The DOI matches its Crossref record; 23 of the 23 references it cites were found in a registry or an index.
Prognostic Value of Right Ventricular Longitudinal Strain in Patients With COVID-19
Open accessAbstract
Objectives The aim of this study was to investigate whether right ventricular longitudinal strain (RVLS) was independently predictive of higher mortality in patients with coronavirus disease-2019 (COVID-19). Background RVLS obtained from 2-dimensional speckle-tracking echocardiography has been recently demonstrated to be a more accurate and sensitive tool to estimate right ventricular (RV) function. The prognostic value of RVLS in patients with COVID-19 remains unknown. Methods One hundred twenty consecutive patients with COVID-19 who underwent echocardiographic examinations were enrolled in our study. Conventional RV functional parameters, including RV fractional area change, tricuspid annular plane systolic excursion, and tricuspid tissue Doppler annular velocity, were obtained. RVLS was determined using 2-dimensional speckle-tracking echocardiography. RV function was categorized in tertiles of RVLS. Results Compared with patients in the highest RVLS tertile, those in the lowest tertile were more likely to have higher heart rate; elevated levels of D-dimer and C-reactive protein; more high-flow oxygen and invasive mechanical ventilation therapy; higher incidence of acute heart injury, acute respiratory distress syndrome, and deep vein thrombosis; and higher mortality. After a median follow-up period of 51 days, 18 patients died. Compared with survivors, nonsurvivors displayed enlarged right heart chambers, diminished RV function, and elevated pulmonary artery systolic pressure. Male sex, acute respiratory distress syndrome, RVLS, RV fractional area change, and tricuspid annular plane systolic excursion were significant univariate predictors of higher risk for mortality (p < 0.05 for all). A Cox model using RVLS (hazard ratio: 1.33; 95% confidence interval [CI]: 1.15 to 1.53; p < 0.001; Akaike information criterion = 129; C-index = 0.89) was found to predict higher mortality more accurately than a model with RV fractional area change (Akaike information criterion = 142, C-index = 0.84) and tricuspid annular plane systolic excursion (Akaike information criterion = 144, C-index = 0.83). The best cutoff value of RVLS for prediction of outcome was −23% (AUC: 0.87; p < 0.001; sensitivity, 94.4%; specificity, 64.7%). Conclusions RVLS is a powerful predictor of higher mortality in patients with COVID-19. These results support the application of RVLS to identify higher risk patients with COVID-19.
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Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China
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Association of cardiac injury with mortality in hospitalized patients with COVID-19 in Wuhan, China
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Self-citationCardiovascular implications of fatal outcomes of patients with Coronavirus Disease 2019 (COVID-19)
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Self-citationClinical characteristics of 113 deceased patients with coronavirus disease 2019: retrospective study
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COVID-19: Hemoglobin, Iron, and Hypoxia beyond Inflammation. A Narrative Review
Cavezzi, A., Troiani, E., & Corrao, S. (2020) · Clinics and Practice · doi:10.4081/cp.2020.1271 · Cited by 430
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Ng, M.-Y., Ferreira, V. M., Leung, S. T., Yin Lee, J. C., Ho-Tung Fong, A., To Liu, R. W., Man Chan, J. W., Wu, A. K. L., Lung, K.-C., Crean, A. M., et al. (2020) · JACC: Cardiovascular Imaging · doi:10.1016/j.jcmg.2020.08.012 · Cited by 65
Minhas, A. S., Gilotra, N. A., Goerlich, E., Metkus, T., Garibaldi, B. T., Sharma, G., Bavaro, N., Phillip, S., Michos, E. D., & Hays, A. G. (2021) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2021.667721 · Cited by 34
Metadata
- Authors
- Li, Y., Li, H., Zhu, S., Xie, Y., Wang, B., He, L., Zhang, D., Zhang, Y., Yuan, H., Wu, C., Sun, W., Zhang, Y., Li, M., Cui, L., Cai, Y., Wang, J., Yang, Y., Lv, Q., Zhang, L., & Xie, M.
- Venue
- JACC: Cardiovascular Imaging
- Publisher
- Elsevier BV
- Published
- 2020-11
- Volume
- 13
- Issue
- 11
- Pages
- 2287-2299
- ISSN
- 1876-7591 (ISSN-L)
- 1936-878X
- OpenAlex
- W3019718479
- Cited by
- 455
- References
- 23
- FWCI
- 54.61
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Li, Y., Li, H., Zhu, S., Xie, Y., Wang, B., He, L., Zhang, D., Zhang, Y., Yuan, H., Wu, C., Sun, W., Zhang, Y., Li, M., Cui, L., Cai, Y., Wang, J., Yang, Y., Lv, Q., Zhang, L., & Xie, M. (2020). Prognostic Value of Right Ventricular Longitudinal Strain in Patients With COVID-19. JACC: Cardiovascular Imaging. https://doi.org/10.1016/j.jcmg.2020.04.014
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