Anti-Obesity Agents

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