The DOI matches its Crossref record; 49 of the 50 references it cites were found in a registry or an index.
Clinical Application of Adipose Derived Stem Cells for the Treatment of Aseptic Non-Unions: Current Stage and Future Perspectives—Systematic Review
Open accessAbstract
Fracture non-union is a challenging orthopaedic issue and a socio-economic global burden. Several biological therapies have been introduced to improve traditional surgical approaches. Among these, the latest research has been focusing on adipose tissue as a powerful source of mesenchymal stromal cells, namely, adipose-derived stem cells (ADSCs). ADSC are commonly isolated from the stromal vascular fraction (SVF) of liposuctioned hypodermal adipose tissue, and their applications have been widely investigated in many fields, including non-union fractures among musculoskeletal disorders. This review aims at providing a comprehensive update of the literature on clinical application of ADSCs for the treatment of non-unions in humans. The study was performed according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA). Only three articles met our inclusion criteria, with a total of 12 cases analyzed for demographics and harvesting, potential manufacturing and implantation of ADSCs. The review of the literature suggests that adipose derived cell therapy can represent a promising alternative in bone regenerative medicine for the enhancement of non-unions and bone defects. The low number of manuscripts reporting ADSC-based therapies for long bone fracture healing suggests some critical issues that are discussed in this review. Nevertheless, further investigations on human ADSC therapies are needed to improve the knowledge on their translational potential and to possibly achieve a consensus on their use for such applications.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
There was no incidence of ASCs promoting a pro-tumor tumor microenvironment in the clinical studies of ASCs for non-unions post OS resection.
“Importantly, there was no incidence of ASCs promoting a pro-tumor TME.”
From Mesenchymal Stem/Stromal Cells: Immunomodulatory and Bone Regeneration Potential after Tumor Excision in Osteosarcoma Patients (2023) · cites this paper as [89]
The Discussion (§4.2; page unavailable) reports that the reviewed adipose-derived stem-cell graft studies found no oncological side effects, and the Results (§3; page unavailable) report no further complications beyond those described. That supports an absence of reported clinical oncological events, but the review does not report assessing whether the cells promoted a pro-tumor microenvironment. (LLM, conf=0.84)
Experimental — accuracy not yet measuredIn two clinical studies of ASCs for aseptic non-unions post oncological resection of OS, all patients experienced favorable general clinical outcomes characterized by successful fracture healing and effective filling of bone defects.
“In both studies, it was observed over time that all patients experienced favorable general clinical outcomes characterized by successful fracture healing and effective filling of bone defects [89,107,108].”
From Mesenchymal Stem/Stromal Cells: Immunomodulatory and Bone Regeneration Potential after Tumor Excision in Osteosarcoma Patients (2023) · cites this paper as [89]
The Results (page not provided) report fracture healing and bone-defect filling in patients followed across the included studies. However, three patients did not achieve consolidation and required further surgery, so the claim that all patients healed overstates the review's findings. (LLM, conf=0.90)
Experimental — accuracy not yet measuredScaffold-free ASCs have the ability to promote osteogenesis without oncological side effects short-term (within 3 months) and long-term (up to 4 years) post-transplantation.
“The results showed that scaffold-free ASCs have the ability to promote osteogenesis without oncological side effects short-term (within 3 months) and long-term (up to 4 years) post-transplantation.”
From Mesenchymal Stem/Stromal Cells: Immunomodulatory and Bone Regeneration Potential after Tumor Excision in Osteosarcoma Patients (2023) · cites this paper as [89]
The Discussion (§4.2; page unavailable) reports that scaffold-free adipose-derived grafts helped restore bone anatomy and function in nonunions, with no oncological side effects reported. The Results (§3; page unavailable) give a mean follow-up of about 27 months, but our copy does not establish the claimed short-term (within 3 months) and long-term (up to 4 years) time points. (LLM, conf=0.85)
Experimental — accuracy not yet measuredIn Vériter et al., three osteosarcoma patients who received scaffold-free ASCs post wide bone resection showed adequate bone regrowth filling in the bone defect at 54, 27, and 48 months follow-up, respectively, with no evidence of prolonged inflammation or neoplastic growth.
“In Vériter et al. study, three osteosarcoma patients received scaffold-free ASCs post wide bone resection. In all three patients at the 54, 27, and 48 months follow-up, respectively, there was an adequate bone regrowth filling in the bone defect, with no evidence of prolonged inflammation or neoplastic growth [89,107].”
From Mesenchymal Stem/Stromal Cells: Immunomodulatory and Bone Regeneration Potential after Tumor Excision in Osteosarcoma Patients (2023) · cites this paper as [89]
Split into 2 atoms — 0 confirmed, 2 partially supported, 0 disputed, 0 misattributed, 0 unverifiable. Expand the claim to see per-atom verdicts.
Experimental — accuracy not yet measuredResults from some studies have shown that the use of non-scaffolded MSCs can induce bone regrowth in patients with bone lesions or defects.
“While there has been less research on non-scaffolded ASCs in bone regrowth, results from some studies have shown that the use of non-scaffolded MSCs can induce bone regrowth in patients with bone lesions or defects [89].”
From Mesenchymal Stem/Stromal Cells: Immunomodulatory and Bone Regeneration Potential after Tumor Excision in Osteosarcoma Patients (2023) · cites this paper as [89]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Preferred Reporting Items for Systematic Reviews and Meta-Analyses: the PRISMA statement
Moher, D., Liberati, A., Tetzlaff, J., Altman, D. G., & for the PRISMA Group (2009) · BMJ · doi:10.1136/bmj.b2535 · Cited by 83,823
Preferred Reporting Items for Systematic Reviews and Meta-Analyses: The PRISMA Statement
Moher, D., Liberati, A., Tetzlaff, J., Altman, D. G., & The PRISMA Group (2009) · PLoS Medicine · doi:10.1371/journal.pmed.1000097 · Cited by 64,042
Wang, G., Ma, R., Qiao, G., Wada, K., Aizawa, Y., & Satoh, T. (2015) · Integrative Medicine International · doi:10.1159/000368408 · Cited by 18,762
Dominici, M., Le Blanc, K., Mueller, I., Slaper-Cortenbach, I., Marini, F. C., Krause, D. S., Deans, R. J., Keating, A., Prockop, D. J., & Horwitz, E. M. (2006) · Cytotherapy · doi:10.1080/14653240600855905 · Cited by 17,766
Bone grafts and biomaterials substitutes for bone defect repair: A review
Wang, W., & Yeung, K. (2017) · Bioactive Materials · doi:10.1016/j.bioactmat.2017.05.007 · Cited by 1,972
Bourin, P., Bunnell, B. A., Casteilla, L., Dominici, M., Katz, A. J., March, K. L., Redl, H., Rubin, J. P., Yoshimura, K., & Gimble, J. M. (2013) · Cytotherapy · doi:10.1016/j.jcyt.2013.02.006 · Cited by 1,890 · cited 3×
“in 2013 provided an initial guidance regarding the minimal properties expected for adipose tissue‐derived cells, proposing some markers to phenotype SVF, ADSCs and to assess ADSC functionality [8].”
BackgroundInfluentialBauer, T. W., & Muschler, G. F. (2000) · Clinical Orthopaedics and Related Research · doi:10.1097/00003086-200002000-00003 · Cited by 1,272
Fracture healing: The diamond concept
Giannoudis, P. V., Einhorn, T. A., & Marsh, D. (2007) · Injury · doi:10.1016/s0020-1383(08)70003-2 · Cited by 1,133
Ho-Shui-Ling, A., Bolander, J., Rustom, L. E., Johnson, A. J. W., Luyten, F. P., & Picart, C. (2018) · Biomaterials · doi:10.1016/j.biomaterials.2018.07.017 · Cited by 997
de Grado, G. F., Keller, L., Idoux‐Gillet, Y., Wagner, Q., Musset, A., Benkirane-Jessel, N., Bornert, F., & Offner, D. (2018) · Journal of Tissue Engineering · doi:10.1177/2041731418776819 · Cited by 915
Samavedi, S., Whittington, A. R., & Goldstein, A. S. (2013) · Acta Biomaterialia · doi:10.1016/j.actbio.2013.06.014 · Cited by 830
Epidemiology of Fracture Nonunion in 18 Human Bones
Zura, R., Xiong, Z., Einhorn, T. A., Watson, J. T., Ostrum, R. F., Prayson, M. J., Rocca, G. J. D., Mehta, S. D., McKinley, T. O., Wang, Z., et al. (2016) · JAMA Surgery · doi:10.1001/jamasurg.2016.2775 · Cited by 743
Bone-Graft Substitutes: Facts, Fictions, and Applications
Greenwald, A. S., Boden, S. D., Goldberg, V. M., Khan, Y., Laurencin, C. T., & Rosier, R. N. (2001) · Journal of Bone and Joint Surgery · doi:10.2106/00004623-200100022-00007 · Cited by 702
Delayed union and nonunions: Epidemiology, clinical issues, and financial aspects
Hak, D. J., Fitzpatrick, D., Bishop, J. A., Marsh, J. L., Tilp, S., Schnettler, R., Simpson, H., & Alt, V. (2014) · Injury · doi:10.1016/j.injury.2014.04.002 · Cited by 651
Lendeckel, S., Jödicke, A., Christophis, P., Heidinger, K., Wolff, J., Fraser, J. K., Hedrick, M. H., Berthold, L., & Howaldt, H.-P. (2004) · Journal of Cranio-Maxillofacial Surgery · doi:10.1016/j.jcms.2004.06.002 · Cited by 638
González‐Rey, E., Gonzalez, M. A., Varela, N., O’Valle, F., Hernández‐Cortés, P., Rico, L., Büscher, D., & Delgado, M. (2009) · Annals of the Rheumatic Diseases · doi:10.1136/ard.2008.101881 · Cited by 426
Mizuno, H. (2009) · Journal of Nippon Medical School · doi:10.1272/jnms.76.56 · Cited by 349
Yoon, E., Dhar, S., Chun, D. E., Gharibjanian, N. A., & Evans, G. R. D. (2007) · Tissue Engineering · doi:10.1089/ten.2006.0102 · Cited by 267
Zhang, J., Liu, Y., Chen, Y., Yuan, L., Liu, H., Wang, J., Liu, Q., & Zhang, Y. (2020) · Stem Cells International · doi:10.1155/2020/8810813 · Cited by 219
Bhatt, R., & Rozental, T. D. (2012) · Hand Clinics · doi:10.1016/j.hcl.2012.08.001 · Cited by 191
Adipose-Derived Stem Cells as a Tool in Cell-Based Therapies
Bajek, A., Gurtowska, N., Olkowska, J., Kaźmierski, Ł., Maj, M., & Drewa, T. A. (2016) · Archivum Immunologiae et Therapiae Experimentalis · doi:10.1007/s00005-016-0394-x · Cited by 186
Meza‐Zepeda, L. A., Noer, A., Dahl, J. A., Micci, F., Myklebost, O., & Collas, P. (2007) · Journal of Cellular and Molecular Medicine · doi:10.1111/j.1582-4934.2007.00146.x · Cited by 173
The role of stem cells in fracture healing and nonunion
Fayaz, H. C., Giannoudis, P. V., Vrahas, M. S., Smith, R. M., Moran, C., Pape, H. C., Krettek, C., & Jupiter, J. B. (2011) · International Orthopaedics · doi:10.1007/s00264-011-1338-z · Cited by 160
Health outcomes of delayed union and nonunion of femoral and tibial shaft fractures
Tay, W.-H., de Steiger, R. N., Richardson, M., Gruen, R. L., & Balogh, Z. J. (2014) · Injury · doi:10.1016/j.injury.2014.06.025 · Cited by 156
Stem cells in articular cartilage regeneration
Filardo, G., Perdisa, F., Roffi, A., Marcacci, M., & Kon, E. (2016) · Journal of Orthopaedic Surgery and Research · doi:10.1186/s13018-016-0378-x · Cited by 141
Bone regeneration by implantation of adipose-derived stromal cells expressing BMP-2
Li, H., Dai, K., Tang, T., Zhang, X., Yan, M., & Lou, J. (2007) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2007.02.165 · Cited by 118
Adipose-Derived Mesenchymal Cells for Bone Regereneration: State of the Art
Barba, M., Cicione, C., Bernardini, C., Michetti, F., & Lattanzi, W. (2013) · BioMed Research International · doi:10.1155/2013/416391 · Cited by 102
Self-citationNonunion – consensus from the 4th annual meeting of the Danish Orthopaedic Trauma Society
Schmal, H., Brix, M., Bue, M., Ekman, A., Ferreira, N., Gottlieb, H., Kold, S., Taylor, A., Tengberg, P. T., Ban, I., et al. (2020) · EFORT Open Reviews · doi:10.1302/2058-5241.5.190037 · Cited by 93
Taranto, G. D., Cicione, C., Visconti, G., Isgrò, M. A., Barba, M., Stasio, E. D., Stigliano, E., Bernardini, C., Michetti, F., Salgarello, M., et al. (2015) · Cytotherapy · doi:10.1016/j.jcyt.2015.04.004 · Cited by 86
Self-citationMesenchymal stromal cells multipotency and plasticity: induction toward the hepatic lineage.
Saulnier, N., Lattanzi, W., Puglisi, M. A., Pani, G., Barba, M., Piscaglia, A. C., Giachelia, M., Alfieri, S., Neri, G., Gasbarrini, G., et al. (2009) · PubMed · Cited by 85
Self-citationVériter, S., André, W., Aouassar, N., Poirel, H. A., Lafosse, A., Docquier, P.-L., & Dufrane, D. (2015) · PLOS ONE · doi:10.1371/journal.pone.0139566 · Cited by 78
Principles of Nonunion Management: State of the Art
Nauth, A., Lee, M., Gardner, M. J., Brinker, M. R., Warner, S. J., Tornetta, P., & Leucht, P. (2018) · Journal of Orthopaedic Trauma · doi:10.1097/bot.0000000000001122 · Cited by 75
Adipose-derived stem cell therapies for bone regeneration
Barba, M., Taranto, G. D., & Lattanzi, W. (2017) · Expert Opinion on Biological Therapy · doi:10.1080/14712598.2017.1315403 · Cited by 72
Self-citationMazzoni, E., D’Agostino, A., Iaquinta, M. R., Bononi, I., Trevisiol, L., Rotondo, J. C., Patergnani, S., Giorgi, C., Gunson, M. J., Arnett, G. W., et al. (2019) · Stem Cells Translational Medicine · doi:10.1002/sctm.19-0170 · Cited by 71
Dufrane, D., Docquier, P.-L., Delloye, C., Poirel, H. A., André, W., & Aouassar, N. (2015) · Medicine · doi:10.1097/md.0000000000002220 · Cited by 66
Johnson, L., Igoe, E., Kleftouris, G., Papachristos, I. V., Papakostidis, C., & Giannoudis, P. V. (2019) · Journal of Clinical Medicine · doi:10.3390/jcm8111998 · Cited by 65
Mohiuddin, O. A., Campbell, B. A., Poche, J. N., Ma, M., Rogers, E., Gaupp, D., Harrison, M. A. A., Bunnell, B. A., Hayes, D. J., & Gimble, J. M. (2019) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2019.00211 · Cited by 60
Romero, R., Chubb, L. S., Travers, J. K., Gonzales, T. R., Ehrhart, N. P., & Kipper, M. J. (2015) · Carbohydrate Polymers · doi:10.1016/j.carbpol.2015.01.015 · Cited by 58
Guerrero, J., Pigeot, S., Müller, J., Schaefer, D. J., Martín, I., & Scherberich, A. (2018) · Acta Biomaterialia · doi:10.1016/j.actbio.2018.07.004 · Cited by 38
Undifferentiated Human Adipose Tissue–Derived Stromal Cells Induce Mandibular Bone Healing in Rats
Parrilla, C., Saulnier, N., Bernardini, C., Patti, R., Tartaglione, T., Fetoni, A. R., Pola, E., Paludetti, G., Michetti, F., & Lattanzi, W. (2011) · Archives of Otolaryngology - Head and Neck Surgery · doi:10.1001/archoto.2011.61 · Cited by 32
Self-citationFetoni, A. R., Lattanzi, W., Eramo, S. L. M., Barba, M., Paciello, F., Moriconi, C., Rolesi, R., Michetti, F., Troiani, D., & Paludetti, G. (2014) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2014.00334 · Cited by 25
Self-citationSaçak, B., Certel, F., Akdeniz, Z., Karademir-Yilmaz, B., Ercan, F., Özkan, N., Akpınar, İ., & Çelebïler, Ö. (2016) · Journal of Biomedical Materials Research Part B Applied Biomaterials · doi:10.1002/jbm.b.33634 · Cited by 25
Cicione, C., Taranto, G. D., Barba, M., Isgrò, M. A., D’Alessio, A., Cervelli, D., Sciarretta, F. V., Pelo, S., Michetti, F., & Lattanzi, W. (2016) · Plastic & Reconstructive Surgery · doi:10.1097/prs.0000000000002014 · Cited by 23
Self-citationAutologous fat transplantation for the treatment of trapeziometacarpal joint osteoarthritis
Bonetti, M. A., Rovere, G., Fulchignoni, C., Santis, V. D., Ziranu, A., Maccauro, G., & Pataia, E. (2020) · Orthopedic Reviews · doi:10.4081/or.2020.8666 · Cited by 19
Self-citationTreatment options for aseptic tibial diaphyseal nonunion: A review of selected studies
Gálvez-Sirvent, E., Ibarzábal-Gil, A., & Rodriguez-Merchan, E. C. (2020) · EFORT Open Reviews · doi:10.1302/2058-5241.5.190077 · Cited by 19
Song, J., Kim, Y., Kweon, O., & Kang, B. (2017) · Journal of Veterinary Science · doi:10.4142/jvs.2017.18.4.555 · Cited by 14
Mocini, F., Monteleone, A. S., Piazza, P., Cardona, V., Vismara, V., Messinese, P., Campana, V., Sircana, G., Maccauro, G., & Saccomanno, M. F. (2020) · Orthopedic Reviews · doi:10.4081/or.2020.8682 · Cited by 12
Self-citationKhalpey, Z. I., Marsh, K. M., Ferng, A. S., Riaz, I. B., Hemphill, C., Johnson, K., Oliva, I., & Friedman, M. J. (2015) · ASAIO Journal · doi:10.1097/mat.0000000000000236 · Cited by 12
Bone Regeneration with a Combination of Adipose-Derived Stem Cells and Platelet-Rich Plasma
Tajima, S., Tobita, M., & Mizuno, H. (2018) · Methods in molecular biology · doi:10.1007/978-1-4939-7799-4_20 · Cited by 9
Flagged first, then by citations
1 of the 50 references couldn’t be matched to a known paper.
Cited by
Sorted by citations
Adipose-derived mesenchymal stem cells (MSCs) are a superior cell source for bone tissue engineering
Gou, Y., Huang, Y., Luo, W., Li, Y., Zhao, P., Zhong, J., Dong, X., Guo, M., Li, A., Hao, A., et al. (2023) · Bioactive Materials · doi:10.1016/j.bioactmat.2023.12.003 · Cited by 81
Recent advances in the management of knee osteoarthritis: a narrative review
Shtroblia, V., Petakh, P., Kamyshna, I. I., Halabitska, I., & Kamyshnyi, O. (2025) · Frontiers in Medicine · doi:10.3389/fmed.2025.1523027 · Cited by 70
Suchanecka, M., Grzelak, J., Farzaneh, M., Azizidoost, S., Dari, M. A. G., Józkowiak, M., Data, K., Domagała, D., Niebora, J., Kotrych, K., et al. (2025) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2025.118036 · Cited by 48
Adipose-derived stem cell exosomes: mechanisms and therapeutic potentials in wound healing
Feng, H., Gong, S., Liu, J., Aghayants, S., Liu, Y., Wu, M., Wu, Y., & Song, J. (2025) · Biomarker Research · doi:10.1186/s40364-025-00801-2 · Cited by 45
Owida, H. A. (2022) · Advances in Orthopedics · doi:10.1155/2022/8670174 · Cited by 26
Baron, M., Drohat, P., Crawford, B., Hornicek, F. J., Best, T. M., & Kouroupis, D. (2023) · Bioengineering · doi:10.3390/bioengineering10101187 · Cited by 19
Cui, C., Lin, F., Xia, L., & Zhang, X. (2025) · BMC Musculoskeletal Disorders · doi:10.1186/s12891-025-08365-w · Cited by 17
Rovere, G., Mauro, D. D., Smakaj, A., Sassara, G. M., VITIS, R. D., Farsetti, P., Camarda, L. K. C., Maccauro, G., & Liuzza, F. (2024) · Frontiers in Surgery · doi:10.3389/fsurg.2024.1266393 · Cited by 14
Self-citationPietro, L. D., Palmieri, V., Papi, M., & Lattanzi, W. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23169493 · Cited by 14
Self-citationRecent trends of stem cell therapies in the management of orthopedic surgical challenges
Pal, D., Das, P., Roy, S., Mukherjee, P., Halder, S., Ghosh, D., & Nandi, S. K. (2024) · International Journal of Surgery · doi:10.1097/js9.0000000000001524 · Cited by 10
Mbiine, R., Kayiira, A., Wayengera, M., Munabi, I. G., Kiwanuka, N., Alenyo, R., Kalanzi, E. W., Muwonge, H., Nakanwagi, C., Joloba, M. L., et al. (2021) · Research Square · doi:10.21203/rs.3.rs-940210/v1 · Cited by 8
Cioffi, A., Rovere, G., Bosco, F., Sinno, E., Stramazzo, L., Liuzza, F., Ziranu, A., Romeo, M., Vigni, G. E., Galvano, N., et al. (2023) · Healthcare · doi:10.3390/healthcare11243123 · Cited by 7
Self-citationGu, C., Tang, Q., Li, L., & Chen, Y. (2024) · Bioengineering · doi:10.3390/bioengineering11111100 · Cited by 7
Lin, C.-Y. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms231911377 · Cited by 6
Jin, Y.-X., & Jin, G. (2025) · Clinical Cosmetic and Investigational Dermatology · doi:10.2147/ccid.s547675 · Cited by 5
Gładyś, A., Mazurski, A., & Czekaj, P. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25147806 · Cited by 4
Banu, S. A., Sharun, K., Mamachan, M., Manjusha, K. M., Emmanuel, R. S., Tomy, A., Chandra, V., Sharma, G. K., PAWDE, A. M., Maiti, S. K., et al. (2025) · The Journal of Basic and Applied Zoology · doi:10.1186/s41936-025-00462-5 · Cited by 3
von Matthey, F., Rammensee, J. R., Biberthaler, P., & Abel, H. (2023) · Journal of Clinical Medicine · doi:10.3390/jcm12031202 · Cited by 2
Coviello, M., Meccariello, L., Rovere, G., Caiaffa, V., Rollo, G., Liuzza, F., Ronga, M., Ippolito, F., Smakaj, A., MANCINI, M. L., et al. (2026) · Journal of Functional Morphology and Kinesiology · doi:10.3390/jfmk11020239 · Cited by 2
Self-citationSimoncic, B., Dimitrijević, M., Juloski, J., & Vulicevic, Z. R. (2022) · Srpski arhiv za celokupno lekarstvo · doi:10.2298/sarh220505089s · Cited by 2
Anastasio, A. T., Bagheri, K., & Adams, S. B. (2023) · Foot & Ankle Orthopaedics · doi:10.1177/24730114231207643 · Cited by 1
Vorontsov, P., & Maltseva, V. (2024) · ORTHOPAEDICS TRAUMATOLOGY and PROSTHETICS · doi:10.15674/0030-59872024281-87 · Cited by 1
Mauro, D. D., Aprato, A., Bove, F., Mezzadri, U. M. R., Giorgi, P. D., Casiraghi, A., Galante, C., Erasmo, R., Santolini, F., Formica, M., et al. (2024) · Injury · doi:10.1016/j.injury.2024.111398 · Cited by 1
Self-citationBoutros, M., Awad, G., Kattan, G., Azar, J., Boudani, D., & Babar, S. (2025) · European Journal of Orthopaedic Surgery & Traumatology · doi:10.1007/s00590-025-04603-y · Cited by 1
Biomaterials for clinical therapy utilizing cells differentiated from human pluripotent stem cells
Higuchi, A., Wang, T., Kang, X., Tian, Z., Sung, T., & Umezawa, A. (2026) · Materials Today Advances · doi:10.1016/j.mtadv.2026.100860 · Cited by 1
Rovere, G., Smakaj, A., Rollo, G., Ronga, M., Quassone, P., Perna, A., Liuzza, F., Maio, F. D., Fidanza, A., Coviello, M., et al. (2026) · Acta bio-medica dell'Ateneo parmense/Acta biomedica · doi:10.23750/abm.2026.18021 · Cited by 1
Self-citationMartins-Santos, R., Kronemberger, G. S., Baptista, L. S., Taichman, R. S., Granjeiro, J. M., & Duarte, M. E. L. (2023) · Elsevier eBooks · doi:10.1016/b978-0-443-15289-4.00012-3 · Cited by 1
Yumuşak doku patolojilerinde rejeneratif yöntemlerin kullanımı
Genç, E., & Uslu, M. (2022) · Türk Ortopedi ve Travmatoloji Birliği Derneği · doi:10.5578/totbid.dergisi.2022.79
Thoracic synovial cyst as cause of cord compression in a patient with Charcot-Marie-Tooth disease.
Mauro, D. D., Cicia, A., Meluzio, M. C., Grillo, G., Smakaj, A., Perna, A., & Tamburrelli, F. C. (2023) · Acta bio-medica dell'Ateneo parmense/Acta biomedica · doi:10.23750/abm.v94is2.12521
Self-citationWang, S., Tan, L., & Sheng, B. (2024) · Frontiers in Surgery · doi:10.3389/fsurg.2024.1437290
Szabłowska‐Gadomska, I., Rudziński, S., Mroczko, A., Mrozikiewicz-Rakowska, B., Cysewski, D., Gasperowicz, P., & Bocian, K. (2026) · Cells · doi:10.3390/cells15070614
Zhang, Y., Yu, S., Chen, Y., Gao, Y., & Ma, X. (2026) · Stem Cells International · doi:10.1155/sci/2552466
Metadata
- Authors
- Smakaj, A., De Mauro, D., Rovere, G., Pietramala, S., Maccauro, G., Parolini, O., Lattanzi, W., & Liuzza, F.
- Affiliations
- Università Cattolica del Sacro Cuore (IT)
- Department of Aging, Neurological, Orthopaedic and Head-Neck Sciences, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, 00168 Rome, Italy
- Agostino Gemelli University Polyclinic (IT)
- Corresponding author
- Lattanzi, Wanda
- Liuzza, Francesco
- ORCID
- Venue
- International Journal of Molecular Sciences
- Publisher
- MDPI AG
- Published
- 2022-03-11
- Volume
- 23
- Issue
- 6
- Pages
- 3057
- ISSN
- 1422-0067 (ISSN-L)
- PMC
- PMC8950719
- OpenAlex
- W4220746626
- Cited by
- 31
- References
- 50
- Citations by year
- 2026: 4 · 2025: 7 · 2024: 8 · 2023: 7 · 2022: 5
- FWCI
- 1.12
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- International Journal of Molecular Sciences (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Cineca Institutional Research Information System (Tor Vergata University) (submittedVersion, cc-by)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- PubliCatt (Università Cattolica del Sacro Cuore) (submittedVersion, cc-by)
- Funders
- Università Cattolica del Sacro Cuore
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Mesenchymal stem cell research
- Health Sciences › Medicine › Orthopedics and Sports Medicine › Bone fractures and treatments
- Physical Sciences › Engineering › Biomedical Engineering › Bone Tissue Engineering Materials
- Keywords
- adipose-derived stem cells, aseptic nonunion, nonunion, mesenchymal stem cells, stromal vascular fraction, cell therapy, bone regeneration, bone defects, clinical application
- MeSH terms
- Adipose Tissue, Humans, Adipocytes, Regenerative Medicine, Mesenchymal Stem Cells, Cell- and Tissue-Based Therapy
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
