The DOI matches its Crossref record; 11 of the 11 references it cites were found in a registry or an index.
Design properties of hydrogel tissue-engineering scaffolds
Open accessAbstract
This article summarizes the recent progress in the design and synthesis of hydrogels as tissue-engineering scaffolds. Hydrogels are attractive scaffolding materials owing to their highly swollen network structure, ability to encapsulate cells and bioactive molecules, and efficient mass transfer. Various polymers, including natural, synthetic and natural/synthetic hybrid polymers, have been used to make hydrogels via chemical or physical crosslinking. Recently, bioactive synthetic hydrogels have emerged as promising scaffolds because they can provide molecularly tailored biofunctions and adjustable mechanical properties, as well as an extracellular matrix-like microenvironment for cell growth and tissue formation. This article addresses various strategies that have been explored to design synthetic hydrogels with extracellular matrix-mimetic bioactive properties, such as cell adhesion, proteolytic degradation and growth factor-binding.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Hydrogels for tissue engineering: scaffold design variables and applications
Drury, J. L., & Mooney, D. J. (2003) · Biomaterials · doi:10.1016/s0142-9612(03)00340-5 · Cited by 5,136
Hydrogels for biomedical applications
Hoffman, A. S. (2002) · Advanced Drug Delivery Reviews · doi:10.1016/s0169-409x(01)00239-3 · Cited by 4,864
Lutolf, M. P., & Hubbell, J. A. (2005) · Nature Biotechnology · doi:10.1038/nbt1055 · Cited by 4,551
Hydrogels in Biology and Medicine: From Molecular Principles to Bionanotechnology
Peppas, N. A., Hilt, J. Z., Khademhosseini, A., & Langer, R. (2006) · Advanced Materials · doi:10.1002/adma.200501612 · Cited by 4,109
Photopolymerizable hydrogels for tissue engineering applications
Nguyen, K. T., & West, J. L. (2002) · Biomaterials · doi:10.1016/s0142-9612(02)00175-8 · Cited by 1,669
Three-Dimensional Cell Culture Matrices: State of the Art
Lee, J., Cuddihy, M. J., & Kotov, N. A. (2008) · Tissue Engineering Part B: Reviews · doi:10.1089/teb.2007.0150 · Cited by 1,047
Physicochemical Foundations and Structural Design of Hydrogels in Medicine and Biology
Peppas, N. A., Huang, Y., Torres-Lugo, M., Ward, J. H., & Zhang, J. (2000) · Annual Review of Biomedical Engineering · doi:10.1146/annurev.bioeng.2.1.9 · Cited by 1,016
Repair of bone defects using synthetic mimetics of collagenous extracellular matrices
Lutolf, M. P., Weber, F. E., Schmoekel, H. G., Schense, J. C., Kohler, T., Müller, R., & Hubbell, J. A. (2003) · Nature Biotechnology · doi:10.1038/nbt818 · Cited by 850
Prabaharan, M., & Mano, J. F. (2006) · Macromolecular Bioscience · doi:10.1002/mabi.200600164 · Cited by 347
Galler, K. M., Aulisa, L., Regan, K. R., D’Souza, R. N., & Hartgerink, J. D. (2010) · Journal of the American Chemical Society · doi:10.1021/ja910481t · Cited by 339
Cited by
3D bioprinting for engineering complex tissues
Mandrycky, C., Wang, Z., Kim, K., & Kim, D.-H. (2016) · Biotechnology Advances · doi:10.1016/j.biotechadv.2015.12.011 · Cited by 1,754
The bioink: A comprehensive review on bioprintable materials
Hospodiuk, M., Dey, M., Sosnoski, D., & Ozbolat, I. T. (2017) · Biotechnology Advances · doi:10.1016/j.biotechadv.2016.12.006 · Cited by 1,118
A Comparative Review of Natural and Synthetic Biopolymer Composite Scaffolds
Reddy, M. S. B., Ponnamma, D., Choudhary, R., & Sadasivuni, K. K. (2021) · Polymers · doi:10.3390/polym13071105 · Cited by 1,104
3D Printing of Scaffolds for Tissue Regeneration Applications
Do, A., Khorsand, B., Geary, S. M., & Salem, A. K. (2015) · Advanced Healthcare Materials · doi:10.1002/adhm.201500168 · Cited by 949
El-Husseiny, H. M., Mady, E. A., Hamabe, L., Abugomaa, A., Shimada, K., Yoshida, T., Tanaka, T., Yokoi, A., Elbadawy, M., & Tanaka, R. (2022) · Materials Today Bio · doi:10.1016/j.mtbio.2021.100186 · Cited by 533
Metadata
- Authors
- Zhu, J., & Marchant, R. E.
- Venue
- Expert Review of Medical Devices
- Publisher
- Informa UK Limited
- Published
- 2011-09
- Volume
- 8
- Issue
- 5
- Pages
- 607-626
- ISSN
- 1743-4440 (ISSN-L)
- 1745-2422
- OpenAlex
- W2153320120
- Cited by
- 1,430
- References
- 11
- FWCI
- 10.39
- Type
- journal article
- Language
- en
- Open access
- green
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Design properties of hydrogel tissue-engineering scaffolds. https://app.cochat.ai/papers/10.1586/erd.11.27
- The paper
- Zhu, J., & Marchant, R. E. (2011). Design properties of hydrogel tissue-engineering scaffolds. Expert Review of Medical Devices. https://doi.org/10.1586/erd.11.27
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
