The DOI matches its Crossref record; 29 of the 29 references it cites were found in a registry or an index.
Effective GDNF brain delivery using microspheres—A promising strategy for Parkinson's disease
Open accessAbstract
Glial cell line-derived neurotrophic factor (GDNF) has shown promise in the treatment of neurodegenerative disorders of basal ganglia origin such us Parkinson's disease (PD). In this study, we investigated the neurorestorative effect of controlled GDNF delivery using biodegradable microspheres in an animal model with partial dopaminergic lesion. Microspheres were loaded with N-glycosylated recombinant GDNF and prepared using the Total Recirculation One-Machine System (TROMS). GDNF-loaded microparticles were unilaterally injected into the rat striatum by stereotaxic surgery two weeks after a unilateral partial 6-OHDA nigrostriatal lesion. Animals were tested for amphetamine-induced rotational asymmetry at different times and were sacrificed two months after microsphere implantation for immunohistochemical analysis. The putative presence of serum IgG antibodies against rat glycosylated GDNF was analyzed for addressing safety issues. The results demonstrated that GDNF-loaded microspheres, improved the rotational behavior induced by amphetamine of the GDNF-treated animals together with an increase in the density of TH positive fibers at the striatal level. The developed GDNF-loaded microparticles proved to be suitable to release biologically active GDNF over up to 5 weeks in vivo. Furthermore, none of the animals developed antibodies against GDNF demonstrating the safety of glycosylated GDNF use.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“Apart from this GDNF-loaded microsphere increase in TH-positive fibers in the striatum and substantia nigra, the results suggested neuroprotection and neurorestoration activity.129,130”
From Targeted therapy in chronic diseases using nanomaterial-based drug delivery vehicles (2019) · cites this paper as [130]
In the citing paper
“Similar results were also observed by Garbayo et al., where PLGA-MS-mediated GDNF release demonstrated antiparkinsonian effects, as confirmed by the improvement in the amphetamine-induced rotational behavior test.130”
From Targeted therapy in chronic diseases using nanomaterial-based drug delivery vehicles (2019) · cites this paper as [130]
Citations
Cites
The rat brain in stereotaxic coordinates
Palkovits, M. (1983) · Neuropeptides · doi:10.1016/0143-4179(83)90049-5 · Cited by 28,959
The Rat Brain in Stereotaxic Coordinates
Paxinos, G., & Watson, C. (1983) · Elsevier eBooks · doi:10.1016/c2009-0-63235-9 · Cited by 28,585
GDNF: a Glial Cell Line-Derived Neurotrophic Factor for Midbrain Dopaminergic Neurons
Lin, L.-F. H., Doherty, D. H., Lile, J. D., Bektesh, S. L., & Collins, F. (1993) · Science · doi:10.1126/science.8493557 · Cited by 3,206
Direct brain infusion of glial cell line–derived neurotrophic factor in Parkinson disease
Gill, S. S., Patel, N. K., Hotton, G. R., O'Sullivan, K., McCarter, R., Bunnage, M., Brooks, D. J., Svendsen, C. N., & Heywood, P. (2003) · Nature Medicine · doi:10.1038/nm850 · Cited by 1,290
Kordower, J. H., Emborg, M. E., Bloch, J., Ma, S. Y., Chu, Y., Leventhal, L., McBride, J. L., Chen, E., Palfi, S., Roitberg, B. Z., et al. (2000) · Science · doi:10.1126/science.290.5492.767 · Cited by 1,251
Lang, A. E., Gill, S., Patel, N., Lozano, A., Nutt, J. G., Penn, R., Brooks, D. J., Hotton, G. R., Moro, E., Heywood, P., et al. (2006) · Annals of Neurology · doi:10.1002/ana.20737 · Cited by 987
Kirik, D., Rosenblad, C., & Björklund, A. (1998) · Experimental Neurology · doi:10.1006/exnr.1998.6848 · Cited by 663
Slevin, J. T., Gerhardt, G. A., Smith, C. D., Gash, D. M., Kryscio, R. J., & Young, B. A. (2005) · Journal of neurosurgery · doi:10.3171/jns.2005.102.2.0216 · Cited by 474
Patel, N. K., Bunnage, M., Plaha, P., Svendsen, C. N., Heywood, P. G., & Gill, S. S. (2005) · Annals of Neurology · doi:10.1002/ana.20374 · Cited by 384
Biocompatibility of implantable synthetic polymeric drug carriers: focus on brain biocompatibility
Fournier, E., Passirani, C., Montero‐Menei, C. N., & Benoît, J. (2003) · Biomaterials · doi:10.1016/s0142-9612(03)00161-3 · Cited by 353
Self-citation
Flagged first, then by citations
Cited by
Sorted by citations
PLGA-based nanoparticles: An overview of biomedical applications
Danhier, F., Ansorena, E., Silva, J. M., Coco, R., Breton, A. L., & Véronique Préat, A. (2012) · Journal of Controlled Release · doi:10.1016/j.jconrel.2012.01.043 · Cited by 4,006
Self-citationGDNF, NGF and BDNF as Therapeutic Options for Neurodegeneration
Allen, S. J., Watson, J. J., Shoemark, D. K., Barua, N. U., & Patel, N. K. (2013) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2013.01.004 · Cited by 820
Targeted therapy in chronic diseases using nanomaterial-based drug delivery vehicles
Singh, A. P., Biswas, A., Shukla, A., & Maiti, P. (2019) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-019-0068-3 · Cited by 645
Current and Novel Polymeric Biomaterials for Neural Tissue Engineering
Boni, R., Ali, A., Shavandi, A., & Clarkson, A. N. (2018) · Journal of Biomedical Science · doi:10.1186/s12929-018-0491-8 · Cited by 439
Biomaterials for promoting brain protection, repair and regeneration
Orive, G., Anitua, E., Pedraz, J. L., & Emerich, D. F. (2009) · Nature reviews. Neuroscience · doi:10.1038/nrn2685 · Cited by 421
Stem cell technology for neurodegenerative diseases
Lunn, J. S., Sakowski, S. A., Hur, J., & Feldman, E. L. (2011) · Annals of Neurology · doi:10.1002/ana.22487 · Cited by 275
Formiga, F. R., Pelacho, B., Garbayo, E., Abizanda, G., Gavira, J. J., Simón‐Yarza, T., Mazo, M. M., Tamayo, E., Jauquicoa, C., & Ortíz-de-Solórzano, C. (2010) · Journal of Controlled Release · doi:10.1016/j.jconrel.2010.07.097 · Cited by 210
Self-citationPotential of endogenous regenerative technology for in situ regenerative medicine☆
Anitua, E., Sánchez, M., & Orive, G. (2010) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2010.01.001 · Cited by 208
Mead, B. P., Kim, N., Miller, G. W., Hodges, D., Mastorakos, P., Klibanov, A. L., Mandell, J. W., Hirsh, J., Suk, J. S., Hanes, J., et al. (2017) · Nano Letters · doi:10.1021/acs.nanolett.7b00616 · Cited by 151
Lin, C., Hsieh, H.-Y., Chen, C., Wu, S.-R., Tsai, C.-H., Huang, C.-Y., Hua, M., Wei, K., Yeh, C., & Liu, H.-L. (2016) · Journal of Controlled Release · doi:10.1016/j.jconrel.2016.05.052 · Cited by 156
Advances in Parkinson’s Disease: 200 Years Later
del Rey, N. L., Quiroga‐Varela, A., Garbayo, E., Carballo‐Carbajal, I., Fernández‐Santiago, R., Monje, M. H. G., Trigo‐Damas, I., Blanco‐Prieto, M. J., & Blesa, J. (2018) · Frontiers in Neuroanatomy · doi:10.3389/fnana.2018.00113 · Cited by 146
Self-citationAwareness and current knowledge of Parkinson’s disease: a neurodegenerative disorder
Khan, A. U., Akram, M., Daniyal, M., & Zainab, R. (2018) · International Journal of Neuroscience · doi:10.1080/00207454.2018.1486837 · Cited by 151
Intranasal Administration of TAT-Conjugated Lipid Nanocarriers Loading GDNF for Parkinson’s Disease
Hernando, S., Herrán, E., Figueiro‐Silva, J., Pedraz, J. L., Igartúa, M., Carro, E., & Hernández, R. M. (2017) · Molecular Neurobiology · doi:10.1007/s12035-017-0728-7 · Cited by 137
Nanomedicine and drug delivery systems in cancer and regenerative medicine
Garbayo, E., Pascual‐Gil, S., Rodríguez‐Nogales, C., Saludas, L., de Mendoza, A. E., & Blanco‐Prieto, M. J. (2020) · Wiley Interdisciplinary Reviews Nanomedicine and Nanobiotechnology · doi:10.1002/wnan.1637 · Cited by 140
Self-citationDelcroix, G. J.-R., Garbayo, E., Sindji, L., Thomas, O., Vanpouille‐Box, C., Schiller, P. C., & Montero‐Menei, C. N. (2010) · Biomaterials · doi:10.1016/j.biomaterials.2010.10.041 · Cited by 127
Self-citationRepairing the parkinsonian brain with neurotrophic factors
Aron, L., & Klein, R. (2010) · Trends in Neurosciences · doi:10.1016/j.tins.2010.11.001 · Cited by 127
Géral, C., Angelova, A., & Lesieur, S. (2013) · Pharmaceutics · doi:10.3390/pharmaceutics5010127 · Cited by 126
Ansorena, E., Berdt, P. D., Učakar, B., Simón‐Yarza, T., Jacobs, D., Schakman, O., Jankovski, A., Deumens, R., Blanco‐Prieto, M. J., Véronique Préat, A., et al. (2013) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2013.07.045 · Cited by 109
Self-citationCheca-Casalengua, P., Jiang, C., Bravo‐Osuna, I., Tucker, B. A., Molina-Martínez, I. T., Young, M. J., & Herrero‐Vanrell, R. (2011) · Journal of Controlled Release · doi:10.1016/j.jconrel.2011.06.023 · Cited by 106
Biomaterial-based drug delivery systems for the controlled release of neurotrophic factors
Mohtaram, N. K., Montgomery, A., & Willerth, S. M. (2013) · Biomedical Materials · doi:10.1088/1748-6041/8/2/022001 · Cited by 104
Cell and biomolecule delivery for tissue repair and regeneration in the central nervous system
Donaghue, I. E., Tam, R. Y., Sefton, M. V., & Shoichet, M. S. (2014) · Journal of Controlled Release · doi:10.1016/j.jconrel.2014.05.040 · Cited by 102
de Tassigny, X. D., Pascual, A., & López‐Barneo, J. (2015) · Frontiers in Neuroanatomy · doi:10.3389/fnana.2015.00010 · Cited by 99
The therapeutic potential of IGF-I in skeletal muscle repair
Song, Y., Song, J. L., Delafontaine, P., & Godard, M. P. (2013) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2013.03.004 · Cited by 102
Lampe, K. J., Kern, D. S., Mahoney, M. J., & Bjugstad, K. B. (2011) · Journal of Biomedical Materials Research Part A · doi:10.1002/jbm.a.33011 · Cited by 102
Esteves, M., Cristóvão, A. C., Saraiva, T., Rocha, S. M., Baltazar, G., Ferreira, L., & Bernardino, L. (2015) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2015.00020 · Cited by 88
Drug development in Parkinson's disease: From emerging molecules to innovative drug delivery systems
Garbayo, E., Ansorena, E., & Blanco‐Prieto, M. J. (2013) · Maturitas · doi:10.1016/j.maturitas.2013.05.019 · Cited by 83
Self-citationNewland, B., Welzel, P. B., Newland, H., Renneberg, C., Kolar, P., Tsurkan, M. V., Rosser, A., Freudenberg, U., & Werner, C. (2015) · Small · doi:10.1002/smll.201500898 · Cited by 83
Drug Delivery Systems for Imaging and Therapy of Parkinson';s Disease
Silindir‐Gunay, M., Özer, A. Y., & Chalon, S. (2015) · Current Neuropharmacology · doi:10.2174/1570159x14666151230124904 · Cited by 83
Glavaski‐Joksimovic, A., Virág, T., Mangatu, T. A., McGrogan, M. P., Wang, X. S., & Bohn, M. C. (2010) · Journal of Neuroscience Research · doi:10.1002/jnr.22435 · Cited by 77
Mignani, S. M., Bryszewska, M. J., Zabłocka, M., Klajnert‐Maculewicz, B., Cladera, J., Shcharbin, D., & Majoral, J. (2016) · Progress in Polymer Science · doi:10.1016/j.progpolymsci.2016.09.006 · Cited by 77
Delivery of Alginate Scaffold Releasing Two Trophic Factors for Spinal Cord Injury Repair
Grulova, I., Slovinská, L., Blaško, J., Devaux, S., Wisztorski, M., Salzet, M., Fournier, I., Kryukov, O., Cohen, S., & Čı́žková, D. (2015) · Scientific Reports · doi:10.1038/srep13702 · Cited by 77
Herrán, E., Ruíz-Ortega, J. Á., Aristieta, A., Igartúa, M., Requejo, C., Lafuente, J. V., Ugedo, L., Pedraz, J. L., & Hernández, R. M. (2013) · European Journal of Pharmaceutics and Biopharmaceutics · doi:10.1016/j.ejpb.2013.03.034 · Cited by 68
PEGylated-PLGA microparticles containing VEGF for long term drug delivery
Simón‐Yarza, T., Formiga, F. R., Tamayo, E., Pelacho, B., Prósper, F., & Blanco‐Prieto, M. J. (2012) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2012.07.006 · Cited by 66
Self-citationNanoparticle-mediated growth factor delivery systems: A new way to treat Alzheimer's disease
Lauzon, M.-A., Daviau, A., Marcos, B., & Faucheux, N. (2015) · Journal of Controlled Release · doi:10.1016/j.jconrel.2015.03.024 · Cited by 66
Garbayo, E., Ansorena, E., Lana, H., Carmona‐Abellán, M., Marcilla, I., Lanciego, J. L., Luquín, M. R., & Blanco‐Prieto, M. J. (2016) · Biomaterials · doi:10.1016/j.biomaterials.2016.09.015 · Cited by 65
Self-citationCollagen for brain repair: therapeutic perspectives
Humpel, C., & Uçar, B. (2018) · Neural Regeneration Research · doi:10.4103/1673-5374.230273 · Cited by 65
A novel polymeric drug delivery system for localized and sustained release of tacrolimus (FK506)
Tajdaran, K., Shoichet, M. S., Gordon, T., & Borschel, G. H. (2015) · Biotechnology and Bioengineering · doi:10.1002/bit.25598 · Cited by 64
Hernández, R. M., Herrán, E., Requejo, C., Ruíz-Ortega, J. Á., Aristieta, A., Igartúa, M., Bengoetxea, H., Ugedo, L., Pedraz, J. L., & Lafuente, J. V. (2014) · International Journal of Nanomedicine · doi:10.2147/ijn.s61940 · Cited by 63
Herrán, E., Pérez‐González, R., Igartúa, M., Pedraz, J. L., Carro, E., & Hernández, R. M. (2013) · Journal of Controlled Release · doi:10.1016/j.jconrel.2013.04.028 · Cited by 69
Zeng, W., Hui, H., Liu, Z., Chang, Z., Wang, M., He, B., & Hao, D. (2021) · Carbohydrate Polymers · doi:10.1016/j.carbpol.2021.117684 · Cited by 60
Wood, M. D., Gordon, T., Kim, H. S., Szynkaruk, M., Phua, P. D., Lafontaine, C., Kemp, S. W. P., Shoichet, M. S., & Borschel, G. H. (2012) · Regenerative Medicine · doi:10.2217/rme.12.105 · Cited by 59
A drug delivery hydrogel system based on activin B for Parkinson's disease
Li, J., Darabi, M.-A., Gu, J., Shi, J., Xue, J., Huang, L. H., Liu, Y., Zhang, L., Liu, N., Zhong, W., et al. (2016) · Biomaterials · doi:10.1016/j.biomaterials.2016.06.016 · Cited by 56
Injectables and Depots to Prolong Drug Action of Proteins and Peptides
Ibeanu, N., Egbu, R., Onyekuru, L., Javaheri, H., Khaw, P. T., Williams, G. R., Brocchini, S., & Awwad, S. (2020) · Pharmaceutics · doi:10.3390/pharmaceutics12100999 · Cited by 56
Brain aging and Parkinson’s disease: New therapeutic approaches using drug delivery systems
Rodríguez‐Nogales, C., Garbayo, E., Carmona‐Abellán, M., Luquín, M. R., & Blanco‐Prieto, M. J. (2015) · Maturitas · doi:10.1016/j.maturitas.2015.11.009 · Cited by 54
Self-citationNanomedicine and drug delivery: A comprehensive review of applications and challenges
Singh, K., Singhal, S., Pahwa, S., Sethi, V. A., Sharma, S., Singh, P., Kale, R. D., Ali, S. W., & Sagadevan, S. (2024) · Nano-Structures & Nano-Objects · doi:10.1016/j.nanoso.2024.101403 · Cited by 50
Advances in Nanomedicine for the Treatment of Alzheimer’s and Parkinson’s Diseases
Hernando, S., Gartziandia, O., Herrán, E., Pedraz, J. L., Igartúa, M., & Hernández, R. M. (2016) · Nanomedicine · doi:10.2217/nnm-2016-0019 · Cited by 48
Villanueva, J. R., Bravo‐Osuna, I., Herrero‐Vanrell, R., Molina-Martínez, I. T., & Guzmán, M. (2016) · European Journal of Pharmaceutical Sciences · doi:10.1016/j.ejps.2016.03.012 · Cited by 48
Garbayo, E., Ansorena, E., Lanciego, J. L., Blanco‐Prieto, M. J., & Aymerich, M. S. (2011) · Movement Disorders · doi:10.1002/mds.23793 · Cited by 47
Self-citationExploring the role of polymers to overcome ongoing challenges in the field of extracellular vesicles
Simon, L., Lapinte, V., & Morille, M. (2023) · Journal of Extracellular Vesicles · doi:10.1002/jev2.12386 · Cited by 47
The role of growth factors as a therapeutic approach to demyelinating disease
Huang, Y., & Dreyfus, C. F. (2016) · Experimental Neurology · doi:10.1016/j.expneurol.2016.02.023 · Cited by 46
Shadfar, S., Kim, Y.-G., Katila, N., Neupane, S., Ojha, U., Bhurtel, S., Srivastav, S., Jeong, G., Park, P., Hong, J. T., et al. (2016) · Molecular Neurobiology · doi:10.1007/s12035-016-0342-0 · Cited by 42
Microspheres as intraocular therapeutic tools in chronic diseases of the optic nerve and retina
Bravo‐Osuna, I., Andrés‐Guerrero, V., Arranz-Romera, A., Esteban-Pérez, S., Molina-Martínez, I. T., & Herrero‐Vanrell, R. (2018) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2018.01.007 · Cited by 42
Cohen, A. D., Zigmond, M. J., & Smith, A. D. (2010) · Brain Research · doi:10.1016/j.brainres.2010.11.006 · Cited by 40
Ergül, Z., Debuigne, A., Calvignac, B., Boury, F., & Jérôme, C. (2015) · Journal of Materials Chemistry B · doi:10.1039/c5tb00887e · Cited by 38
Newland, B., Wolff, P., Zhou, D., Wang, W., Zhang, H., Rosser, A., Wang, W., & Werner, C. (2016) · Biomaterials Science · doi:10.1039/c5bm00542f · Cited by 38
Diagnostic and Therapeutic Uses of Nanomaterials in the Brain
Garbayo, E., de Mendoza, A. E., & Blanco‐Prieto, M. J. (2014) · Current Medicinal Chemistry · doi:10.2174/0929867321666140815124246 · Cited by 38
Self-citationThe Effects of Glial Cell Line-Derived Neurotrophic Factor after Spinal Cord Injury
Rosich, K., Hanna, B. F., Ibrahim, R. K., Hellenbrand, D. J., & Hanna, A. (2017) · Journal of Neurotrauma · doi:10.1089/neu.2017.5175 · Cited by 37
An engineered biocompatible drug delivery system enhances nerve regeneration after delayed repair
Tajdaran, K., Gordon, T., Wood, M. D., Shoichet, M. S., & Borschel, G. H. (2015) · Journal of Biomedical Materials Research Part A · doi:10.1002/jbm.a.35572 · Cited by 35
Adipose-derived stem cells combined with Neuregulin-1 delivery systems for heart tissue engineering
Díaz-Herráez, P., Garbayo, E., Simón‐Yarza, T., Formiga, F. R., Prósper, F., & Blanco‐Prieto, M. J. (2013) · European Journal of Pharmaceutics and Biopharmaceutics · doi:10.1016/j.ejpb.2013.03.022 · Cited by 34
Self-citationNanotherapeutic strategies for the treatment of neurodegenerative diseases
Huang, M., Gu, X. Q., & Gao, X. (2018) · Elsevier eBooks · doi:10.1016/b978-0-12-814001-7.00013-5 · Cited by 34
Recent Strategies for Targeted Brain Drug Delivery
Ogawa, K., Kato, N., & Kawakami, S. (2020) · Chemical and Pharmaceutical Bulletin · doi:10.1248/cpb.c20-00041 · Cited by 34
Ferrini, F., Salio, C., Boggio, E. M., & Merighi, A. (2020) · Current Neuropharmacology · doi:10.2174/1570159x18666201116143422 · Cited by 34
Prospects for polymer therapeutics in Parkinson's disease and other neurodegenerative disorders
Newland, B., Newland, H., Werner, C., Rosser, A., & Wang, W. (2015) · Progress in Polymer Science · doi:10.1016/j.progpolymsci.2014.12.002 · Cited by 35
Uçar, B., Kajtez, J., Foidl, B. M., Eigel, D., Werner, C., Long, K. R., Emnéus, J., Bizeau, J., Lomora, M., Pandit, A. S., et al. (2020) · Acta Biomaterialia · doi:10.1016/j.actbio.2020.11.035 · Cited by 33
New non-oral drug delivery systems for Parkinson's disease treatment
Md, S., Haque, S., Sahni, J. K., Baboota, S., & Ali, J. (2011) · Expert Opinion on Drug Delivery · doi:10.1517/17425247.2011.556616 · Cited by 33
Wood, M. D., Gordon, T., Kemp, S. W. P., Liu, E. H., Kim, H. S., Shoichet, M. S., & Borschel, G. H. (2012) · Biotechnology and Bioengineering · doi:10.1002/bit.24800 · Cited by 32
Uçar, B., & Humpel, C. (2019) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2019.04.012 · Cited by 32
Biodegradation and heart retention of polymeric microparticles in a rat model of myocardial ischemia
Formiga, F. R., Garbayo, E., Díaz-Herráez, P., Abizanda, G., Simón‐Yarza, T., Tamayo, E., Prósper, F., & Blanco‐Prieto, M. J. (2013) · European Journal of Pharmaceutics and Biopharmaceutics · doi:10.1016/j.ejpb.2013.02.017 · Cited by 32
Self-citationTroncoso-Escudero, P., Sepúlveda, D., Pérez-Arancibia, R., Parra, A. V., Arcos, J., Grünenwald, F., & Vidal, R. L. (2020) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2020.571185 · Cited by 31
Neurotrophic Factors and Neurodegenerative Diseases
Ruozi, B., Belletti, D., Bondioli, L., Vita, A. D., Forni, F., Vandelli, M. A., & Tosi, G. (2012) · International review of neurobiology · doi:10.1016/b978-0-12-386986-9.00009-0 · Cited by 29
Mesa-Infante, V., Afonso‐Oramas, D., Salas-Hernández, J., Rodríguez-Núñez, J., & Barroso‐Chinea, P. (2021) · Molecular and Cellular Neuroscience · doi:10.1016/j.mcn.2021.103684 · Cited by 29
Effect of different sintering methods on bioactivity and release of proteins from PLGA microspheres
Dormer, N. H., Gupta, V., Scurto, A. M., Berkland, C. J., & Detamore, M. S. (2013) · Materials Science and Engineering C · doi:10.1016/j.msec.2013.06.026 · Cited by 28
Wu, S.-L., Li, G., Li, X., Lin, C., Yu, D., Luan, S., & Ma, C. (2014) · International Journal of Molecular Sciences · doi:10.3390/ijms15033612 · Cited by 27
Hierarchical Microplates as Drug Depots with Controlled Geometry, Rigidity, and Therapeutic Efficacy
Francesco, M. D., Primavera, R., Romanelli, D., Palomba, R., Pereira, R. C., Catelani, T., Celia, C., Marzio, L. D., Fresta, M., Mascolo, D. D., et al. (2018) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.7b19136 · Cited by 26
Villanueva, J. R., Esteban, J. M., & Villanueva, L. R. (2020) · Pharmaceutics · doi:10.3390/pharmaceutics12020094 · Cited by 26
Blood-to-Brain Drug Delivery Using Nanocarriers
Gaillard, P. J., Visser, C. C., de Boer, M., Appeldoorn, C. C. M., & Rip, J. (2013) · AAPS advances in the pharmaceutical sciences series · doi:10.1007/978-1-4614-9105-7_15 · Cited by 26
Brain Drug Delivery Systems for Neurodegenerative Disorders
Garbayo, E., Ansorena, E., & Blanco‐Prieto, M. J. (2012) · Current Pharmaceutical Biotechnology · doi:10.2174/138920112803341761 · Cited by 25
Self-citationNeurotrophins as Therapeutic Agents for Parkinson’s Disease; New Chances From Focused Ultrasound?
Stefani, A., Pierantozzi, M., Cardarelli, S., Stefani, L., Cerroni, R., Conti, M., Garasto, E., Mercuri, N. B., Marini, C., & Sucapane, P. (2022) · Frontiers in Neuroscience · doi:10.3389/fnins.2022.846681 · Cited by 23
Zeng, W., Liu, Z., Li, Y., Zhu, S., Ma, J., Li, W., & Gao, G. (2017) · Colloids and Surfaces B Biointerfaces · doi:10.1016/j.colsurfb.2017.08.052 · Cited by 23
Chermenina, M., Schouten, P., Nevalainen, N., Johansson, F., Orädd, G., & Strömberg, I. (2014) · Neuroscience · doi:10.1016/j.neuroscience.2014.04.008 · Cited by 22
Biodegradable microparticles for strictly regulating the release of neurotrophic factors
Gujral, C., Minagawa, Y., Fujimoto, K., Kitano, H., & Nakaji-Hirabayashi, T. (2013) · Journal of Controlled Release · doi:10.1016/j.jconrel.2013.03.031 · Cited by 21
Heparin-based, injectable microcarriers for controlled delivery of interleukin-13 to the brain
Schirmer, L., Hoornaert, C., Blon, D. L., Eigel, D., Neto, C., Gumbleton, M., Welzel, P. B., Rosser, A., Werner, C., Ponsaerts, P., et al. (2020) · Biomaterials Science · doi:10.1039/d0bm01249a · Cited by 23
Understanding the Potential of Genome Editing in Parkinson’s Disease
Arango, D., Bittar, A., Esmeral, N. P., Ocasión, C., Muñoz-Camargo, C., Cruz, J. C., Reyes, L. H., & Bloch, N. I. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22179241 · Cited by 24
Delgado-Minjares, K. M., Martínez‐Fong, D., Martínez-Dávila, I. A., Bañuelos, C., Gutiérrez-Castillo, M. E., Blanco-Álvarez, V. M., Cárdenas‐Aguayo, M. D. C., Luna‐Muñoz, J., Pacheco‐Herrero, M., & Soto-Rojas, L. O. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms222111702 · Cited by 20
Requejo, C., Ruíz-Ortega, J. Á., Bengoetxea, H., García-Blanco, A., Herrán, E., Aristieta, A., Igartúa, M., Ugedo, L., Pedraz, J. L., Hernández, R. M., et al. (2015) · Molecular Neurobiology · doi:10.1007/s12035-015-9234-y · Cited by 19
Agbay, A. M., Mohtaram, N. K., & Willerth, S. M. (2014) · Drug Delivery and Translational Research · doi:10.1007/s13346-013-0189-0 · Cited by 19
Li, X., Cudaback, E., BREYER, R. M., Montine, K. S., Keene, C. D., & Montine, T. J. (2012) · The FASEB Journal · doi:10.1096/fj.11-200279 · Cited by 19
Gene Therapy Strategies for the Treatment of Spinal Cord Injury
Uchida, K., Nakajima, H., Guerrero, A. R., Johnson, W. E., Masri, W. E., & Baba, H. (2014) · Therapeutic Delivery · doi:10.4155/tde.14.20 · Cited by 18
Pharmacologically active microcarriers for endothelial progenitor cell support and survival
Musilli, C., Karam, J., Paccosi, S., Muscari, C., Mugelli, A., Montero‐Menei, C. N., & Parenti, A. (2012) · European Journal of Pharmaceutics and Biopharmaceutics · doi:10.1016/j.ejpb.2012.04.014 · Cited by 18
Self-citationA microfluidic platform to study the effects of GDNF on neuronal axon entrapment
Wang, Z. Z., Wood, M. D., Mackinnon, S. E., & Sakiyama‐Elbert, S. E. (2018) · Journal of Neuroscience Methods · doi:10.1016/j.jneumeth.2018.08.002 · Cited by 18
Targeting delivery in Parkinson's disease
Newland, B., Dunnett, S. B., & Dowd, E. (2016) · Drug Discovery Today · doi:10.1016/j.drudis.2016.06.003 · Cited by 17
Kakoty, V., Sarathlal, K. C., Kaur, P., Wadhwa, P. K., Vishwas, S., Khan, F. R., Alhazmi, A. Y., Almasoudi, H. H., Gupta, G., Chellappan, D. K., et al. (2023) · Neurological Sciences · doi:10.1007/s10072-023-07253-2 · Cited by 16
Lucas, N., Legrand, R., Breton, J., Déchelotte, P., Edwards‐Lévy, F., & Fetissov, S. O. (2015) · Neuroscience · doi:10.1016/j.neuroscience.2015.01.037 · Cited by 16
Cryogel microcarriers for sustained local delivery of growth factors to the brain
Hakami, A., Narasimhan, K., Comini, G., Thiele, J., Werner, C., Dowd, E., & Newland, B. (2024) · Journal of Controlled Release · doi:10.1016/j.jconrel.2024.03.023 · Cited by 15
Lafuente, J. V., Requejo, C., Carrasco, A., & Bengoetxea, H. (2017) · International review of neurobiology · doi:10.1016/bs.irn.2017.09.003 · Cited by 14
Nanodelivery of therapeutic agents in Parkinson's disease
Lafuente, J. V., Requejo, C., & Ugedo, L. (2019) · Progress in brain research · doi:10.1016/bs.pbr.2019.03.004 · Cited by 14
Hydrogels for brain repair: application to Parkinson’s disease
Campo-Montoya, R. D., Luquín, M. R., Puerta, E., Garbayo, E., & Blanco‐Prieto, M. J. (2022) · Expert Opinion on Drug Delivery · doi:10.1080/17425247.2022.2136161 · Cited by 14
Self-citationRodríguez‐Nogales, C., Garbayo, E., Martínez-Valbuena, I., Sebastián, V., Luquín, M. R., & Blanco‐Prieto, M. J. (2016) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2016.06.044 · Cited by 14
Self-citationLu, Y., Gao, H., Zhang, M., Chen, B., & Yang, H. (2017) · Medical Science Monitor · doi:10.12659/msm.902754 · Cited by 14
In situ injectable hydrogels for spinal cord regeneration: advances from the last 10 years
Morgado, P. I., Palacios, M., & Larraı́n, J. (2019) · Biomedical Physics & Engineering Express · doi:10.1088/2057-1976/ab52e8 · Cited by 14
Metadata
- Authors
- Garbayo, E., Montero-Menei, C. N., Ansorena, E., Lanciego, J. L., Aymerich, M. S., & Blanco-Prieto, M. J.
- Affiliations
- Universidad de Navarra (ES)
- Centro de Investigación Médica Aplicada (ES)
- Venue
- Journal of Controlled Release
- Publisher
- Elsevier BV
- Published
- 2009-04
- Volume
- 135
- Issue
- 2
- Pages
- 119-126
- ISSN
- 0168-3659 (ISSN-L)
- OpenAlex
- W2075997145
- Cited by
- 150
- References
- 29
- Citations by year
- 2026: 4 · 2025: 3 · 2024: 4 · 2023: 4 · 2022: 5 · 2021: 8 · 2020: 13 · 2019: 5 · 2018: 9 · 2017: 9 · 2016: 15 · 2015: 18 · 2014: 10 · 2013: 14 · 2012: 13
- FWCI
- 3.75
- Type
- journal article
- Language
- en
- Open access
- green
- hdl.handle.net
- Licence
- Locations
- Journal of Controlled Release (publishedVersion)
- PubMed (publishedVersion)
- HAL (submittedVersion)
- Deposito Adademico Digital Universidad De Navarra (University of Navarra) (submittedVersion, other-oa)
- Topics
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Advanced Drug Delivery Systems
- Health Sciences › Medicine › Clinical Neurology › Parkinson's Disease Mechanisms and Treatments
- Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
- Keywords
- glial cell line-derived neurotrophic factor, Parkinson's disease, biodegradable microspheres, controlled drug delivery, 6-hydroxydopamine lesion, nigrostriatal degeneration, striatum, amphetamine-induced rotation, tyrosine hydroxylase, neurorestoration, immunogenicity
- MeSH terms
- Polylactic Acid-Polyglycolic Acid Copolymer, Animals, Brain, Cell Differentiation, Corpus Striatum, Disease Models, Animal, Drug Carriers, Female, Glycosylation, Immunohistochemistry, Kinetics, Microspheres, Models, Neurological, Parkinson Disease, Particle Size, Polyglycolic Acid, Recombinant Proteins, Drug Delivery Systems, PC12 Cells, Rats, Sprague-Dawley, Fluorescent Antibody Technique, Indirect, Lactic Acid, Glial Cell Line-Derived Neurotrophic Factor, Rats
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review