GDNF, NGF and BDNF as Therapeutic Options for Neurodegeneration

Allen, Shelley J.; Watson, Judy J.; Shoemark, Deborah K.; Barua, Neil U.; Patel, Nikunj K.

doi:10.1016/j.pharmthera.2013.01.004

Cited by 820Nerve injury and regenerationAlzheimer's disease research and treatmentsParkinson's Disease Mechanisms and Treatments

GDNF, NGF and BDNF as Therapeutic Options for Neurodegeneration

Allen, Shelley J., Watson, Judy J., Shoemark, Deborah K., Barua, Neil U., Patel, Nikunj K.·2013·Pharmacology & Therapeutics

DOI 10.1016/j.pharmthera.2013.01.004

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Abstract

Glial cell-derived neurotrophic factor (GDNF), and the neurotrophin nerve growth factor (NGF) and brain-derived neurotrophic factor (BDNF) are important for the survival, maintenance and regeneration of specific neuronal populations in the adult brain. Depletion of these neurotrophic factors has been linked with disease pathology and symptoms, and replacement strategies are considered as potential therapeutics for neurodegenerative diseases such as Parkinson's, Alzheimer's and Huntington's diseases. GDNF administration has recently been shown to be an effective treatment for Parkinson's disease, with clinical trials currently in progress. Trials with NGF for Alzheimer's disease are ongoing, with some degree of success. Preclinical results using BDNF also show much promise, although there are accompanying difficulties. Ultimately, the administration of a therapy involving proteins in the brain has inherent problems. Because of the blood-brain-barrier, the protein must be infused directly, produced by viral constructs, secreted from implanted protein-secreting cells or actively transported across the brain. An alternative to this is the use of a small molecule agonist, a modulator or enhancer targeting the associated receptors. We evaluate these neurotrophic factors as potential short or long-term treatments, weighing up preclinical and clinical results with the possible effects on the underlying neurodegenerative process.

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Neurotrophic factors BDNF and GDNF protect dopaminergic neurons in PD mice by preventing neuronal death.
“Neurotrophic factors, such as BDNF and GDNF, have been shown to protect dopaminergic neurons in PD mice by preventing neuronal death [31,32].”
From Neuroprotective Effects of Bifidobacterium breve CCFM1067 in MPTP-Induced Mouse Models of Parkinson’s Disease (2022) · cites this paper as [32]
Neurodegenerative and neuropsychiatric diseases may be partially caused by defects in synaptic plasticity associated with insufficient neuronal supply of BDNF and other neurotrophic factors.
“Furthermore, it was shown that neurodegenerative and neuropsychiatric diseases may be partially caused by defects in synaptic plasticity associated with the insufficient neuronal supply of BDNF and other neurotrophic factors [11,12,13].”
From BDNF as a Promising Therapeutic Agent in Parkinson’s Disease (2020) · cites this paper as [13]

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Authors: Allen, S. J., Watson, J. J., Shoemark, D. K., Barua, N. U., & Patel, N. K.
Affiliations: Frenchay Hospital (GB)
Corresponding author: Allen, Shelley J.
ORCID: Allen, Shelley J.
Shoemark, Deborah K.
Barua, Neil U.
Patel, Nikunj K.
Venue: Pharmacology & Therapeutics
Publisher: Elsevier BV
Published: 2013-05
Volume: 138
Issue: 2
Pages: 155-175
ISSN: 0163-7258 (ISSN-L)
DOI: 10.1016/j.pharmthera.2013.01.004
OpenAlex: W2006376003
Cited by: 820
References: 256
Citations by year: 2026: 42 · 2025: 68 · 2024: 80 · 2023: 74 · 2022: 64 · 2021: 68 · 2020: 49 · 2019: 56 · 2018: 66 · 2017: 53 · 2016: 71 · 2015: 48 · 2014: 63 · 2013: 17
FWCI: 6.77
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
Locations: Pharmacology & Therapeutics (publishedVersion)
PubMed (publishedVersion)
Explore Bristol Research (submittedVersion)
Bristol Research (University of Bristol) (submittedVersion)
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Nerve injury and regeneration
Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
Health Sciences › Medicine › Neurology › Parkinson's Disease Mechanisms and Treatments
Keywords: glial cell line-derived neurotrophic factor, nerve growth factor, brain-derived neurotrophic factor, neurotrophic factors, neurodegenerative diseases, Parkinson's disease, Alzheimer's disease, Huntington's disease, blood-brain barrier, viral gene therapy, small molecule agonists, neurotrophin receptors
MeSH terms: Animals, Humans, Ligands, Models, Molecular, Nerve Growth Factors, Brain-Derived Neurotrophic Factor, Neurodegenerative Diseases, Glial Cell Line-Derived Neurotrophic Factor

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GDNF, NGF and BDNF as Therapeutic Options for Neurodegeneration

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