Cited by 280Cardiac Imaging and DiagnosticsCoronary Interventions and DiagnosticsCardiac Health and Mental Health

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Prognostic Value of Coronary Computed Tomographic Angiography for Prediction of Cardiac Events in Patients With Suspected Coronary Artery Disease

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Hadamitzky, Martin, Freißmuth, Barbara, Meyer, Tanja, Hein, Franziska, Kastrati, Adnan, Martinoff, Stefan, Schömig, Albert, Hausleiter, Jörg·2009·JACC: Cardiovascular Imaging

DOI 10.1016/j.jcmg.2008.11.015

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Abstract

Objectives We assessed the rate of cardiac events after detection or exclusion of obstructive coronary artery disease (CAD) by coronary computed tomography angiography (CCTA).Background Several studies have demonstrated a high diagnostic accuracy of CCTA for detection of obstructive CAD compared with invasive angiography, but data regarding the clinical prognostic value of CCTA are limited.Methods In all, 1,256 consecutive patients with suspected CAD undergoing 64-slice CCTA in our institution between October 2004 and September 2006 were observed prospectively for the occurrence of severe cardiac events (cardiac death, myocardial infarction, or unstable angina requiring hospitalization: primary study end point) and all cardiac events (additionally including revascularization >90 days after CCTA). The observed rate of all cardiac events was compared with the event rate predicted by the Framingham risk score. Obstructive CAD was defined as > or = 50% diameter stenosis in any coronary artery.Results During a median follow-up of 18 months (interquartile range 14 to 25 months), the overall rates of severe and all cardiac events were 0.6% and 1.8%, respectively. In 802 patients without obstructive CAD, there were 4 cardiac events, of which 1 was severe, whereas in 348 patients with obstructive CAD, there were 17 cardiac events, of which 5 were severe. The difference between the 2 groups was highly significant both for severe events (odds ratio: 17.3, 95% confidence interval: 3.6 to 82.5) and for all cardiac events (odds ratio: 16.1, 95% confidence interval: 7.2 to 36.0; both p < 0.001). The rate of all cardiac events in patients without obstructive CAD was significantly lower than predicted by the Framingham risk score (p = 0.01).Conclusions In patients with suspected CAD, CCTA has a significant prognostic impact on the prediction of cardiac events for the subsequent 18 months. The exclusion of obstructive CAD by CCTA identifies a patient population with an event risk lower than predicted by conventional risk factors.

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Self-citation
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BackgroundMethodInfluential
Association of Neutrophil/Lymphocyte Ratio with Plaque Morphology in Patients with Asymptomatic Intermediate Carotid Artery Stenosis
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Result
The Year in Coronary Artery Disease
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“From previous studies performed in patients with suspected coronary artery disease, the prognostic value of CT angiography had been evaluated, which showed that degree of stenosis and number of involved segments detected by CT angiography had significant incremental predictive value compared to calcium scoring and oth…”
Background
Coronary plaque characteristics on baseline CT predict the need for late revascularization in symptomatic patients after percutaneous intervention
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“The criteria defining each HRP characteristic were based on classifications from previous studies [17].”
Method
Subclinical Atherosclerosis Imaging in People Living with HIV
Schoepf, I. C., Buechel, R. R., Kovari, H., Hammoud, D. A., & TARR, P. E. (2019) · Journal of Clinical Medicine · doi:10.3390/jcm8081125 · Cited by 13
“CCTA improves prediction of future CV events compared to Framingham risk score [120], CAC [107,108,121] or CIMT [108,118].”
Method
Subclinical coronary atherosclerosis identified by coronary computed tomographic angiography in asymptomatic morbidly obese patients
Lubanski, M., Vanhecke, T. E., Chinnaiyan, K. M., Franklin, B. A., & McCullough, P. A. (2010) · Heart International · doi:10.4081/hi.2010.e15 · Cited by 13
“Hadamitzky et al.(24) reported that the event rate was significantly lower in patients with nonobstructive disease and higher in obstructive disease compared to the predicted Framingham risk scores.”
ResultInfluential
Automatic detection and quantification of coronary calcium on 3D CT angiography data
Teßmann, M., Vega-Higuera, F., Bischoff, B., Hausleiter, J., & Greiner, G. (2010) · Computer Science - Research and Development · doi:10.1007/s00450-010-0131-3 · Cited by 13
“Hence, more and more clinical studies are carried out and are published with the goal of establishing an equivalence between traditional coronary calcium (CAC) scoring and calcium scoring on CTCA data in order to provide additional information for coronary risk stratification and avoiding redundant CT scanning [6, 9].”
BackgroundSelf-citation
Long-Term Prognostic Value of Coronary CTA in Orthotopic Heart Transplant Recipients
García-Baizán, A., Caballeros, M., Ezponda, A., Manrique, R., Gavira, J. J., Rábago, G., & Bastarrika, G. (2021) · American Journal of Roentgenology · doi:10.2214/ajr.20.23535 · Cited by 12
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Uretsky, S., Rozanski, A., Supariwala, A. A., Thotakura, G., Kanneganti, S., Satyanarayana, N., Mantrala, P., Yeturi, S., Peters, M. R., Fisher, E. A. A., et al. (2011) · International Journal of Cardiology · doi:10.1016/j.ijcard.2011.08.852 · Cited by 12
“Third, our follow-up period of ~3 years is relatively short given the low risk of our patient population, but is comparable or greater in length compared to the follow-up periods within prior CCTA studies which did observe a correlation between the magnitude of atherosclerosis and subsequent adverse events [15–19].”
Result
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Luchian, M., Lochy, S., Motoc, A. I., Belsack, D., Magné, J., Roosens, B., Mey, J. D., Tanaka, K., Scheirlynck, E., Boeckstaens, S., et al. (2021) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2021.684528 · Cited by 13
“Moreover, CAC score has been shown to improve cardiovascular risk prediction in addition to classical risk factors (5, 6, 20) and to be a potential tool for risk reclassification (21–24).”
Background
Assessment of coronary stenosis, plaque burden and remodeling by multidetector computed tomography in patients referred for suspected coronary artery disease
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Frontline diagnostic evaluation of patients suspected of angina by coronary computed tomography reduces downstream resource utilization when compared to conventional ischemia testing
Nielsen, L. H., Markenvard, J., Jensen, J. M., Mickley, H., Øvrehus, K. A., & Nørgaard, B. L. (2010) · International journal of cardiac imaging · doi:10.1007/s10554-010-9737-6 · Cited by 11
“tive CTA test result seems to be highly favorable [26].”
Background
Thyrotropin and free thyroxine levels and coronary artery disease: cross-sectional analysis of the Brazilian Longitudinal Study of Adult Health (ELSA-Brasil)
de Miranda, É. J. F. P., Bittencourt, M. S., Staniak, H. L., Sharovsky, R., Pereira, A. C., Foppa, M., Santos, I. S., Lotufo, P. A., & Benseñor, I. M. (2018) · Brazilian Journal of Medical and Biological Research · doi:10.1590/1414-431x20177196 · Cited by 11
Plasma vaspin is an effective biomarker for evaluation of future cardiovascular events in patients with chest pain: a 5-year retrospective observational study
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“Deaths caused by accidents were excluded (follow-up censored at the time of death) (14,17).”
Background
Epicardial adipose tissue characteristics and CT high-risk plaque features: correlation with coronary thin-cap fibroatheroma determined by intravascular ultrasound
Yuan, M., Wu, H., Li, R., Yu, L., & Zhang, J. (2020) · International journal of cardiac imaging · doi:10.1007/s10554-020-01917-2 · Cited by 11
A comparison of Diamond Forrester and coronary calcium scores as gatekeepers for investigations of stable chest pain
McKavanagh, P., Lusk, L., Ball, P. A., TRINICK, T. R., Duly, E. B., Walls, G., Orr, C., Harbinson, M., & Donnelly, P. M. (2013) · International journal of cardiac imaging · doi:10.1007/s10554-013-0226-6 · Cited by 11
Influence of Cardiovascular Risk Factors on the Prevalence of Coronary Atherosclerosis in Patients with Angiographically Normal Coronary Arteries
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Relative diagnostic, prognostic and economic value of stress echocardiography versus exercise electrocardiography as initial investigation for the detection of coronary artery disease in patients with new onset suspected angina
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“The cut-off value of 50% was used as it has been previously shown to convey prognostic significance [10].”
Method
Performance of traditional risk factors in identifying a higher than expected coronary atherosclerotic burden
Dores, H., Gonçalves, P. D. A., Ferreira, A. M., Carvalho, M. S., Sousa, P. J., Cardim, N. M., Marques, H., & Machado, F. P. (2015) · Revista Portuguesa de Cardiologia · doi:10.1016/j.repc.2014.08.030 · Cited by 10
“The extent of coronary calcification correlates with total coronary plaque burden, and has a high negative predictive value for ruling out the presence of significant coronary stenosis.5,6 Additionally, the calcium score (CS) also has a prognostic impact, as it can show increased risk of MI.7,8 In previous studies, th…”
Background
Anatomy Meets Function
Achenbach, S. S. (2011) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2011.09.006 · Cited by 10
Incremental prognostic value of downstream positron emission tomography perfusion imaging after coronary computed tomography angiography: a study using machine learning
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Interobserver agreement for the detection of atherosclerotic plaque in coronary CT angiography: comparison of two low-dose image acquisition protocols with standard retrospectively ECG-gated reconstruction
Schuhbäck, A., Marwan, M., Gauss, S., Muschiol, G., Ropers, D., Schneider, C., Lell, M., Rixe, J., Hamm, C. W., Daniel, W. G., et al. (2012) · European Radiology · doi:10.1007/s00330-012-2389-2 · Cited by 10
“predictive value of non-stenotic plaque concerning future cardiovascular events [2–8].”
Recent developments in cardiac CT
van der Bijl, N., Geleijns, J., Joemai, R. M. S., Bax, J. J., Schuijf, J. D., Roos, A., & Kroft, L. J. M. (2011) · Imaging in Medicine · doi:10.2217/iim.11.7 · Cited by 10
Coronary Atherosclerosis Assessment by Coronary CT Angiography in Asymptomatic Diabetic Population: A Critical Systematic Review of the Literature and Future Perspectives
Guaricci, A. I., Santis, D. D., Carbone, M., Muscogiuri, G., Guglielmo, M., Baggiano, A., Serviddio, G., & Pontone, G. (2018) · BioMed Research International · doi:10.1155/2018/8927281 · Cited by 10
Using Coronary Artery Calcium Scoring as Preventative Health Tool to Reduce the High Burden of Cardiovascular Disease in Indigenous Australians
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Long-term prognostic value of whole-heart coronary magnetic resonance angiography
Nakamura, S., Ishida, M., Nakata, K., Ichikawa, Y., Takase, S., Takafuji, M., Ito, H., Nakamori, S., Kurita, T., Dohi, K., et al. (2021) · Journal of Cardiovascular Magnetic Resonance · doi:10.1186/s12968-021-00749-w · Cited by 10
Prognostic Implications of Nonobstructive Coronary Artery Disease in Patients Undergoing Coronary Computed Tomographic Angiography for Acute Chest Pain
Beigel, R., Brosh, S., Goitein, O., Guttman, E., Novikov, I., Segev, A., Gerber, Y., Oieru, D., Konen, E., Hod, H., et al. (2013) · The American Journal of Cardiology · doi:10.1016/j.amjcard.2012.12.010 · Cited by 10
β-Blocker premedication does not increase the frequency of allergic reactions from coronary CT angiography: Results from the Advanced Cardiovascular Imaging Consortium
Aggarwal, A., Smith, J. L., Chinnaiyan, K. M., Mehta, N. S., Boura, J., Abdulla, R. K., Lauter, C. B., & Raff, G. L. (2015) · Journal of cardiovascular computed tomography · doi:10.1016/j.jcct.2015.02.003 · Cited by 9
Appropriate indications for computed tomography coronary angiography
Liew, G. Y. H., Feneley, M. P., & Worthley, S. G. (2012) · The Medical Journal of Australia · doi:10.5694/mja11.10130 · Cited by 9
A TEN YEAR OVERVIEW OF SURGICAL AND INTERVENTIONAL ARRHYTHMOLOGY IN RUSSIA. SERVICE PECULIAR FEATURES IN THE FAR EAST
Богачевская, С. А., & Николаевич, Б. А. (2017) · Social Aspects of Population Health · doi:10.21045/2071-5021-2017-53-1-1 · Cited by 10
Association between coronary artery atherosclerosis and plasma glucose levels assessed by dual-source computed tomography
Yu, Y., Zhou, Z., Sun, K., Xi, L., Zhang, L., Yu, L., Wang, J., Zheng, J., & Ding, M. L. (2018) · Journal of Thoracic Disease · doi:10.21037/jtd.2018.10.62 · Cited by 9
The Year in Coronary Artery Disease
Achenbach, S. S., Kramer, C. M., Zoghbi, W. A., & Dilsizian, V. (2010) · JACC. Cardiovascular imaging · doi:10.1016/j.jcmg.2010.08.010 · Cited by 9
Angiografía mediante tomografía computarizada cardiaca: una técnica versátil
Alexánderson, E., González, A. M., & Jiménez‐Santos, M. (2011) · Revista Española de Cardiología · doi:10.1016/j.recesp.2010.11.007 · Cited by 9
“The second method, a scan performed with the injection of iodinated contrast media, uses more refined imaging protocols (CCTA) and is capable of detecting non-calcified plaque components and characterizing such plaque.(1,8-10) The main clinical application of this technology relies on CAD evaluation.”
Method
Prognostic value of cardiovascular CT: Is coronary artery calcium screening enough? The added value of CCTA
Alexánderson, E., Canseco-León, N., Iñarra-Talboy, F., Meave, A., & Dey, D. (2012) · Journal of Nuclear Cardiology · doi:10.1007/s12350-012-9549-2 · Cited by 8
Association of hepatic steatosis with epicardial fat volume and coronary artery disease in symptomatic patients
Ledda, R. E., Milanese, G., Cademartiri, F., Maffei, E., Benedetti, G., Goldoni, M., Silva, M., & Sverzellati, N. (2021) · La radiologia medica · doi:10.1007/s11547-020-01321-9 · Cited by 8
“1 3 at least 1 segment had a lumen narrowing ≥ 50% [23].”
Background
Machine Learning to Predict Long-Term Cardiac-Relative Prognosis in Patients With Extra-Cardiac Vascular Disease
Lin, G., Liu, Q., Chen, Y., Zong, X., Xi, Y., Li, T., Yang, Y., Zeng, A., Chen, M., Liu, C., et al. (2021) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2021.771504 · Cited by 8
“Coronary CTA has great value for CAD risk stratification (30, 31) but traditional methods usually analyze a single metric at a time, for instance, luminal stenosis severity, plaque burden, or coronary calcium content alone, leaving other important variables unexplored (32).”
Background
Coronary CT angiography in acute chest pain
Goyal, N., & Stillman, A. E. (2017) · F1000Research · doi:10.12688/f1000research.11250.1 · Cited by 8
“5,10,11 .”
Geographic and Individual Correlates of Subclinical Atherosclerosis in an Asymptomatic Rural Appalachian Population
Mamudu, H. M., Jones, A., Paul, T. K., Subedi, P., Wang, L., Alamian, A., Alamin, A. E., Blackwell, G. G., & Budoff, M. J. (2017) · The American Journal of the Medical Sciences · doi:10.1016/j.amjms.2017.08.011 · Cited by 8
Coronary CT Angiography and Comparative Effectiveness Research
Schoenhagen, P., Hachamovitch, R., & Achenbach, S. S. (2011) · JACC. Cardiovascular imaging · doi:10.1016/j.jcmg.2011.02.013 · Cited by 8
Prognostic value of Morise clinical score, calcium score and computed tomography coronary angiography in patients with suspected or known coronary artery disease
Maffei, E., Seitun, S., Palumbo, A., Martini, C., Emiliano, E. G., Cuttone, A., Aldrovandi, A., Malagò, R., Grutta, L. L., Midiri, M., et al. (2011) · La radiologia medica · doi:10.1007/s11547-011-0721-6 · Cited by 8
Comparison between low-dose multidetector computed coronary angiography and myocardial perfusion imaging test in patients with intermediate pre-test likelihood of coronary artery disease
Pontone, G., Andreini, D., Bartorelli, A. L., Bertella, E., Mushtaq, S., Cortinovis, S., Chiappa, L., Annoni, A. D., Formenti, A., Trabattoni, D., et al. (2011) · International Journal of Cardiology · doi:10.1016/j.ijcard.2010.12.107 · Cited by 7
Influence of coronary computed tomography-angiography on patient management
Jukić, M., Pavić, L., Habek, J. Č., Medaković, P., Delić-Brkljačić, D., & Brkljačić, B. (2012) · Croatian Medical Journal · doi:10.3325/cmj.2012.53.4 · Cited by 7
Echocardiographic calcification score in patients with low/intermediate cardiovascular risk
Hirschberg, K., Reinhart, M., Mereles, D., Uhlmann, L., André, F., Riffel, J. H., Ochs, M. M., & Katus, H. A. (2018) · Clinical Research in Cardiology · doi:10.1007/s00392-018-1343-y · Cited by 7
Coronary CT angiography alone versus with CT perfusion: a systematic review and meta-analysis assessing approaches for chest pain
D’Ascenzo, F., Faletti, R., Pietro, G. D., Improta, R., Bruno, F., Schoepf, U. J., Vita, U. D., Giacobbe, F., Nebiolo, M., Siliano, S., et al. (2025) · European Radiology · doi:10.1007/s00330-025-11459-7 · Cited by 6
Prognostic utility of coronary computed tomographic angiography
Otaki, Y., Berman, D. S., & Min, J. K. (2013) · Indian Heart Journal · doi:10.1016/j.ihj.2013.04.028 · Cited by 6
“Of these, one of the larger scale studies with relatively longer follow-up was performed by Hadamitzky et al.22 At 18 months of follow-up, they prospectively identified among 1256 patients with suspected CAD the occurrence of MACE, inclusive of cardiac death, myocardial infarction (MI), or unstable angina requiring ho…”
Background
Innovation in Three-Dimensional Echocardiography and Cardiac Computed Tomographic Angiography
Hlavacek, A. M., Baker, G. H., & Shirali, G. S. (2009) · Cardiology in the Young · doi:10.1017/s1047951109991600 · Cited by 6
“In adult patients, it has been shown to be an accurate and predictive imaging modality for the detection of coronary arterial disease.(29,30) As the technology advances, its accuracy in detecting coronary arterial lesions has continued to increase.”
Method
Tomografia de coronárias na predição de eventos adversos em pacientes com suspeita de coronariopatia
Barros, M. V. L., Rabelo, D. R., Nunes, M. C. P., & Siqueira, M. H. A. (2012) · Arquivos Brasileiros de Cardiologia · doi:10.1590/s0066-782x2012005000113 · Cited by 6
“Diabete melito 25 (9) 14 (25) 2,86 (1,55 –5,27) 0,001”
Computational clustering reveals differentiated coronary artery calcium progression at prevalent levels of pulse wave velocity by classifying high-risk patients
Portalis, M. R., Cymberknop, L. J., Farro, I., & Armentano, R. L. (2023) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2023.1161914 · Cited by 6
“This method is a strong predictor of cardiovascular events (19) and is considered by ACC/AHA and the European Society of Cardiology for risk reclassification among patients with low to intermediate risk, i.”
Method
Noninvasive Anatomical Coronary Artery Imaging Versus Myocardial Perfusion Imaging
Hacıoğlu, Y., Gupta, M. D., & Budoff, M. J. (2010) · Journal of Computer Assisted Tomography · doi:10.1097/rct.0b013e3181e10525 · Cited by 6
Coronary Atherosclerosis Imaging by Coronary CT Angiography
Villines, T. C., Rinehart, S. J., Qian, Z., & Vörös, S. (2012) · Springer eBooks · doi:10.1007/978-1-4471-4288-1_9 · Cited by 6
Effect of smoking status on coronary artery disease among Chinese post-menopausal women
Ma, J., Wang, X., Gao, M. C., Ding, Y., & Guan, Y. (2015) · Internal and Emergency Medicine · doi:10.1007/s11739-015-1334-1 · Cited by 6
“[15] Furthermore, an approximately fivefold event rate (non-fatal myocardial infarction and unstable angina) among current smokers compared with never smokers is observed.”
Background
Major adverse cardiac event rates in moderate‐risk patients: Does prior coronary disease matter?
McGinnis, H. D., Ashburn, N. P., Paradee, B. E., O’Neill, J. C., Snavely, A. C., Stopyra, J. P., & Mahler, S. A. (2022) · Academic Emergency Medicine · doi:10.1111/acem.14462 · Cited by 6
Rationale, design and methods of CTCA-PRORECAD (Computed Tomography Coronary Angiography Prognostic Registry for Coronary Artery Disease): a multicentre and multivendor registry
Maffei, E., Midiri, M., Russo, V. C., Rengo, M., Tedeschi, C., Spagnolo, P., Seitun, S., Francone, M., Guaricci, A. I., Carrabba, N., et al. (2013) · La radiologia medica · doi:10.1007/s11547-012-0912-9 · Cited by 6
Current Clinical Applications of Cardiac Computed Tomography
Achenbach, S. S. (2011) · Journal of Cardiovascular Translational Research · doi:10.1007/s12265-011-9278-y · Cited by 6
Predictive Values of Framingham Risk and Coronary Artery Calcium Scores in the Detection of Obstructive CAD in Patients with Normal SPECT
Jang, J. J., Krishnaswami, A., & Hung, Y. (2011) · Angiology · doi:10.1177/0003319711415392 · Cited by 6
“Interestingly, the study found that results from CCTA were more predictive of cardiac event rates than the Framingham risk calculation.(5) In addition to Framingham risk, elevated CACS (>100 AU) were significantly associated with obstructive CAD on CTA (Table 1 and 3).”
Result
Coronary CT Angiography in Coronary Artery Disease: from Diagnosis to Prevention
Sun, Z., & Lin, C. (2014) · Heart Research - Open Journal · doi:10.17140/hroj-1-101 · Cited by 5
Bridging the Detection Gap Chasm of Risk: Where Can Computed Tomography Angiography Take Us?
Shaw, L., & Narula, J. (2009) · JACC. Cardiovascular imaging · doi:10.1016/j.jcmg.2009.02.003 · Cited by 6
Computed Tomography Evaluation of Coronary Atherosclerosis: The Road Travelled, and What Lies Ahead
Ayoub, C., Scalia, I. G., Anavekar, N. S., Arsanjani, R., Jokerst, C. E., Chow, B. J. W., & Kritharides, L. (2024) · Diagnostics · doi:10.3390/diagnostics14182096 · Cited by 5
Stress Perfusion Cardiac Magnetic Resonance in Long-Standing Non-Infarcted Chronic Coronary Syndrome with Preserved Systolic Function
Palumbo, P., Cannizzaro, E., Cesare, A. D., Bruno, F., Arrigoni, F., Splendiani, A., Barile, A., Masciocchi, C., & Cesare, E. D. (2022) · Diagnostics · doi:10.3390/diagnostics12040786 · Cited by 5
Visualizing Vulnerability
Shapiro, E. P., & Bush, D. E. (2013) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2013.01.088 · Cited by 5
Effectiveness of Using Dual-source CT and the Upshot it creates on Both Heart Rate and Image Quality
Selçuk, T., Temur, H. O., Yüceler, Z., Bilgili, Ç. Ö., Bulakçı, M., Savaş, Y., & Çelik, Ö. (2016) · Balkan Medical Journal · doi:10.5152/balkanmedj.2016.16220 · Cited by 5
The Role of Inflammatory Biomarkers in the Assessment of Coronary Artery Disease
Napoleão, P., Selas, M., Freixo, C., Ramos, C., Andreozzi, V., Turkman, M. A. A., Mota, M., María, A., Cruz, R., & Pinheiro, T. (2011) · InTech eBooks · doi:10.5772/18117 · Cited by 5
“…neither the absence of high-grade stenosis provided by imaging modalities such as angiography assure the lack of future cardiac events, nor the cardiovascular events are readily explained by cardiovascular risk factors (Fisher et al., 2000; Kern, 2000; Hadamitzky et al., 2009; Marwan et al., 2009).”
Background
Computed tomography coronary angiography in the selection of outlier patients: a feasibility report
Maffei, E., Martini, C., Seitun, S., Arcadi, T., Tedeschi, C., Guaricci, A. I., Malagò, R., Tarantini, G., Aldrovandi, A., & Cademartiri, F. (2011) · La radiologia medica · doi:10.1007/s11547-011-0695-4 · Cited by 5
Prognostic value of coronary CT angiography: lessons from the West Denmark Cardiac Registry
Leipsic, J. A., & Blanke, P. (2016) · European Heart Journal · doi:10.1093/eurheartj/ehw634 · Cited by 5
Mixed plaque on coronary CT angiography predicts atherosclerotic events in asymptomatic intermediate-risk individuals
Warren, J., Ellims, A., Bloom, J. E., Sutherland, N., Lew, P., Kavnoudias, H., Paleri, S., Stub, D. A., & Taylor, A. J. (2024) · Open Heart · doi:10.1136/openhrt-2024-002609 · Cited by 4
“Future randomised, prospective trials are required to determine whether initiation of treatment based on the presence of mixed plaque on CCTA significantly impacts outcomes. assist in predicting cardiac events, 5–9 it is not currently integrated into the guidelines as a risk-modifying tool.”
Background
Can Coronary Computed Tomography Angiography Replace Invasive Angiography?
Achenbach, S. S. (2015) · Circulation · doi:10.1161/circulationaha.114.008146 · Cited by 4
Prognostic value of coronary computed tomographic angiography in patients with arterial hypertension
Hadamitzky, M., Meyer, T. S., Hein, F., Bischoff, B., Byrne, R. A., Martinoff, S. A., Schömig, A., & Hausleiter, J. (2011) · International journal of cardiac imaging · doi:10.1007/s10554-011-9851-0 · Cited by 4
Self-citation
Stress Computed Tomography Myocardial Perfusion
Achenbach, S. S. (2009) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2009.05.048 · Cited by 4
Understanding the predictive value and methods of risk assessment based on coronary computed tomographic angiography in populations with coronary artery disease: a review
Li, Y., Jia, K., Jia, Y., Yang, Y., Yao, Y., Chen, M., & Peng, Y. (2021) · Precision Clinical Medicine · doi:10.1093/pcmedi/pbab018 · Cited by 4
What is the Value of CT Angiography for Patients with Acute Chest Pain?
Medina, H. M., Rojas, C. A., & Hoffmann, U. (2010) · Current Treatment Options in Cardiovascular Medicine · doi:10.1007/s11936-009-0058-9 · Cited by 4
“The excellent NPV of major adverse events in patients with normal CCTA has been corroborated by other investigators in several cohorts, and there is evidence that it may be a better predictor of future events than traditional risk factors [ 35 ].”
Result
Differential Prognostic Value of Coronary Computed Tomography Angiography in Relation to Exercise Electrocardiography in Asymptomatic Subjects
Lee, S., Cho, I., Hong, G., Chang, H., Sung, J. M., Cho, I., Shim, C. Y., Choi, B. W., & Chung, N. (2015) · Journal of Cardiovascular Ultrasound · doi:10.4250/jcu.2015.23.4.244 · Cited by 4
From stenosis imaging to functional imaging: a new horizon of coronary computed tomography
Choi, J., Choe, Y. H., & Min, J. K. (2010) · International journal of cardiac imaging · doi:10.1007/s10554-010-9751-8 · Cited by 4
“Moreover, not only the severity of stenosis but also the extent of plaque burden evaluated by CCTA has been shown to identify future risk of cardiovascular events or allcause death [4].”
Background
Determining patient prognosis using computed tomography coronary angiography
Kazmi, M. H., Small, G. R., Sleiman, L., & Chow, B. J. W. (2011) · Expert Review of Medical Devices · doi:10.1586/erd.11.31 · Cited by 3
Die Rolle der Kardio-CT im klinischen Alltag – Update 2010
Achenbach, S. S. (2010) · DMW - Deutsche Medizinische Wochenschrift · doi:10.1055/s-0030-1263339 · Cited by 3
2021. évi ESC-irányelvek a szív- és érrendszeri betegségek megelőzéséről a klinikai gyakorlatban
Szabados, E., Sándor, B., & Pálfi, A. (2022) · Cardiologia Hungarica · doi:10.26430/chungarica.2022.52.5.60 · Cited by 3
“Kontrasztos koronária CT-angiográfia (CCTA) A CCTA detektálja a koszorúér-szűkületet és előre jelzi a kardiális eseményeket (31), azonban arra vonatkozóan nincs adat, hogy javítja-e a betegek kockázati besorolását.”
Coming of Age
Bastarrika, G., & Schoepf, U. J. (2010) · Journal of Thoracic Imaging · doi:10.1097/rti.0b013e3181cf8170 · Cited by 3

Authors: Hadamitzky, M., Freißmuth, B., Meyer, T., Hein, F., Kastrati, A., Martinoff, S., Schömig, A., & Hausleiter, J.
Affiliations: Deutsches Herzzentrum München (DE)
Corresponding author: Hadamitzky, Martin
ORCID: Hadamitzky, Martin
Kastrati, Adnan
Hausleiter, Jörg
Venue: JACC: Cardiovascular Imaging
Publisher: Elsevier BV
Published: 2009-04
Volume: 2
Issue: 4
Pages: 404-411
ISSN: 1876-7591 (ISSN-L)
1936-878X
DOI: 10.1016/j.jcmg.2008.11.015
OpenAlex: W2022807949
Cited by: 280
References: 21
Citations by year: 2026: 5 · 2025: 5 · 2024: 7 · 2023: 7 · 2022: 11 · 2021: 18 · 2020: 9 · 2019: 9 · 2018: 7 · 2017: 12 · 2016: 21 · 2015: 19 · 2014: 18 · 2013: 24 · 2012: 27
FWCI: 26.95
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
www.elsevier.com/open-access/userlicense/1.0/ (vor, 1604 d)
Locations: JACC. Cardiovascular imaging (publishedVersion)
PubMed (publishedVersion)
mediaTUM – the media and publications repository of the Technical University Munich (Technical University Munich) (submittedVersion)
Topics: Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Cardiac Imaging and Diagnostics
Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Coronary Interventions and Diagnostics
Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac Health and Mental Health
Keywords: coronary CT angiography, obstructive coronary artery disease, prognostic value, cardiac events, myocardial infarction, unstable angina, cardiovascular mortality, revascularization, Framingham risk score, risk prediction, 64-slice CT
MeSH terms: Aged, Female, Heart Diseases, Hospitalization, Humans, Male, Middle Aged, Myocardial Revascularization, Predictive Value of Tests, Prospective Studies, Risk Factors, Time Factors, Tomography, X-Ray Computed, Odds Ratio, Treatment Outcome, Coronary Angiography, Risk Assessment, Coronary Stenosis, Kaplan-Meier Estimate

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Prognostic Value of Coronary Computed Tomographic Angiography for Prediction of Cardiac Events in Patients With Suspected Coronary Artery Disease

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