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Controlled delivery of VEGF via modulation of alginate microparticle ionic crosslinking
Open accessAbstract
Clinical application of therapeutic angiogenesis is hampered by a lack of viable systems that demonstrate controlled, sustained release of vascular endothelial growth factor (VEGF). Alginate has emerged as a popular material for VEGF delivery; however most alginate-based systems offer limited means to control the rate of VEGF release beyond reducing the VEGF:alginate ratio to suboptimal efficiency. This study describes methods to control the release of VEGF from small (<10 μm mean diameter) alginate microparticles via the use of different ionic crosslinkers. Crosslinking with Zn2+ versus Ca2+ reduced VEGF diffusional release and the combination of discrete populations of either Zn2+- or Ca2+-crosslinked particles allowed for control over the sustained release profiles for VEGF. The particle preparations were non-toxic and VEGF was bioactive after release. These results demonstrate that ionic modulation of alginate crosslinking is a viable strategy for controlling release of VEGF while retaining the high protein:polymer ratio that makes alginate an attractive carrier for delivery of protein therapeutics.
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Cited by
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Zhu, J., & Marchant, R. E. (2011) · Expert Review of Medical Devices · doi:10.1586/erd.11.27 · Cited by 1,430
Alginate composites for bone tissue engineering: A review
Venkatesan, J., Bhatnagar, I., Manivasagan, P., Kang, K.-H., & Kim, S.-K. (2015) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2014.07.008 · Cited by 906
Biopolymer-based microgels/nanogels for drug delivery applications
Oh, J. K., Lee, D. I., & Park, J. M. (2009) · Progress in Polymer Science · doi:10.1016/j.progpolymsci.2009.08.001 · Cited by 542
Xu, J., Chu, T., Yu, T., Li, N., Wang, C., Li, C., Zhang, Y., Meng, H., & Nie, G. (2022) · ACS Nano · doi:10.1021/acsnano.2c05558 · Cited by 265
Sarker, M., Izadifar, M., Schreyer, D., & Chen, X. (2018) · Journal of Biomaterials Science, Polymer Edition · doi:10.1080/09205063.2018.1433420 · Cited by 109
Metadata
- Authors
- Jay, S. M., & Saltzman, W. M.
- Venue
- Journal of Controlled Release
- Publisher
- Elsevier BV
- Published
- 2009-02
- Volume
- 134
- Issue
- 1
- Pages
- 26-34
- ISSN
- 0168-3659 (ISSN-L)
- OpenAlex
- W2055370215
- Cited by
- 193
- References
- 0
- FWCI
- 6.55
- Type
- journal article
- Language
- en
- Open access
- green
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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