Polymeric micelles—A new generation of colloidal drug carriers

Jones, Marie-Christine; Leroux, Jean-Christophe

doi:10.1016/s0939-6411(99)00039-9

Cited by 1,256Nanoparticle-Based Drug DeliverySurfactants and Colloidal SystemsAdvanced Drug Delivery Systems

Polymeric micelles—A new generation of colloidal drug carriers

Jones, Marie-Christine, Leroux, Jean-Christophe·1999·European Journal of Pharmaceutics and Biopharmaceutics

DOI 10.1016/s0939-6411(99)00039-9

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Abstract

Polymeric micelles have recently emerged as a novel promising colloidal carrier for the targeting of poorly water soluble and amphiphilic drugs. Polymeric micelles are considerably more stable than surfactant micelles and can solubilize substantial amounts of hydrophobic compounds in their inner core. Due to their hydrophilic shell and small size they sometimes exhibit prolonged circulation times in vivo and can accumulate in tumoral tissues. This review examines the chemical nature of polymeric micelles as well as the methods used to characterize them with regard to drug delivery. Special emphasis is put on the determination of critical micelle concentration and on drug loading procedures. Potential medical applications, especially in cancer chemotherapy, are described and discussed.

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Nanomicelles compared to conventional micelles are more thermodynamically stable in physiological solutions, indicated by a lower critical micellar concentration (CMC).
“Moreover, nanomicelles compared to conventional micelles are more thermodynamically stable in physiological solutions. This stability is indicated by the lower critical micellar concentration (CMC), which is essential for the stability and slow dissociation in vivo microenvironment [9].”
From Recent Advances in Nanomicelles Delivery Systems. (2020) · cites this paper as [9]
Self-assembled micelles can have various structures such as spheres, cylinders, lamellar, and vesicles based on the characteristics of the medium, length of chain, and temperature.
“Self-assembled micelles can have various structures such as a sphere, cylinders, lamellar, and vesicles based on the characteristics of the medium, length of chain, and temperature (Figure 2) [9,34,35].”
From Recent Advances in Nanomicelles Delivery Systems. (2020) · cites this paper as [9]

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Taillefer (2000) · doi:10.1002/(sici)1520-6017(200001)89:1
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Authors: Jones, M.-C., & Leroux, J.-C.
Affiliations: Université de Montréal (CA)
Corresponding author: Leroux, Jean-Christophe
ORCID: Jones, Marie-Christine
Leroux, Jean-Christophe
Venue: European Journal of Pharmaceutics and Biopharmaceutics
Publisher: Elsevier BV
Published: 1999-09
Volume: 48
Issue: 2
Pages: 101-111
ISSN: 0939-6411 (ISSN-L)
DOI: 10.1016/s0939-6411(99)00039-9
OpenAlex: W2120377744
Cited by: 1,256
References: 101
Citations by year: 2026: 13 · 2025: 25 · 2024: 35 · 2023: 40 · 2022: 45 · 2021: 51 · 2020: 66 · 2019: 58 · 2018: 59 · 2017: 70 · 2016: 68 · 2015: 57 · 2014: 72 · 2013: 70 · 2012: 71
FWCI: 2.07
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: European Journal of Pharmaceutics and Biopharmaceutics (publishedVersion)
PubMed (publishedVersion)
University of Birmingham Research Portal (University of Birmingham) (submittedVersion)
Topics: Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
Physical Sciences › Chemistry › Organic Chemistry › Surfactants and Colloidal Systems
Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Advanced Drug Delivery Systems
Keywords: polymeric micelles, colloidal drug carriers, poorly water-soluble drugs, amphiphilic drugs, drug solubilization, critical micelle concentration, drug loading, tumor targeting, circulation time, cancer chemotherapy, micelle characterization
MeSH terms: Animals, Antineoplastic Agents, Chemistry, Pharmaceutical, Colloids, Drug Carriers, Humans, Micelles, Polymers

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Polymeric micelles—A new generation of colloidal drug carriers

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