Statin Therapy Persistence Following Opportunistic Screening for Coronary Artery Calcium on Nongated Chest CTs
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Patient and clinician notifications based on AI-CAC results improved statin prescription and downstream lipid testing, statin persistence, LDL-C reduction and CAD evaluation.
“Patient and clinician notifications based on AI-CAC results improved statin prescription and downstream lipid testing, statin persistence, low-density lipoprotein cholesterol (LDL-C) reduction and CAD evaluation.41–43”
From Prognostication and clinical opportunities with AI for coronary artery calcium: a scoping review (2026) · cites this paper as [43]
The NOTIFY-EXTEND text (page unavailable) reports higher statin initiation with notification in NOTIFY-1, high statin persistence among those who started therapy, lower LDL-C among patients retested, and more CAC scans and stress tests after notification. It says 97 patients underwent repeat lipid testing, but does not show that notification increased lipid testing or improved statin persistence relative to a comparison group. (LLM, conf=0.86)
Experimental — accuracy not yet measuredNotification of patients and clinicians based on AI-CAC results increases cardiovascular preventive discussions, statin prescription rates and statin persistence.
“Notification of patients and clinicians based on these results has been shown to increase cardiovascular preventive discussions, statin prescription rates and statin persistence.40–43”
From Prognostication and clinical opportunities with AI for coronary artery calcium: a scoping review (2026) · cites this paper as [43]
The NOTIFY-EXTEND introduction reports that statin initiation was 51% after notification versus 7% with usual care, supporting an increase in statin prescribing. Its results report documented statin discussions and high persistence at 18 months, but do not establish that notification increased preventive discussions or statin persistence relative to a comparator. No page numbers are provided in our copy. (LLM, conf=0.87)
Experimental — accuracy not yet measuredThree included studies employed an AI algorithm (Bunkerhill Health) in which co-investigator CPL holds equity interest.
“Three included studies41–43 employed an AI algorithm (Bunkerhill Health) in which co-investigator CPL holds equity interest.”
From Prognostication and clinical opportunities with AI for coronary artery calcium: a scoping review (2026) · cites this paper as [43]
The NOTIFY-EXTEND paper states that patients in the underlying NOTIFY-1 project were identified using a deep learning algorithm, supporting the claim that this included study employed AI. Our copy does not identify the algorithm as Bunkerhill Health’s. The statement about CPL’s equity interest concerns the citing authors’ disclosure, not a finding attributed to this source. (LLM, conf=0.82)
Experimental — accuracy not yet measured
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Cites
Näslund, U., Ng, N., Lundgren, A., Fhärm, E., Grönlund, C., Johansson, H., Lindahl, B., Lindahl, B., Lindvall, K., Nilsson, S. K., et al. (2018) · The Lancet · doi:10.1016/s0140-6736(18)32818-6 · Cited by 220 · see citing works
Sandhu, A. T., Rodriguez, F., Ngo, S., Patel, B. N., Mastrodicasa, D., Eng, D., Khandwala, N., Balla, S., Sousa, D., & Maron, D. J. (2023) · Circulation · doi:10.1161/circulationaha.122.062746 · Cited by 174 · see citing works
Self-citationAdherence to Statin Therapy Among US Adults Between 2007 and 2014
Colantonio, L. D., Rosenson, R. S., Deng, L., Monda, K. L., Dai, Y., Farkouh, M. E., Safford, M. M., Philip, K. J., Mues, K. E., & Muntner, P. (2019) · Journal of the American Heart Association · doi:10.1161/jaha.118.010376 · Cited by 153 · see citing works
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Prognostication and clinical opportunities with AI for coronary artery calcium: a scoping review
McDonald, V. J. F., Parsa, S., Mastrodicasa, D., Rodriguez, F., Langlotz, C., Maron, D. J., Sandhu, A. T., Dudum, R., & Jain, S. S. (2026) · BMJ Digital Health & AI · doi:10.1136/bmjdh-2026-000053
Self-citationOpportunistic Coronary Artery Calcium Screening: Time for Clinical Implementation
Rodríguez, F., & Langlotz, C. P. (2026) · Circulation · doi:10.1161/circulationaha.126.081204
Keamy-Minor, E., Dudum, R., Bragdon, C. L., Ngo, S., Xu, S., Asch, S. M., Maron, D. J., Brown-Johnson, C., Sandhu, A. T., & Rodriguez, F. (2026) · American Heart Journal Plus Cardiology Research and Practice · doi:10.1016/j.ahjo.2026.100989
Self-citation
- Authors
- Bouladian, S. G., Ngo, S., Mastrodicasa, D., Eng, D., Khandwala, N., Sousa, D., Chaudhari, A. S., Maron, D. J., Rodriguez, F., & Sandhu, A. T.
- Affiliations
- Stanford Medicine (US)
- University of Washington (US)
- VA Palo Alto Health Care System (US)
- Corresponding author
- Sandhu, Alexander T.
- ORCID
- Venue
- JACC: Cardiovascular Imaging
- Publisher
- Elsevier BV
- Published
- 2025-07
- Volume
- 18
- Issue
- 7
- Pages
- 841-843
- ISSN
- 1876-7591 (ISSN-L)
- 1936-878X
- PMC
- PMC12451966
- OpenAlex
- W4410357664
- Cited by
- 3
- References
- 3
- Citations by year
- 2026: 3
- FWCI
- 1.55
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- JACC. Cardiovascular imaging (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (publishedVersion)
- Funders
- Stanford University
- National Institute of Health
- Topics
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Cardiac Imaging and Diagnostics
- Health Sciences › Medicine › Surgery › Lipoproteins and Cardiovascular Health
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Health Promotion and Cardiovascular Prevention
- Keywords
- statin therapy, treatment persistence, coronary artery calcium, opportunistic screening, cardiovascular risk, secondary prevention
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