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Cited by 638Reconstructive Surgery and Microvascular TechniquesBone Tissue Engineering MaterialsReconstructive Facial Surgery Techniques

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Autologous stem cells (adipose) and fibrin glue used to treat widespread traumatic calvarial defects: case report

Lendeckel, Stefan, Jödicke, Andreas, Christophis, Petros, Heidinger, Kathrin, Wolff, Jan, Fraser, John K., Hedrick, Marc H., Berthold, Lars, Howaldt, Hans-Peter·2004·Journal of Cranio-Maxillofacial Surgery
DOI 10.1016/j.jcms.2004.06.002
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Abstract

This is a report of a 7-year-old girl suffering from widespread calvarial defects after severe head injury with multifragment calvarial fractures, decompressive craniectomy for refractory intracranial hypertension and replantation of cryopreserved skull fragments. Chronic infection resulted in an unstable skull with marked bony defects. Two years after the initial injury the calvarial defects were repaired. Due to the limited amount of autologous cancellous bone available from the iliac crest, autologous adipose derived stem cells were processed simultaneously and applied to the calvarial defects in a single operative procedure. The stem cells were kept in place using autologous fibrin glue. Mechanical fixation was achieved by two large, resorbable macroporous sheets acting as a soft tissue barrier at the same time. The postoperative course was uneventful and CT-scans showed new bone formation and near complete calvarial continuity three months after the reconstruction.

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Metadata

Authors
Lendeckel, S., Jödicke, A., Christophis, P., Heidinger, K., Wolff, J., Fraser, J. K., Hedrick, M. H., Berthold, L., & Howaldt, H.-P.
Affiliations
  • Justus-Liebig-Universität Gießen (DE)
  • University of California, Los Angeles (US)
Corresponding author
Lendeckel, Stefan
ORCID
Venue
Journal of Cranio-Maxillofacial Surgery
Publisher
Elsevier BV
Published
2004-12
Volume
32
Issue
6
Pages
370-373
ISSN
1010-5182 (ISSN-L)
DOI
10.1016/j.jcms.2004.06.002
OpenAlex
W2000994952
Cited by
638
References
0
Citations by year
2026: 5 · 2025: 13 · 2024: 14 · 2023: 17 · 2022: 19 · 2021: 22 · 2020: 26 · 2019: 29 · 2018: 35 · 2017: 33 · 2016: 42 · 2015: 34 · 2014: 47 · 2013: 59 · 2012: 41
FWCI
17.48
Type
journal article
Language
en
Open access
closed
Licence
Locations
  • Journal of Cranio-Maxillofacial Surgery (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Surgery › Reconstructive Surgery and Microvascular Techniques
  • Physical Sciences › Engineering › Biomedical Engineering › Bone Tissue Engineering Materials
  • Health Sciences › Medicine › Surgery › Reconstructive Facial Surgery Techniques
Keywords
adipose-derived stem cells, fibrin glue, calvarial defect, traumatic skull defect, decompressive craniectomy, refractory intracranial hypertension, bone regeneration, pediatric head injury
MeSH terms
Bone Regeneration, Child, Female, Follow-Up Studies, Fracture Fixation, Fractures, Closed, Humans, Membranes, Artificial, Skull Fractures, Tissue Adhesives, Transplantation, Autologous, Wound Healing, Fibrin Tissue Adhesive, Bone Transplantation, Adipocytes, Absorbable Implants, Tissue and Organ Harvesting, Stem Cell Transplantation

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