The DOI matches its Crossref record; 49 of the 50 references it cites were found in a registry or an index.
Thermosensitive and biodegradable polymeric micelles for paclitaxel delivery
Abstract
The preparation, release and in vitro cytotoxicity of a novel polymeric micellar formulation of paclitaxel (PTX) were investigated. The micelles consisted of an AB block copolymer of poly(N-(2-hydroxypropyl) methacrylamide lactate) and poly(ethylene glycol) (pHPMAmDL-b-PEG). Taking advantage of the thermosensitivity of pHPMAmDL-b-PEG, the loading was done by simply mixing of a small volume of a concentrated PTX solution in ethanol and an aqueous polymer solution and subsequent heating of the resulting solution above the critical micelle temperature of the polymer. PTX could be almost quantitatively loaded in the micelles up to 2 mg/mL. By dynamic light scattering and cryo-transmission electron microscopy, it was shown that PTX-loaded micelles have a mean size around 60 nm with narrow size distribution. At pH 8.8 and 37 degrees C, PTX-loaded micelles destabilized within 10 h due to the hydrolysis of the lactic acid side group of the pHPMAmDL. Because the hydrolysis of the lactic acid side groups is first order in hydroxyl ion concentration, the micelles were stable for about 200 h at physiological conditions. The presence of serum proteins did not have an adverse effect on the stability of the micelles during at least 15 h. Interestingly, the dissolution kinetics of pHPMAmDL-b-PEG micelles was retarded by incorporation of PTX, indicating a strong interaction between PTX and the pHPMAmDL block. The PTX-loaded micelles showed a release of the incorporated 70% of PTX during 20 h at 37 degrees C and at pH 7.4. PTX-loaded pHPMAmDL-b-PEG micelles showed comparable in vitro cytotoxicity against B16F10 cells compared to the Taxol standard formulation containing Cremophor EL, while pHPMAmDL-b-PEG micelles without PTX were far less toxic than the Cremophor EL vehicle. Confocal laser-scanning microscopy (CLSM) and fluorescence activated cell sorting (FACS) analysis of fluorescently labelled micelles showed that pHPMAmDL-b-PEG micelles were internalized by the B16F10 cells. The present results suggest that pHPMAmDL-b-PEG block copolymer micelles are a promising delivery system for the parenteral administration of PTX.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“standard TEM can have interesting application for the determination of the cellular fate of micelles labeled with heavy atoms such as gold [90,172] or radioactive probes [90].”
From Polymeric micelles in drug delivery: An insight of the techniques for their characterization and assessment in biorelevant conditions (2021) · cites this paper as [172]
Citations
Cites
Tumor vascular permeability and the EPR effect in macromolecular therapeutics: a review
Maeda, H., Wu, J., Sawa, T., Matsumura, Y., & Hori, K. (2000) · Journal of Controlled Release · doi:10.1016/s0168-3659(99)00248-5 · Cited by 6,565
Block copolymer micelles for drug delivery: design, characterization and biological significance
Kataoka, K., Harada, A., & Nagasaki, Y. (2001) · Advanced Drug Delivery Reviews · doi:10.1016/s0169-409x(00)00124-1 · Cited by 3,506
Scudiero, D. A., Shoemaker, R. H., Paull, K. D., Monks, A. P., Tierney, S., Nofziger, T. H., Currens, M. J., Seniff, D. A., & Boyd, M. R. (1988) · PubMed · Cited by 2,342
Rowinsky, E. K., & Donehower, R. C. (1995) · New England Journal of Medicine · doi:10.1056/nejm199504133321507 · Cited by 1,924
Gelderblom, H. A. J., Verweij, J., Nooter, K., & Sparreboom, A. (2001) · European Journal of Cancer · doi:10.1016/s0959-8049(01)00171-x · Cited by 1,659
Nano-engineering block copolymer aggregates for drug delivery
Allen, C., Maysinger, D., & Eisenberg, A. (1999) · Colloids and Surfaces B: Biointerfaces · doi:10.1016/s0927-7765(99)00058-2 · Cited by 1,358
Bae, Y., Fukushima, S., Harada, A., & Kataoka, K. (2003) · Angewandte Chemie International Edition · doi:10.1002/anie.200250653 · Cited by 1,329
Polymeric micelles—A new generation of colloidal drug carriers
Jones, M.-C., & Leroux, J.-C. (1999) · European Journal of Pharmaceutics and Biopharmaceutics · doi:10.1016/s0939-6411(99)00039-9 · Cited by 1,256
Micellar Nanocontainers Distribute to Defined Cytoplasmic Organelles
Savić, R., Luo, L., Eisenberg, A., & Maysinger, D. (2003) · Science · doi:10.1126/science.1078192 · Cited by 1,113
Fonseca, C., Simões, S., & Gaspar, R. S. (2002) · Journal of Controlled Release · doi:10.1016/s0168-3659(02)00212-2 · Cited by 770
Flagged first, then by citations
1 of the 50 references couldn’t be matched to a known paper.
Cited by
Sorted by citations
Items 101–200 of 318
Novel Acid‐Labile, Thermoresponsive Poly(methacrylamide)s with Pendent Ortho Ester Moieties
Huang, X., Du, F., Ju, R., & Li, Z. (2007) · Macromolecular Rapid Communications · doi:10.1002/marc.200600798 · Cited by 67
Naruphontjirakul, P., & Viravaidya‐Pasuwat, K. (2019) · International Journal of Nanomedicine · doi:10.2147/ijn.s198552 · Cited by 67
Nanoaggregate of thermosensitive chitosan-Pluronic for sustained release of hydrophobic drug
Park, K., Bae, J. W., Joung, Y. K., Shin, J. W., & Park, K. D. (2008) · Colloids and Surfaces B Biointerfaces · doi:10.1016/j.colsurfb.2007.10.024 · Cited by 65
Interactions between an Anticancer Drug and Polymeric Micelles Based on Biodegradable Polyesters
Yang, X., Zhu, B., Dong, T., Pan, P., Shuai, X., & Inoue, Y. (2008) · Macromolecular Bioscience · doi:10.1002/mabi.200800085 · Cited by 62
Sutton, D. M., Wang, S., Nasongkla, N., Gao, J., & Dormidontova, E. E. (2007) · Experimental Biology and Medicine · doi:10.3181/0702-rm-31 · Cited by 62
van Hasselt, P. M., Janssens, G. E. P. J., Slot, T. K., van der Ham, M., Minderhoud, T. C., Talelli, M., Akkermans, L. M., Rijcken, C. J. F., & van Nostrum, C. F. (2009) · Journal of Controlled Release · doi:10.1016/j.jconrel.2008.09.089 · Cited by 60
Polymers for targeted and/or sustained drug delivery
Jagur‐Grodzinski, J. (2008) · Polymers for Advanced Technologies · doi:10.1002/pat.1304 · Cited by 60
Hou, L., Fan, Y., Yao, J., Zhou, J., Li, C., Fang, Z., & Zhang, Q. (2011) · Carbohydrate Polymers · doi:10.1016/j.carbpol.2011.06.008 · Cited by 60
Talelli, M., Morita, K., Rijcken, C. J. F., Aben, R. W. M., Lammers, T., Scheeren, H. W., van Nostrum, C. F., Storm, G., & Hennink, W. E. (2011) · Bioconjugate Chemistry · doi:10.1021/bc2003499 · Cited by 61
Louage, B., Zhang, Q., Vanparijs, N., Voorhaar, L., Casteele, S. V., Shi, Y., Hennink, W. E., Bocxlaer, J. V., Hoogenboom, R., & Geest, B. G. D. (2014) · Biomacromolecules · doi:10.1021/bm5015409 · Cited by 58
Thermoresponsive polymers as gene and drug delivery vectors: architecture and mechanism of action
Calejo, M. T., Sande, S. A., & Nyström, B. (2013) · Expert Opinion on Drug Delivery · doi:10.1517/17425247.2013.846906 · Cited by 58
Polymeric micelles for cancer therapy: 3 C’s to enhance efficacy
Talelli, M., Rijcken, C. J. F., Hennink, W. E., & Lammers, T. (2012) · Current Opinion in Solid State and Materials Science · doi:10.1016/j.cossms.2012.10.003 · Cited by 55
Choi, J., Cho, N. H., Kim, D.-H., & Park, J. (2019) · Materials Science and Engineering C · doi:10.1016/j.msec.2019.03.002 · Cited by 57
pH-Responsive Nano-Self-Assemblies of the Anticancer Drug 2-Hydroxyoleic Acid
Prajapati, R., Gontsarik, M., Yaghmur, A., & Salentinig, S. (2019) · Langmuir · doi:10.1021/acs.langmuir.9b00838 · Cited by 57
Grinberg, O., Hayun, M., Sredni, B., & Gedanken, A. (2007) · Ultrasonics Sonochemistry · doi:10.1016/j.ultsonch.2006.11.004 · Cited by 56
Triple-stimuli (pH/thermo/reduction) sensitive copolymers for intracellular drug delivery
Huang, X., Jiang, X., Yang, Q., Chu, Y., Zhang, G., Yang, B., & Zhuo, R. (2013) · Journal of Materials Chemistry B · doi:10.1039/c3tb00424d · Cited by 56
Development of docetaxel nanocrystals surface modified with transferrin for tumor targeting
Choi, J., & Park, J. (2016) · Drug Design Development and Therapy · doi:10.2147/dddt.s122984 · Cited by 56
Li, Q., & Yan, M. Q. (2009) · Acta Biomaterialia · doi:10.1016/j.actbio.2009.02.005 · Cited by 55
Controlling Subcellular Delivery to Optimize Therapeutic Effect
Mossalam, M., Dixon, A. S., & Lim, C. S. (2010) · Therapeutic Delivery · doi:10.4155/tde.10.8 · Cited by 54
Stabilized polymeric micelles by electrostatic interactions for drug delivery system
Cha, E., Kim, J. E., & Ahn, C. (2009) · European Journal of Pharmaceutical Sciences · doi:10.1016/j.ejps.2009.08.006 · Cited by 51
A hyperbranched amphiphilic acetal polymer for pH-sensitive drug delivery
Cao, H., Chen, C., Xie, D., Chen, X., Wang, P., Wang, Y., Song, H., & Wang, W. (2018) · Polymer Chemistry · doi:10.1039/c7py01739a · Cited by 50
Development and evaluation of targeting ligands surface modified paclitaxel nanocrystals.
Sohn, J., Yoon, D.-S., Sohn, J., Park, J.-S., & Choi, J.-S. (2017) · Materials Science and Engineering C: Materials for Biological Applications · doi:10.1016/j.msec.2016.11.065 · Cited by 49
Hierarchical Supermolecular Structures for Sustained Drug Release
Tan, J. P. K., Kim, S. H., Nederberg, F., Appel, E. A., Waymouth, R. M., Zhang, Y., Hedrick, J. L., & Yang, Y. Y. (2009) · Small · doi:10.1002/smll.200801756 · Cited by 48
The potential of polymeric micelles in the context of glioblastoma therapy
Morshed, R. A., Cheng, Y., Auffinger, B., Wegscheid, M. L., & Lesniak, M. S. (2013) · Frontiers in Pharmacology · doi:10.3389/fphar.2013.00157 · Cited by 51
Developments and future clinical outlook of taxane nanomedicines
Louage, B., Wever, O. D., Hennink, W. E., & Geest, B. G. D. (2017) · Journal of Controlled Release · doi:10.1016/j.jconrel.2017.03.027 · Cited by 50
Guerin, J., Burgain, J., Gomand, F., Scher, J., & Gaïani, C. (2017) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2017.1386158 · Cited by 49
Jin, Q., Lv, L., Liu, G., Xu, J., & Ji, J. (2010) · Polymer · doi:10.1016/j.polymer.2010.04.061 · Cited by 48
Zhang, L., Lu, Z., Li, X., Deng, Y., Zhang, F., Ma, C., & He, N. (2012) · Polymer Chemistry · doi:10.1039/c2py20201h · Cited by 48
Hu, Q., Rijcken, C. J. F., van Gaal, E. V. B., Brundel, P., Kostková, H., Etrych, T., Weber, B., Barz, M., Kiessling, F. M., Prakash, J., et al. (2016) · Journal of Controlled Release · doi:10.1016/j.jconrel.2016.07.012 · Cited by 48
Gao, Y., Nai, J., Yang, Z., Zhang, J., Ma, S., Zhao, Y., Li, H., Li, J., Yang, Y., Yang, M., et al. (2021) · PLoS ONE · doi:10.1371/journal.pone.0250670 · Cited by 48
Interaction and Complexation of Phospholipid Vesicles and Triblock Copolymers
Chieng, Y. Y., & Chen, S. B. (2009) · The Journal of Physical Chemistry B · doi:10.1021/jp906929u · Cited by 47
Topically applied liposome-in-hydrogels for systematically targeted tumor photothermal therapy
Chen, G., Ullah, A., Xu, G., Xu, Z., Wang, F., Liu, T., Su, Y., Zhang, T., & Wang, K. (2021) · Drug Delivery · doi:10.1080/10717544.2021.1974607 · Cited by 46
Huo, M., Liu, Y., Wang, L., Yin, T., Qin, C., Xiao, Y., Yin, L., Liu, J., & Zhou, J. (2016) · Molecular Pharmaceutics · doi:10.1021/acs.molpharmaceut.5b00696 · Cited by 46
Wang, Z., Ling, L., Du, Y., Yao, C., & Li, X. (2019) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2019.04.060 · Cited by 47
Sani, A., Pourmadadi, M., Shaghaghi, M., Eshaghi, M. M., Shahmollaghamsary, S., Arshad, R., Fathi‐karkan, S., Rahdar, A., Medina, D. I., & Pandey, S. (2023) · Journal of Drug Delivery Science and Technology · doi:10.1016/j.jddst.2023.104642 · Cited by 45
Shi, Y., van den Dungen, E. T. A., Klumperman, B., van Nostrum, C. F., & Hennink, W. E. (2013) · ACS Macro Letters · doi:10.1021/mz300662b · Cited by 45
Yu, Y. C., Li, G., Kim, J., & Youk, J. H. (2013) · Polymer · doi:10.1016/j.polymer.2013.09.013 · Cited by 45
Lee, J. S., & Feijén, J. (2011) · Journal of Controlled Release · doi:10.1016/j.jconrel.2011.10.025 · Cited by 45
Zheng, N., Dai, W., Du, W., Zhang, H., Lei, L., Zhang, H., Wang, X., Wang, J., Zhang, X., Gao, J., et al. (2012) · Molecular Pharmaceutics · doi:10.1021/mp200464x · Cited by 43
pH-responsive zwitterionic polypeptide as a platform for anti-tumor drug delivery
Liu, N., Han, J., Zhang, X., Yang, Y., Liu, Y., Wang, Y., & Wu, G. (2016) · Colloids and Surfaces B Biointerfaces · doi:10.1016/j.colsurfb.2016.05.027 · Cited by 43
Rani, S., Gothwal, A., Khan, I., Pachouri, P. K., Bhaskar, N., Gupta, U. D., Chauhan, D. S., & Gupta, U. D. (2018) · AAPS PharmSciTech · doi:10.1208/s12249-018-1151-8 · Cited by 41
Vihola, H., Marttila, A.-M., PAKKANEN, J., Andersson, M. R., Laukkanen, A., Kaukonen, A. M., Tenhu, H. J., & Hirvonen, J. J. (2007) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2007.04.020 · Cited by 43
Zhang, W., Zheng, X., Shen, S., & Wang, X. (2015) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2015.09.036 · Cited by 40
Geyik, C., Çiftçi, M., Demir, B., Güler, B. A., Özkaya, A. B., Gümüş, Z. P., Barlas, F. B., Demirkol, D. O., Çoşkunol, H., Tımur, S., et al. (2015) · Polymer Chemistry · doi:10.1039/c5py00780a · Cited by 40
Wang, W., Li, M., Zhang, Z., Cui, C., Zhou, J., Yin, L., & Lv, H. (2016) · Carbohydrate Polymers · doi:10.1016/j.carbpol.2016.08.100 · Cited by 40
In vivoanti-tumor efficacy of docetaxel-loaded thermally responsive nanohydrogel
Zhang, J., Qian, Z., & Gu, Y. (2009) · Nanotechnology · doi:10.1088/0957-4484/20/32/325102 · Cited by 40
Krimmer, S. G., Pan, H., Liu, J., Yang, J., & Kopec̆ek, J. (2011) · Macromolecular Bioscience · doi:10.1002/mabi.201100019 · Cited by 38
Fang, J., Chen, J., Leu, Y., & Hu, J. (2008) · Drug Delivery · doi:10.1080/10717540802006674 · Cited by 38
Multifunctional nanomicellar systems for delivering anticancer drugs
Chen, Y., Lo, C.-L., & Hsiue, G. (2013) · Journal of Biomedical Materials Research Part A · doi:10.1002/jbm.a.34850 · Cited by 37
Biodegradable ‘intelligent’ materials in response to chemical stimuli for biomedical applications
Ju, X., Xie, R., Yang, L., & Chu, L. (2009) · Expert Opinion on Therapeutic Patents · doi:10.1517/13543770902769617 · Cited by 37
Polyelectrolyte multilayer nanoshells with hydrophobic nanodomains for delivery of Paclitaxel.
Boudou, T., Kharkar, P. M., Jing, J., Guillot, R., Pignot‐Paintrand, I., Auzély‐Velty, R., & Picart, C. (2012) · PubMed · doi:10.1016/j.jconrel.2012.01.022 · Cited by 36
Abolmaali, S. S., Tamaddon, A. M., Salmanpour, M., Mohammadi, S., & Dinarvand, R. (2017) · European Journal of Pharmaceutical Sciences · doi:10.1016/j.ejps.2017.04.009 · Cited by 38
Polymeric Micelles for the Delivery of Poorly Soluble Drugs
Biswas, S., Vaze, O. S., Movassaghian, S., & Torchilin, V. P. (2013) · Wiley eBooks · doi:10.1002/9781118444726.ch14 · Cited by 37
Effects of paclitaxel nanocrystals surface charge on cell internalization
Choi, J., & Park, J. (2016) · European Journal of Pharmaceutical Sciences · doi:10.1016/j.ejps.2016.08.014 · Cited by 33
Nanomicelles in Diagnosis and Drug Delivery∗
Trinh, H. M., Joseph, M. A., Cholkar, K., Mitra, R., & Mitra, A. K. (2017) · Elsevier eBooks · doi:10.1016/b978-0-323-42978-8.00003-6 · Cited by 33
Vinyl Polymer-based technologies towards the efficient delivery of chemotherapeutic drugs
Pereira, P., Serra, A. C., & Coelho, J. F. J. (2021) · Progress in Polymer Science · doi:10.1016/j.progpolymsci.2021.101432 · Cited by 33
Controlled release of ionic drug through the positively charged temperature-responsive membranes
Zhang, L., Xu, T., & Lin, Z. (2006) · Journal of Membrane Science · doi:10.1016/j.memsci.2006.04.018 · Cited by 32
Jiang, X., Li, L., Liu, J. P., Hennink, W. E., & Zhuo, R. (2012) · Macromolecular Bioscience · doi:10.1002/mabi.201100459 · Cited by 32
Controlled Delivery of Functionalized Gold Nanoparticles by pH-Sensitive Polymersomes
Popescu, M.-T., & Tsitsilianis, C. (2013) · ACS Macro Letters · doi:10.1021/mz300637c · Cited by 32
Talelli, M., Rijcken, C. J. F., Oliveira, S., van der Meel, R., Henegouwen, P. M. P. V. B. E., Lammers, T., van Nostrum, C. F., Storm, G., & Hennink, W. E. (2011) · Journal of Controlled Release · doi:10.1016/j.jconrel.2011.06.003 · Cited by 32
Anthracene functionalized thermosensitive and UV-crosslinkable polymeric micelles
Shi, Y., Cardoso, R. M., van Nostrum, C. F., & Hennink, W. E. (2015) · Polymer Chemistry · doi:10.1039/c4py01759e · Cited by 31
Huang, Y., Sun, R., Luo, Q., Wang, Y., Zhang, K., Deng, X., Zhu, W., Li, X., & Shen, Z. (2015) · Journal of Polymer Science Part A Polymer Chemistry · doi:10.1002/pola.27778 · Cited by 31
Khonkarn, R., Mankhetkorn, S., Talelli, M., Hennink, W. E., & Okonogi, S. (2012) · Colloids and Surfaces B Biointerfaces · doi:10.1016/j.colsurfb.2012.02.002 · Cited by 31
Interfacial engineering of nanoparticles for cancer therapeutics
Rana, S., Bhattacharjee, J., Barick, K. C., Verma, G., Hassan, P. A., & Yakhmi, J. V. (2017) · Elsevier eBooks · doi:10.1016/b978-0-323-46144-3.00007-6 · Cited by 33
Amphiphilic Scorpion-like Macromolecules as Micellar Nanocarriers
Djordjevic, J., del Rosario, L. S., Wang, J., & Uhrich, K. E. (2008) · Journal of Bioactive and Compatible Polymers · doi:10.1177/0883911508097498 · Cited by 30
Vader, P., Fens, M. H. A. M., Sachini, N., van Oirschot, B. A., Andringa, G., Egberts, T. C. G., Gaillard, S., Rasmussen, J. T., van Wijk, R., van Solinge, W. W., et al. (2013) · Nanomedicine · doi:10.2217/nnm.12.163 · Cited by 30
Makhmalzadeh, B. S., Molavi, O., Vakili, M. R., Zhang, H., Solimani, A., Abyaneh, H. S., Löebenberg, R., Lai, R. L., & Lavasanifar, A. (2018) · Journal of Pharmacy & Pharmaceutical Sciences · doi:10.18433/jpps29726 · Cited by 31
Kalarikkal, S. P., Kumar, M. N., Rajendran, S., Bethi, C. M. S., Ravilla, J., Janakiraman, N., & Sundaram, G. M. (2025) · iScience · doi:10.1016/j.isci.2025.112556 · Cited by 31
Lin, S. (2019) · Journal of Controlled Release · doi:10.1016/j.jconrel.2019.12.046 · Cited by 30
Biodegradable ‘intelligent’ materials in response to physical stimuli for biomedical applications
Ju, X., Xie, R., Yang, L., & Chu, L. (2009) · Expert Opinion on Therapeutic Patents · doi:10.1517/13543770902771282 · Cited by 29
Pluronic/chitosan shell cross-linked nanocapsules encapsulating magnetic nanoparticles
Bae, K. H., Ha, Y. J., Kim, C.-S., Lee, K., & Park, T. G. (2008) · Journal of Biomaterials Science Polymer Edition · doi:10.1163/156856208786440451 · Cited by 29
Wei, Y., Ma, L., Zhang, L., & Xu, X. (2017) · International Journal of Nanomedicine · doi:10.2147/ijn.s144322 · Cited by 27
Buwalda, S. J., Nottelet, B., Béthry, A., Kok, R. J., Sijbrandi, N. J., & Coudane, J. (2018) · Journal of Colloid and Interface Science · doi:10.1016/j.jcis.2018.10.001 · Cited by 28
Ultrasound-Mediated Drug Delivery in Cancer Therapy: A Review
AlSawaftah, N., & Husseini, G. A. (2020) · Journal of Nanoscience and Nanotechnology · doi:10.1166/jnn.2020.18877 · Cited by 28
Acid‐labile, thermoresponsive (meth)acrylamide polymers with pendant cyclic acetal moieties
Huang, X., Du, F., Zhang, B., Zhao, J., & Li, Z. (2008) · Journal of Polymer Science Part A Polymer Chemistry · doi:10.1002/pola.22751 · Cited by 28
Harmon, A. M., Lash, M. H., Sparks, S. M., & Uhrich, K. E. (2011) · Journal of Controlled Release · doi:10.1016/j.jconrel.2011.04.004 · Cited by 28
Smart Synthetic Polymer Nanocarriers for Controlled and Site-Specific Drug Delivery
Balaure, P. C., & Grumezescu, A. M. (2015) · Current Topics in Medicinal Chemistry · doi:10.2174/1568026615666150414115852 · Cited by 30
Lactic acid‐ and carbonate‐based crosslinked polymeric micelles for drug delivery
Danquah, M. K., Fujiwara, T., & Mahato, R. I. (2012) · Journal of Polymer Science Part A Polymer Chemistry · doi:10.1002/pola.26392 · Cited by 28
Nano- and Microformulations to Advance Therapies for Visceral Leishmaniasis
Varma, D. M., Redding, E. A., Bachelder, E. M., & Ainslie, K. M. (2020) · ACS Biomaterials Science & Engineering · doi:10.1021/acsbiomaterials.0c01132 · Cited by 27
Li, L., Jiang, X., & Zhuo, R. (2009) · Journal of Polymer Science Part A Polymer Chemistry · doi:10.1002/pola.23642 · Cited by 27
Li, R., Yang, M., Li, X., Qian, X., Shen, Z., Ding, Y., & Yu, L. (2007) · Journal of Pharmaceutical Sciences · doi:10.1002/jps.21194 · Cited by 26
Zhang, G., & Jiang, X. (2019) · Polymers · doi:10.3390/polym11020316 · Cited by 26
Deng, B., Xia, M., Jin, Q. Y., Li, R., Li, L., Shen, J., Li, G., & Xie, Y. (2017) · Molecular Pharmaceutics · doi:10.1021/acs.molpharmaceut.7b00025 · Cited by 25
Mao, J. Y., Qiu, L., Ge, L., Zhou, J., Ji, Q., Yang, Y., Long, M., Wang, D., Teng, L., & Chen, J. (2020) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2020.111108 · Cited by 27
Salehi, R., Nowruzi, K., Salehi, S., Khandaghi, A. A., Davaran, S., & Entezami, A. A. (2013) · International Journal of Polymeric Materials · doi:10.1080/00914037.2013.769227 · Cited by 24
Pharmaceutical Micelles: Combining Longevity, Stability, and Stimuli Sensitivity
Carstens, M. G., Rijcken, C. J. F., van Nostrum, C. F., & Hennink, W. E. (2008) · Fundamental biomedical technologies · doi:10.1007/978-0-387-76554-9_9 · Cited by 26
Ma, Y., Jiang, X., & Zhuo, R. (2013) · Journal of Polymer Science Part A Polymer Chemistry · doi:10.1002/pola.26794 · Cited by 23
Kasmi, S., Louage, B., Nuhn, L., Driessche, A. V., Deun, J. V., Karalić, I., Risseeuw, M., Calenbergh, S. V., Hoogenboom, R., Rycke, R. M. D., et al. (2015) · Biomacromolecules · doi:10.1021/acs.biomac.5b01252 · Cited by 23
Innovative strategies for effective paclitaxel delivery: Recent developments and prospects
Wileński, S., Koper, A., Śledzińska, P., Bebyn, M. G., & Koper, K. (2024) · Journal of Oncology Pharmacy Practice · doi:10.1177/10781552231208978 · Cited by 23
Span, K., Verhoef, J. J. F., Hunt, H., van Nostrum, C. F., Brinks, V., Schellekens, H., & Hennink, W. E. (2016) · European Journal of Pharmaceutics and Biopharmaceutics · doi:10.1016/j.ejpb.2016.09.002 · Cited by 26
Yin, J., Li, Z., Yang, T., Wang, J., Zhang, X., & Zhang, Q. (2010) · Journal of drug targeting · doi:10.3109/10611861003663531 · Cited by 22
Park, C. W., Lee, S. J., Kim, D., Lee, D. S., & Kim, S. C. (2008) · Journal of Polymer Science Part A Polymer Chemistry · doi:10.1002/pola.22507 · Cited by 22
Zhang, Y., Huang, Y., Zhao, W., Lu, J., Zhang, P., Zhang, X., Li, J., Gao, X., Venkataramanan, R., & Li, S. (2014) · The AAPS Journal · doi:10.1208/s12248-014-9651-2 · Cited by 21
Sun, X., Liu, X., Li, C., Wang, Y., Liu, L., Su, F., & Li, S. (2017) · Journal of Applied Polymer Science · doi:10.1002/app.45732 · Cited by 21
Unique roles of nanotechnology in medicine and cancer-II
Alam, F., Naim, M. R., Aziz, M. H., & YADAV, N. K. (2015) · Indian Journal of Cancer · doi:10.4103/0019-509x.175591 · Cited by 21
Suresh, A., Ravilla, J., Janakiraman, N., & Sundaram, G. M. (2025) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2025.146991 · Cited by 24
Photodegradable poly(ester amide)s for indirect light-triggered release of paclitaxel
Soleimani, A., Borecki, A., & Gillies, E. R. (2014) · Polymer Chemistry · doi:10.1039/c4py00996g · Cited by 20
Ford, R. C., Brunkan-LaMontagne, A. L., Collins, R. F., Clarke, B. R., Harris, R., Naismith, J. H., & Whitfield, C. (2009) · Journal of Structural Biology · doi:10.1016/j.jsb.2009.02.005 · Cited by 20
A micellar prodrug of paclitaxel conjugated to cyclotriphosphazene
Jun, Y. J., Min, J. H., Ji, D. E., Yoo, J. H., Kim, J. H., Lee, H. J., Jeong, B., & Sohn, Y. S. (2008) · Bioorganic & Medicinal Chemistry Letters · doi:10.1016/j.bmcl.2008.10.077 · Cited by 19
Adısanoğlu, P., & Özgüney, I. (2024) · Gels · doi:10.3390/gels10040267 · Cited by 19
Metadata
- Authors
- Soga, O., van Nostrum, C. F., Fens, M., Rijcken, C. J. F., Schiffelers, R. M., Storm, G., & Hennink, W. E.
- Affiliations
- Utrecht University (NL)
- Corresponding author
- Hennink, Wim E.
- Venue
- Journal of Controlled Release
- Publisher
- Elsevier BV
- Published
- 2005-03
- Volume
- 103
- Issue
- 2
- Pages
- 341-353
- ISSN
- 0168-3659 (ISSN-L)
- OpenAlex
- W2024862077
- Cited by
- 319
- References
- 50
- Citations by year
- 2026: 2 · 2025: 10 · 2024: 7 · 2023: 7 · 2022: 2 · 2021: 7 · 2020: 13 · 2019: 13 · 2018: 11 · 2017: 17 · 2016: 21 · 2015: 23 · 2014: 15 · 2013: 23 · 2012: 21
- FWCI
- 9.70
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Controlled Release (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Advanced Drug Delivery Systems
- Physical Sciences › Materials Science › Polymers and Plastics › Dendrimers and Hyperbranched Polymers
- Keywords
- paclitaxel, polymeric micelles, thermosensitive block copolymers, polyethylene glycol, biodegradable micelles, drug delivery, controlled release, micelle stability, cytotoxicity, B16F10 melanoma cells
- MeSH terms
- Animals, Antineoplastic Agents, Phytogenic, Biocompatible Materials, Cell Survival, Drug Carriers, Drug Compounding, Drug Stability, Micelles, Particle Size, Polyethylene Glycols, Polymethacrylic Acids, Solubility, Temperature, Paclitaxel, Lactic Acid, Cell Line, Tumor, Mice
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
