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Image-guided drug delivery with magnetic resonance guided high intensity focused ultrasound and temperature sensitive liposomes in a rabbit Vx2 tumor model
Open accessAbstract
Clinical-grade doxorubicin encapsulated low temperature sensitive liposomes (LTSLs) were combined with a clinical magnetic resonance-guided high intensity focused ultrasound (MR-HIFU) platform to investigate in vivo image-guided drug delivery. Plasma pharmacokinetics were determined in 3 rabbits. Fifteen rabbits with Vx2 tumors within superficial thigh muscle were randomly assigned into three treatment groups: 1) free doxorubicin, 2) LTSL and 3) LTSL + MR-HIFU. For the LTSL + MR-HIFU group, mild hyperthermia (40-41 °C) was applied to the tumors using an MR-HIFU system. Image-guided non-invasive hyperthermia was applied for a total of 30 min, completed within 1h after LTSL infusion. High-pressure liquid chromatography (HPLC) analysis of the harvested tumor and organ/tissue homogenates was performed to determine doxorubicin concentration. Fluorescence microscopy was performed to determine doxorubicin spatial distribution in the tumors. Sonication of Vx2 tumors resulted in accurate (mean = 40.5 ± 0.1 °C) and spatially homogenous (SD = 1.0 °C) temperature control in the target region. LTSL + MR-HIFU resulted in significantly higher tumor doxorubicin concentrations (7.6- and 3.4-fold greater compared to free doxorubicin and LTSL respectively, p<0.05, Newman-Keuls). This improved tumor concentration was achieved despite heating <25% of the tumor volume. Free doxorubicin and LTSL treatments appeared to deliver more drug in the tumor periphery as compared to the tumor core. In contrast, LTSL + MR-HIFU treatment suggested an improved distribution with doxorubicin found in both the tumor periphery and core. Doxorubicin bio-distribution in non-tumor organs/tissues was fairly similar between treatment groups. This technique has potential for clinical translation as an image-guided method to deliver drug to a solid tumor.
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“Some auxiliary means, such as topical hyperthermia, radiotherapy and high intensity focused ultrasound, etc., can also be used to enhance this effect [158–160].”
From Non-viral delivery systems for CRISPR/Cas9-based genome editing: challenges and opportunities (2018) · cites this paper as [160]
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Citations
Cites
Drug Delivery Systems: Entering the Mainstream
Allen, T. M., & Cullis, P. R. (2004) · Science · doi:10.1126/science.1095833 · Cited by 4,552
Delivering nanomedicine to solid tumors
Jain, R. K., & Stylianopoulos, T. (2010) · Nature Reviews Clinical Oncology · doi:10.1038/nrclinonc.2010.139 · Cited by 3,265
Targeted drug delivery to tumors: Myths, reality and possibility
Bae, Y. H., & Park, K. (2011) · Journal of Controlled Release · doi:10.1016/j.jconrel.2011.06.001 · Cited by 2,000
O’Brien, M. E. R., Wigler, N., Inbar, M., Rosso, R., Grischke, E., Santoro, A., Catane, R., Kieback, D., Tomczak, P., Ackland, S. P., et al. (2004) · Annals of Oncology · doi:10.1093/annonc/mdh097 · Cited by 1,739
Pharmacokinetics of Pegylated Liposomal Doxorubicin
Gabizón, A., Shmeeda, H., & Barenholz, Y. (2003) · Clinical Pharmacokinetics · doi:10.2165/00003088-200342050-00002 · Cited by 1,639
Optimizing Liposomes for Delivery of Chemotherapeutic Agents to Solid Tumors
Drummond, D. C., Meyer, O., Hong, K., Kirpotin, D. B., & Papahadjopoulos, D. (1999) · Pharmacological Reviews · doi:10.1016/s0031-6997(24)01426-1 · Cited by 1,294
A precise and fast temperature mapping using water proton chemical shift
Ishihara, Y., Calderon, A., Watanabe, H., Okamoto, K., Suzuki, Y., Kuroda, K., & Suzuki, Y. (1995) · Magnetic Resonance in Medicine · doi:10.1002/mrm.1910340606 · Cited by 1,027
Design of Liposomes for Enhanced Local Release of Drugs by Hyperthermia
Yatvin, M. B., Weinstein, J. N., Dennis, W. H., & Blumenthal, R. P. (1978) · Science · doi:10.1126/science.364652 · Cited by 959
Lammers, T., Aime, S., Hennink, W. E., Storm, G., & Kiessling, F. M. (2011) · Accounts of Chemical Research · doi:10.1021/ar200019c · Cited by 906
Ultrasound–biophysics mechanisms
O’Brien, W. D. (2006) · Progress in Biophysics and Molecular Biology · doi:10.1016/j.pbiomolbio.2006.07.010 · Cited by 748
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Gray, M. D., Spiers, L., & Coussios, C. C. (2023) · Medical Physics · doi:10.1002/mp.16622 · Cited by 10
Cheng, B., Bing, C., Staruch, R., Shaikh, S., Staruch, M. W., Szczepanski, D., Williams, N. S., Laetsch, T. W., & Chopra, R. (2020) · International Journal of Hyperthermia · doi:10.1080/02656736.2020.1812737 · Cited by 10
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Tydings, C., & Kim, A. (2019) · Current Opinion in Pediatrics · doi:10.1097/mop.0000000000000865 · Cited by 8
“6-fold greater tumor doxorubicin concentration compared with free doxorubicin [55].”
BackgroundOpportunities in ultrasonic drug delivery to tumor
Raikwar, S., Saraf, S., Panda, P. K., Tiwari, A., Bidla, P. D., Verma, A., Jain, A., & Jain, S. (2021) · Elsevier eBooks · doi:10.1016/b978-0-12-820043-8.00016-5 · Cited by 8
Chen, Q., Zhu, X., Chen, Q., Wang, K., & Meng, Z. (2013) · Pancreatology · doi:10.1016/j.pan.2013.10.001 · Cited by 8
Ranjan, A., Kishore, D., Ashar, H. K., Neel, T., Singh, A., & More, S. (2021) · International Journal of Hyperthermia · doi:10.1080/02656736.2021.1903582 · Cited by 8
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Fernando, R., Maples, D., Senavirathna, L. K., Zheng, Y., Polf, J., Benton, E. R., Bartels, K. E., Piao, D. D., & Ranjan, A. (2014) · Pharmaceutical Research · doi:10.1007/s11095-014-1404-5 · Cited by 7
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Motamarry, A., Wolfe, A., Ramajayam, K. K., Pattanaik, S., Benton, T. Z., Peterson, Y. K., Faridi, P., Prakash, P., Twombley, K. E., & Haemmerich, D. (2022) · Cancers · doi:10.3390/cancers14051322 · Cited by 6
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Xiong, P., Ding, A., Gong, X., Yinzhu, Z., Jia, L., Shen, G., & Yazhu, C. (2015) · Technology in Cancer Research & Treatment · doi:10.1177/1533034615580441 · Cited by 4
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Fabiilli, M. L., Phanse, R. A., Moncion, A., Fowlkes, J. B., & Franceschi, R. T. (2015) · Ultrasound in Medicine & Biology · doi:10.1016/j.ultrasmedbio.2015.11.006 · Cited by 3
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Wang, L., Che, K., Liu, Z., Huang, X., Xiang, S., Zhu, F., & Yu, Y. (2018) · Korean Journal of Physiology and Pharmacology · doi:10.4196/kjpp.2018.22.3.291 · Cited by 2
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Meng, L., Deng, Z., Niu, L., Cai, F., & Zheng, H. (2015) · Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC) · doi:10.1109/embc.2015.7319737 · Cited by 2
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Yamamoto, V. N., Morris, K., Bolanos, J. F., Kendall, L., Arya, S., Lopes, D. H. J., Nami, M., Yu, J. S., Hsieh, M. C., Schmidt, P., et al. (2024) · Springer eBooks · doi:10.1007/978-3-030-80662-0_1 · Cited by 1
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Essex, S., & Torchilin, V. P. (2013) · Advances in delivery science and technology · doi:10.1007/978-1-4614-9434-8_4 · Cited by 1
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Herceg, V., Lange, N., & Allémann, É. (2016) · Springer eBooks · doi:10.1007/978-3-319-41421-8_17
MRI-guided Focused Ultrasound Application for Targeted Drug Delivery
Farr, N. (2014) · ResearchWorks at the University of Washington (University of Washington)
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Shah, M. R., Imran, M. A., & Ullah, S. (2017) · Elsevier eBooks · doi:10.1016/b978-0-323-52729-3.00007-x
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Staruch, R., Hynynen, K., & Chopra, R. (2013) · Handbook series for mechanical engineering/Mechanical engineering handbook series · doi:10.1201/b15085-38
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Metadata
- Authors
- Ranjan, A., Jacobs, G. C., Woods, D. L., Negussie, A. H., Partanen, A., Yarmolenko, P. S., Gacchina, C. E., Sharma, K. V., Frenkel, V., Wood, B. J., & Dreher, M. R.
- Affiliations
- National Institutes of Health (US)
- Catholic University of America (US)
- Corresponding author
- Dreher, Matthew R.
- Venue
- Journal of Controlled Release
- Publisher
- Elsevier BV
- Published
- 2012-03
- Volume
- 158
- Issue
- 3
- Pages
- 487-494
- ISSN
- 0168-3659 (ISSN-L)
- PMC
- PMC3319290
- OpenAlex
- W1982194007
- Cited by
- 267
- References
- 44
- Citations by year
- 2026: 5 · 2025: 3 · 2024: 11 · 2023: 14 · 2022: 12 · 2021: 17 · 2020: 12 · 2019: 15 · 2018: 18 · 2017: 20 · 2016: 38 · 2015: 28 · 2014: 30 · 2013: 30 · 2012: 13
- FWCI
- 13.80
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Journal of Controlled Release (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- Center for Interventional Oncology in the Intramural Research Program of the National Institutes of Health
- Topics
- Physical Sciences › Engineering › Biomedical Engineering › Ultrasound and Hyperthermia Applications
- Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
- Physical Sciences › Engineering › Biomedical Engineering › Nanoplatforms for cancer theranostics
- Keywords
- image-guided drug delivery, MR-guided focused ultrasound, thermosensitive liposomes, doxorubicin, cancer hyperthermia, VX2 tumor model, plasma pharmacokinetics, drug biodistribution
- MeSH terms
- Animals, Doxorubicin, Female, Liposomes, Neoplasms, Magnetic Resonance Spectroscopy, Rabbits, Temperature, Tissue Distribution, Ultrasonography, Drug Delivery Systems, High-Intensity Focused Ultrasound Ablation
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