Drug Delivery Systems: Entering the Mainstream
Abstract
Drug delivery systems (DDS) such as lipid- or polymer-based nanoparticles can be designed to improve the pharmacological and therapeutic properties of drugs administered parenterally. Many of the early problems that hindered the clinical applications of particulate DDS have been overcome, with several DDS formulations of anticancer and antifungal drugs now approved for clinical use. Furthermore, there is considerable interest in exploiting the advantages of DDS for in vivo delivery of new drugs derived from proteomics or genomics research and for their use in ligand-targeted therapeutics.
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Free Ce6 is not able to accumulate in the tumor site because it is a small molecule and could diffuse in and out of the tumor freely, resulting in being metabolized.
“Free Ce6 is not able to accumulate in the tumor site, since it is a small molecule and could diffuse in and out of the tumor freely, resulting in being metabolized.50”
From Catalase-Integrated Hyaluronic Acid as Nanocarriers for Enhanced Photodynamic Therapy in Solid Tumor (2019) · cites this paper as [50]
Cites
Tumor vascular permeability and the EPR effect in macromolecular therapeutics: a review
Maeda, H., Wu, J., Sawa, T., Matsumura, Y., & Hori, K. (2000) · Journal of Controlled Release · doi:10.1016/s0168-3659(99)00248-5 · Cited by 6,565 · see citing works
Long-Circulating and Target-Specific Nanoparticles: Theory to Practice
Moghimi, S. M., Hunter, A. C., & Murray, J. C. (2001) · Pharmacological Reviews · doi:10.1016/s0031-6997(24)01494-7 · Cited by 3,521 · see citing works
Effect of pegylation on pharmaceuticals
Harris, J. M., & Chess, R. B. (2003) · Nature Reviews Drug Discovery · doi:10.1038/nrd1033 · Cited by 3,431 · see citing works
The dawning era of polymer therapeutics
Duncan, R. (2003) · Nature Reviews Drug Discovery · doi:10.1038/nrd1088 · Cited by 3,273 · see citing works
Openings Between Defective Endothelial Cells Explain Tumor Vessel Leakiness
Hashizume, H., Baluk, P., Morikawa, S., McLean, J. W., Thurston, G., Roberge, S., Jain, R. K., & McDonald, D. M. (2000) · The American Journal of Pathology · doi:10.1016/s0002-9440(10)65006-7 · Cited by 1,689 · see citing works
Ligand-targeted therapeutics in anticancer therapy
Allen, T. M. (2002) · Nature reviews. Cancer · doi:10.1038/nrc903 · Cited by 1,648 · see citing works
Self-citationPharmacokinetics of Pegylated Liposomal Doxorubicin
Gabizón, A., Shmeeda, H., & Barenholz, Y. (2003) · Clinical Pharmacokinetics · doi:10.2165/00003088-200342050-00002 · Cited by 1,639 · see citing works
Small-scale systems for in vivo drug delivery
LaVan, D. A., McGuire, T., & Langer, R. (2003) · Nature Biotechnology · doi:10.1038/nbt876 · Cited by 1,301 · see citing works
Nanoparticulate systems for brain delivery of drugs.
Kreuter, J. (2001) · Advanced Drug Delivery Reviews · doi:10.1016/s0169-409x(00)00122-8 · Cited by 1,107 · see citing works
Nanoparticulate systems for brain delivery of drugs
Kreuter, J. (2012) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2012.09.015 · Cited by 958 · see citing works
Transport of molecules across tumor vasculature
Jain, R. K. (1987) · Cancer and Metastasis Reviews · doi:10.1007/bf00047468 · Cited by 869 · see citing works
Vasey, P. A., Kaye, S. B., Morrison, R. A., Twelves, C. J., Wilson, P., Duncan, R., Thomson, A. H., Murray, L. S., Hilditch, T. E., Murray, T., et al. (1999) · PubMed · Cited by 689 · see citing works
Batist, G., Ramakrishnan, G., Rao, C. S., Chandrasekharan, A., Gutheil, J. C., Guthrie, T. H., Shah, P. M., Khojasteh, A., Nair, M. K., Hoelzer, K. L., et al. (2001) · Journal of Clinical Oncology · doi:10.1200/jco.2001.19.5.1444 · Cited by 669 · see citing works
Bressler, N. M. (2002) · American Journal of Ophthalmology · doi:10.1016/s0002-9394(01)01237-5 · Cited by 666 · see citing works
Brain drug delivery of small molecules using immunoliposomes
Huwyler, J., Wu, D., & Pardridge, W. M. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.24.14164 · Cited by 656 · see citing works
Olsen, E. A., Duvic, M. A., Frankel, A. E., Kim, Y. H., Martin, A., Vonderheid, E. C., Jegasothy, B. V., Wood, G. S., Gordon, M., HEALD, P. W., et al. (2001) · Journal of Clinical Oncology · doi:10.1200/jco.2001.19.2.376 · Cited by 610 · see citing works
Glantz, M., Jaeckle, K. A., Chamberlain, M. C., Phuphanich, S., Recht, L. D., Swinnen, L. J., Maria, B., LaFollette, S., Schumann, G. B., Cole, B. F., et al. (1999) · PubMed · Cited by 529 · see citing works
Water-soluble dendritic unimolecular micelles:
Liu, M., Kono, K., & Fréchet, J. M. J. (2000) · Journal of Controlled Release · doi:10.1016/s0168-3659(99)00245-x · Cited by 477 · see citing works
Uziely, B., Jeffers, S., Isacson, R., Kutsch, K., Wei‐Tsao, D. D., Yehoshua, Z., Libson, E., Muggia, F. M., & Gabizón, A. (1995) · Journal of Clinical Oncology · doi:10.1200/jco.1995.13.7.1777 · Cited by 477 · see citing works
Chemical Approaches to Triggerable Lipid Vesicles for Drug and Gene Delivery
Guo, X. D., & Szoka, F. C. (2003) · Accounts of Chemical Research · doi:10.1021/ar9703241 · Cited by 456 · see citing works
Glantz, M., LaFollette, S., Jaeckle, K. A., Shapiro, W., Swinnen, L. J., Rozental, J. R., Phuphanich, S., Rogers, L. R., Gutheil, J. C., Batchelor, T. T., et al. (1999) · Journal of Clinical Oncology · doi:10.1200/jco.1999.17.10.3110 · Cited by 402 · see citing works
Northfelt, D., Martin, F. J., Working, P. K., Volberding, P. A., Russell, J., Newman, M., Amantea, M., & Kaplan, L. D. (1996) · The Journal of Clinical Pharmacology · doi:10.1002/j.1552-4604.1996.tb04152.x · Cited by 377 · see citing works
Influence of Cholesterol on the Association of Plasma Proteins with Liposomes
Semple, S. C., Chonn, A., & Cullis, P. R. (1996) · Biochemistry · doi:10.1021/bi950414i · Cited by 291 · see citing works
Self-citationWiseman, G. A., Gordon, L. I., Multani, P. S., Witzig, T. E., SPIES, S. M., Bartlett, N. L., Schilder, R. J., Murray, J. L., Saleh, M. N., Allen, R. S., et al. (2002) · Blood · doi:10.1182/blood.v99.12.4336 · Cited by 265 · see citing works
A Dose-Ranging Study of Pegylated Interferon Alfa-2b and Ribavirin in Chronic Hepatitis C
Glue, P., Rouzier‐Panis, R., Raffanel, C., et al. (2000) · Hepatology · doi:10.1053/jhep.2000.16661 · Cited by 247 · see citing works
Fang, J. Q., Sawa, T., & Maeda, H. (2005) · Kluwer Academic Publishers eBooks · doi:10.1007/0-306-47932-x_2 · Cited by 221 · see citing works
Skin Toxic Effects of Polyethylene Glycol–Coated Liposomal Doxorubicin
Lotem, M., Hubert, A., Lyass, O., et al. (2000) · Archives of Dermatology · doi:10.1001/archderm.136.12.1475 · Cited by 221 · see citing works
Szebeni, J., Baranyi, L., Sávay, S., Milosevits, J., Bünger, R., Laverman, P., Metselaar, J. M., Storm, G., Chanan-Khan, A. A., Liebes, L., et al. (2002) · Journal of Liposome Research · doi:10.1081/lpr-120004790 · Cited by 212 · see citing works
Cullis, P. R., Hope, M. J., Bally, M. B., Madden, T. D., Mayer, L. D., & Fenske, D. B. (1997) · Biochimica et Biophysica Acta (BBA) - Reviews on Biomembranes · doi:10.1016/s0304-4157(97)00006-3 · Cited by 212 · see citing works
Self-citationBolotin, E. M., Cohen, R., Bar, L. K., Emanuel, N., Ninio, S., Barenholz, Y., & Lasiç, D. D. (1994) · Journal of Liposome Research · doi:10.3109/08982109409037057 · Cited by 207 · see citing works
Liposomal amphotericin B (AmBisome) in Mediterranean visceral leishmaniasis: a multi-centre trial
Davidson, R. N., di Martino, L., Gradoni, L., Giacchino, R., RUSSO, R., Gaeta, G. B., Pempinello, R., Scott, S., Raimondi, F., Cascio, A., et al. (1994) · QJM · doi:10.1093/oxfordjournals.qjmed.a068903 · Cited by 196 · see citing works
Netti, P. A., Roberge, S., Boucher, Y., Baxter, L. T., & Jain, R. K. (1996) · Microvascular Research · doi:10.1006/mvre.1996.0041 · Cited by 183 · see citing works
Alberts, D. S., & Garcia, D. J. (1997) · Drugs · doi:10.2165/00003495-199700544-00007 · Cited by 182 · see citing works
Selective activation of anticancer prodrugs by monoclonal antibody–enzyme conjugates
Senter, P. D., & Springer, C. J. (2001) · Advanced Drug Delivery Reviews · doi:10.1016/s0169-409x(01)00206-x · Cited by 178 · see citing works
Tardi, P. G., CHOICE, E., Masin, D., Redelmeier, T. E., Bally, M. B., & Madden, T. D. (2000) · PubMed · Cited by 160 · see citing works
Phase I and pharmacokinetic study of SPI-77, a liposomal encapsulated dosage form of cisplatin
Terwogt, J. M. M., Groenewegen, G., Pluim, D., Maliepaard, M., Tibben, M. M., Huisman, A., Huinink, W. W. T. B., Schot, M. E., Welbank, H., Voest, E. E., et al. (2002) · Cancer Chemotherapy and Pharmacology · doi:10.1007/s002800100371 · Cited by 124 · see citing works
Phase I Study of Liposomal Vincristine
Gelmon, K. A., Tolcher, A., Diab, A. R., et al. (1999) · Journal of Clinical Oncology · doi:10.1200/jco.1999.17.2.697 · Cited by 109 · see citing works
Mehvar, R. (2003) · Current Pharmaceutical Biotechnology · doi:10.2174/1389201033489685 · Cited by 104 · see citing works
Comparative in vivo studies with paclitaxel and liposome-encapsulated paclitaxel.
Cabanes, A., Briggs, K., Gokhale, P. C., Treat, J., & Rahman, A. (1998) · International Journal of Oncology · doi:10.3892/ijo.12.5.1035 · Cited by 103 · see citing works
Siena, S., Piccart, M. J., Holmes, F. A., et al. (2003) · PubMed · Cited by 101 · see citing works
Edens, H. A., Levi, B. P., Jaye, D. L., Walsh, S. V., Reaves, T. A., Turner, J. R., Nusrat, A., & Parkos, C. A. (2002) · The Journal of Immunology · doi:10.4049/jimmunol.169.1.476 · Cited by 88 · see citing works
Pastorino, F., Brignole, C., Marimpietri, D., Pagnan, G., Morando, A., Ribatti, D., Semple, S. C., Gambini, C., Allen, T. M., & Ponzoni, M. (2003) · PubMed · Cited by 78 · see citing works
Self-citationSmith, D. H., Adams, J. R., Johnston, S. R. D., et al. (2002) · Annals of Oncology · doi:10.1093/annonc/mdf275 · Cited by 77 · see citing works
Tumor-targeted gene transfer with DNA polyplexes.
Ogris, M., & Wagner, E. (2002) · Somatic Cell and Molecular Genetics · doi:10.1023/a:1022988008131 · Cited by 65 · see citing works
Schiffelers, R. M., Storm, G., & Bakker‐Woudenberg, I. A. J. M. (2001) · Pharmaceutical Research · doi:10.1023/a:1011080211226 · Cited by 60 · see citing works
Tollemar, J. G., Andersson, S., Ringdén, O. T. H., et al. (1992) · Mycoses · doi:10.1111/j.1439-0507.1992.tb00850.x · Cited by 35 · see citing works
Early Phase I/II Trials with Gemtuzumab Ozogamicin (Mylotarg®) in Acute Myeloid Leukemia
Nabhan, C., & Tallman, M. S. (2002) · Clinical Lymphoma · doi:10.3816/clm.2002.s.004 · Cited by 32 · see citing works
Seymour, L. W., Olliff, S. P., Poole, C. J., de Takats, P. G., Orme, R., Ferry, D., Maeda, H., Konno, T., & Kerr, D. J. (1998) · International Journal of Oncology · doi:10.3892/ijo.12.6.1217 · Cited by 28 · see citing works
Bory, C., Boulieu, R., Souillet, G., et al. (1991) · Advances in experimental medicine and biology · doi:10.1007/978-1-4899-2638-8_39 · Cited by 17 · see citing works
Cheson, B. D. (2001) · Journal of Clinical Oncology · doi:10.1200/jco.2001.19.19.3908 · Cited by 15 · see citing works
Myths concerning the use of cationic liposomes in vivo
Templeton, N. S. (2003) · Expert Opinion on Biological Therapy · doi:10.1517/14712598.3.1.57 · Cited by 10 · see citing works
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Liposomal drug delivery systems: From concept to clinical applications
Allen, T. M., & Cullis, P. R. (2013) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2012.09.037 · Cited by 4,839 · see citing works
Self-citationPoly(ethylene glycol) in Drug Delivery: Pros and Cons as Well as Potential Alternatives
Knop, K., Hoogenboom, R., Fischer, D., & Schubert, U. S. (2010) · Angewandte Chemie International Edition · doi:10.1002/anie.200902672 · Cited by 3,533 · see citing works
Maeda, H., Nakamura, H., & Fang, J. (2013) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2012.10.002 · Cited by 2,376 · see citing works
Tenchov, R., Bird, R., Curtze, A. E., & Zhou, Q. (2021) · ACS Nano · doi:10.1021/acsnano.1c04996 · Cited by 2,221 · see citing works
Engineered Nanoparticles for Drug Delivery in Cancer Therapy
Sun, T., Zhang, Y. S., Pang, B., Hyun, D. C., Yang, M., & Xia, Y. (2014) · Angewandte Chemie International Edition · doi:10.1002/anie.201403036 · Cited by 2,164 · see citing works
Nanomedicine: current status and future prospects
Moghimi, S. M., Hunter, A. C., & Murray, J. C. (2005) · The FASEB Journal · doi:10.1096/fj.04-2747rev · Cited by 2,029 · see citing works
New-Concept Chemotherapy by Nanoparticles of Biodegradable Polymers: Where Are We Now?
Feng, S.-S. (2006) · Nanomedicine · doi:10.2217/17435889.1.3.297 · Cited by 1,951 · see citing works
Liposomes: Structure, composition, types, and clinical applications
Nsairat, H., Khater, D., Sayed, U., Odeh, F., Al Bawab, A., & Alshaer, W. (2022) · Heliyon · doi:10.1016/j.heliyon.2022.e09394 · Cited by 1,561 · see citing works
Applications of Nanoparticles in Biology
De, M., Ghosh, P. S., & Rotello, V. M. (2008) · Advanced Materials · doi:10.1002/adma.200703183 · Cited by 1,547 · see citing works
The evolution of commercial drug delivery technologies
Vargason, A. M., Anselmo, A. C., & Mitragotri, S. (2021) · Nature Biomedical Engineering · doi:10.1038/s41551-021-00698-w · Cited by 1,361 · see citing works
Formulation of functionalized PLGA-PEG Nanoparticles for in vivo targeted drug delivery
Cheng, J., Teply, B. A., Sherifi, I., Sung, J., Luther, G., Gu, F. X., Levy-Nissenbaum, E., Radovic-Moreno, A. F., Langer, R., & Farokhzad, O. C. (2007) · Biomaterials · doi:10.1016/j.biomaterials.2006.09.047 · Cited by 1,273 · see citing works
Rapid transport of large polymeric nanoparticles in fresh undiluted human mucus
Lai, S. K., O'Hanlon, D. E., Harrold, S., Man, S. T., Wang, Y.-Y., Cone, R., & Hanes, J. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0608611104 · Cited by 1,050 · see citing works
Mundargi, R. C., Babu, V. R., Rangaswamy, V., Patel, P., & Aminabhavi, T. M. (2008) · Journal of Controlled Release · doi:10.1016/j.jconrel.2007.09.013 · Cited by 1,025 · see citing works
Kobayashi, H., Watanabe, R., & Choyke, P. L. (2014) · Theranostics · doi:10.7150/thno.7193 · Cited by 996 · see citing works
Lombardo, D., Kiselev, M. A., & Caccamo, M. T. (2019) · Journal of Nanomaterials · doi:10.1155/2019/3702518 · Cited by 864 · see citing works
Limbach, L. K., Li, Y., Grass, R. N., Brunner, T. J., Hintermann, M. A., Muller, M., Gunther, D., & Stark, W. J. (2005) · Environmental Science & Technology · doi:10.1021/es051043o · Cited by 779 · see citing works
The accelerated blood clearance (ABC) phenomenon: Clinical challenge and approaches to manage
Abu Lila, A. S., Kiwada, H., & Ishida, T. (2013) · Journal of Controlled Release · doi:10.1016/j.jconrel.2013.07.026 · Cited by 721 · see citing works
Recent advances of cocktail chemotherapy by combination drug delivery systems
Hu, Q., Sun, W., Wang, C., & Gu, Z. (2016) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2015.10.022 · Cited by 625 · see citing works
Andresen, T. L., Jensen, S. S., & Jørgensen, K. (2005) · Progress in Lipid Research · doi:10.1016/j.plipres.2004.12.001 · Cited by 580 · see citing works
Redox-responsive polymers for drug delivery: from molecular design to applications
Huo, M., Yuan, J., Tao, L., & Wei, Y. (2014) · Polym. Chem. · doi:10.1039/c3py01192e · Cited by 561 · see citing works
Delivery of Therapeutic Proteins
Pisal, D. S., Kosloski, M. P., & Balu-Iyer, S. V. (2010) · Journal of Pharmaceutical Sciences · doi:10.1002/jps.22054 · Cited by 532 · see citing works
Multifunctional polymeric micelles for delivery of drugs and siRNA
Jhaveri, A. M., & Torchilin, V. P. (2014) · Frontiers in Pharmacology · doi:10.3389/fphar.2014.00077 · Cited by 466 · see citing works
Biodegradable polymer nanoparticles that rapidly penetrate the human mucus barrier
Tang, B. C., Dawson, M., Lai, S. K., Wang, Y.-Y., Suk, J. S., Yang, M., Zeitlin, P., Boyle, M. P., Fu, J., & Hanes, J. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0905998106 · Cited by 453 · see citing works
Perspectives and opportunities for nanomedicine in the management of atherosclerosis
Lobatto, M. E., Fuster, V., Fayad, Z. A., & Mulder, W. J. M. (2011) · Nature Reviews Drug Discovery · doi:10.1038/nrd3578 · Cited by 423 · see citing works
Nanotheranostics and image-guided drug delivery: current concepts and future directions
Lammers, T., Kiessling, F., Hennink, W. E., & Storm, G. (2010) · Molecular Pharmaceutics · doi:10.1021/mp100228v · Cited by 397 · see citing works
Chen, H., Kim, S., Li, L., Wang, S., Park, K., & Cheng, J.-X. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0707046105 · Cited by 394 · see citing works
Interactive Association of Drugs Binding to Human Serum Albumin
Yang, F., Zhang, Y., & Liang, H. (2014) · International Journal of Molecular Sciences · doi:10.3390/ijms15033580 · Cited by 376 · see citing works
Catalase-Integrated Hyaluronic Acid as Nanocarriers for Enhanced Photodynamic Therapy in Solid Tumor
Phua, S. Z. F., Yang, G., Lim, W. Q., Verma, A., Chen, H., Thanabalu, T., & Zhao, Y. (2019) · ACS Nano · doi:10.1021/acsnano.9b01087 · Cited by 375 · see citing works
Kuntsche, J., Horst, J. C., & Bunjes, H. (2011) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2011.02.001 · Cited by 363 · see citing works
Tan, M. L., Choong, P. F. M., & Dass, C. R. (2010) · Peptides · doi:10.1016/j.peptides.2009.10.002 · Cited by 350 · see citing works
Role of integrated cancer nanomedicine in overcoming drug resistance
Iyer, A. K., Singh, A., Ganta, S., & Amiji, M. M. (2013) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2013.07.012 · Cited by 343 · see citing works
Ph-responsive polymer–drug conjugates: design and progress
Pang, X., Jiang, Y., Xiao, Q., Leung, A. W., Hua, H., & Xu, C. (2016) · Journal of Controlled Release · doi:10.1016/j.jconrel.2015.12.024 · Cited by 317 · see citing works
Percec, V., Leowanawat, P., Sun, H.-J., Kulikov, O., Nusbaum, C. D., Tran, T. M., Bertin, A., Wilson, D. A., Peterca, M., Zhang, S., et al. (2013) · Journal of the American Chemical Society · doi:10.1021/ja403323y · Cited by 310 · see citing works
A review of magnet systems for targeted drug delivery
Liu, Y.-L., Chen, D., Shang, P., & Yin, D.-C. (2019) · Journal of Controlled Release · doi:10.1016/j.jconrel.2019.03.031 · Cited by 298 · see citing works
Wuttke, S., Lismont, M., Escudero, A., Rungtaweevoranit, B., & Parak, W. J. (2017) · Biomaterials · doi:10.1016/j.biomaterials.2017.01.025 · Cited by 286 · see citing works
Ranjan, A., Jacobs, G. C., Woods, D. L., Negussie, A. H., Partanen, A., Yarmolenko, P. S., Gacchina, C. E., Sharma, K. V., Frenkel, V., Wood, B. J., et al. (2012) · Journal of Controlled Release · doi:10.1016/j.jconrel.2011.12.011 · Cited by 267 · see citing works
Duan, X., Chan, C., Han, W., Guo, N., Weichselbaum, R. R., & Lin, W. (2019) · Nature Communications · doi:10.1038/s41467-019-09221-x · Cited by 256 · see citing works
pH-sensitive biomaterials for drug delivery
Zhuo, S., Zhang, F., Yu, J., Zhang, X., Yang, G., & Liu, X. (2020) · Molecules · doi:10.3390/molecules25235649 · Cited by 247 · see citing works
Single-step surface functionalization of polymeric nanoparticles for targeted drug delivery
Patil, Y. B., Toti, U. S., Khdair, A., Ma, L., & Panyam, J. (2009) · Biomaterials · doi:10.1016/j.biomaterials.2008.09.056 · Cited by 242 · see citing works
Block copolymer micelles as delivery vehicles of hydrophobic drugs: Micelle–cell interactions
Savić, R., Eisenberg, A., & Maysinger, D. (2006) · Journal of Drug Targeting · doi:10.1080/10611860600874538 · Cited by 218 · see citing works
The pharmacokinetics of Toll-like receptor agonists and the impact on the immune system
Engel, A. L., Holt, G. E., & Lu, H. (2011) · Expert Review of Clinical Pharmacology · doi:10.1586/ecp.11.5 · Cited by 205 · see citing works
Lipid-based nanoparticle formulations for small molecules and RNA drugs
Ickenstein, L. M., & Garidel, P. (2019) · Expert Opinion on Drug Delivery · doi:10.1080/17425247.2019.1669558 · Cited by 193 · see citing works
Shi, C., Guo, X., Qu, Q., Tang, Z., Wang, Y., & Zhou, S. (2014) · Biomaterials · doi:10.1016/j.biomaterials.2014.06.036 · Cited by 189 · see citing works
Aptamer-guided nanomedicines for anticancer drug delivery
Alshaer, W., Hillaireau, H., & Fattal, E. (2018) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2018.09.011 · Cited by 187 · see citing works
The immune effects of naturally occurring and synthetic nanoparticles
Chang, C. (2010) · Journal of Autoimmunity · doi:10.1016/j.jaut.2009.11.009 · Cited by 180 · see citing works
Noncovalent Encapsulation Stabilities in Supramolecular Nanoassemblies
Jiwpanich, S., Ryu, J.-H., Bickerton, S., & Thayumanavan, S. (2010) · Journal of the American Chemical Society · doi:10.1021/ja105059g · Cited by 183 · see citing works
Poly(Ethylene Glycol)–Polylactide Micelles for Cancer Therapy
Wang, J., Li, S., Han, Y., Guan, J., Chung, S., Wang, C., & Li, D. (2018) · Frontiers in Pharmacology · doi:10.3389/fphar.2018.00202 · Cited by 155 · see citing works
Modulating the Tumor Microenvironment to Enhance Tumor Nanomedicine Delivery
Zhang, B., Hu, Y., & Pang, Z. (2017) · Frontiers in Pharmacology · doi:10.3389/fphar.2017.00952 · Cited by 152 · see citing works
Near infrared fluorescent peptide nanoparticles for enhancing esophageal cancer therapeutic efficacy
Fan, Z., Chang, Y., Cui, C., Sun, L., Wang, D. H., Pan, Z., & Zhang, M. (2018) · Nature Communications · doi:10.1038/s41467-018-04763-y · Cited by 151 · see citing works
Distribution kinetics of a micelle-forming block copolymer Pluronic P85
Batrakova, E. V., Li, S., Li, Y., Alakhov, V. Y., Elmquist, W. F., & Kabanov, A. V. (2004) · Journal of Controlled Release · doi:10.1016/j.jconrel.2004.09.002 · Cited by 121 · see citing works
Magnetoliposomes for controlled drug release in the presence of low-frequency magnetic field
Nappini, S., Bombelli, F. B., Bonini, M., Nordèn, B., & Baglioni, P. (2010) · Soft Matter · doi:10.1039/b915651h · Cited by 113 · see citing works
Advancing pharmaceutical research: A comprehensive review of cutting-edge tools and technologies
Chen, J., Lin, A., & Luo, P. (2024) · Current Pharmaceutical Analysis · doi:10.1016/j.cpan.2024.11.001 · Cited by 112 · see citing works
The Therapeutic Potential and Clinical Significance of Exosomes as Carriers of Drug Delivery System
Li, T., Li, X., Han, G., Liang, M., Yang, Z., Zhang, C., Huang, S., Tai, S., & Yu, S. (2022) · Pharmaceutics · doi:10.3390/pharmaceutics15010021 · Cited by 110 · see citing works
Electrospun composite nanofiber-based transmucosal patch for anti-diabetic drug delivery
Sharma, A., Gupta, A., Rath, G., Goyal, A., Mathur, R. B., & Dhakate, S. R. (2013) · Journal of Materials Chemistry B · doi:10.1039/c3tb20487a · Cited by 108 · see citing works
Chen, H., Gao, J., Lu, Y., Kou, G., Zhang, H., Fan, L., Sun, Z., Guo, Y., & Zhong, Y. (2008) · Journal of Controlled Release · doi:10.1016/j.jconrel.2008.03.010 · Cited by 97 · see citing works
Thambi, T., Son, S., Lee, D. S., & Park, J. H. (2016) · Acta Biomaterialia · doi:10.1016/j.actbio.2015.10.011 · Cited by 95 · see citing works
Targeted binding of PLA microparticles with lipid-PEG-tethered ligands
Duncanson, W. J., Figa, M. A., Hallock, K., Zalipsky, S., Hamilton, J. A., & Wong, J. Y. (2007) · Biomaterials · doi:10.1016/j.biomaterials.2007.05.044 · Cited by 75 · see citing works
Tang, Z., Zhang, L., Wang, Y., Li, D., Zhong, Z., & Zhou, S. (2016) · Acta Biomaterialia · doi:10.1016/j.actbio.2016.06.038 · Cited by 73 · see citing works
Jin, Y., Liang, X., An, Y., & Dai, Z. (2016) · Bioconjugate Chemistry · doi:10.1021/acs.bioconjchem.6b00603 · Cited by 72 · see citing works
Li, L., Wang, J., Kong, H., Zeng, Y., & Liu, G. (2018) · Science and Technology of Advanced Materials · doi:10.1080/14686996.2018.1528850 · Cited by 71 · see citing works
de Maar, J. S., Sofias, A. M., Porta Siegel, T., Vreeken, R. J., Moonen, C., Bos, C., & Deckers, R. (2020) · Theranostics · doi:10.7150/thno.38625 · Cited by 71 · see citing works
Callari, M., De Souza, P. L., Rawal, A., & Stenzel, M. H. (2017) · Angewandte Chemie International Edition · doi:10.1002/anie.201701471 · Cited by 68 · see citing works
Nanodelivery Systems for Nucleic Acid Therapeutics in Drug Resistant Tumors
Iyer, A. K., Duan, Z., & Amiji, M. M. (2014) · Molecular Pharmaceutics · doi:10.1021/mp500024p · Cited by 55 · see citing works
Zhang, B., Jin, K., Jiang, T., Wang, L., Shen, S., Luo, Z., Tuo, Y., Liu, X., Hu, Y., & Pang, Z. (2017) · Scientific Reports · doi:10.1038/s41598-017-09520-7 · Cited by 49 · see citing works
Zhang, B., Jiang, T., Tuo, Y., Jin, K., Luo, Z., Shi, W., Mei, H., Hu, Y., Pang, Z., & Jiang, X. (2017) · Cancer Letters · doi:10.1016/j.canlet.2017.09.007 · Cited by 41 · see citing works
Zhang, B., Shi, W., Jiang, T., Wang, L., Mei, H., Lu, H., Hu, Y., & Pang, Z. (2016) · Oncotarget · doi:10.18632/oncotarget.11546 · Cited by 41 · see citing works
Short Peptide-Mediated Brain-Targeted Drug Delivery with Enhanced Immunocompatibility
Guan, J., Jiang, Z., Wang, M., Liu, Y., Liu, J., Yang, Y., Ding, T., Lu, W., Gao, C., Qian, J., et al. (2019) · Molecular Pharmaceutics · doi:10.1021/acs.molpharmaceut.8b01216 · Cited by 34 · see citing works
Microfluidic co-culture devices to assess penetration of nanoparticles into cancer cell mass
Jarvis, M., Arnold, M., Ott, J., Pant, K., Prabhakarpandian, B., & Mitragotri, S. (2017) · Bioengineering & Translational Medicine · doi:10.1002/btm2.10079 · Cited by 32 · see citing works
Chernenko, T., Buyukozturk, F., Miljkovic, M., Carrier, R., Diem, M., & Amiji, M. (2013) · Drug Delivery and Translational Research · doi:10.1007/s13346-013-0178-3 · Cited by 24 · see citing works
CPX-351 in acute myeloid leukemia: can a new formulation maximize the efficacy of old compounds?
Brunetti, C., Anelli, L., Zagaria, A., Specchia, G., & Albano, F. (2017) · Expert Review of Hematology · doi:10.1080/17474086.2017.1369400 · Cited by 23 · see citing works
Proteomic studies of micronutrient deficiency and toxicity
Ali, A., Bhat, B. A., Rather, G. A., Malla, B. A., & Ganie, S. A. (2020) · Plant Micronutrients · doi:10.1007/978-3-030-49856-6_11 · Cited by 15 · see citing works
Izraylit, V., Gould, O. E. C., Kratz, K., & Lendlein, A. (2020) · MRS Advances · doi:10.1557/adv.2019.465 · Cited by 4 · see citing works
- Authors
- Allen, T. M., & Cullis, P. R.
- Affiliations
- University of British Columbia (CA)
- Corresponding author
- Allen, Theresa M.
- ORCID
- Cullis, Pieter R.
- Venue
- Science
- Published
- 2004-03-19
- Volume
- 303
- Issue
- 5665
- Pages
- 1818-1822
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2013470095
- Cited by
- 4,552
- References
- 51
- Citations by year
- 2026: 82 · 2025: 146 · 2024: 177 · 2023: 167 · 2022: 205 · 2021: 223 · 2020: 225 · 2019: 273 · 2018: 279 · 2017: 278 · 2016: 292 · 2015: 272 · 2014: 309 · 2013: 269 · 2012: 254
- FWCI
- 62.23
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Science (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Advanced Drug Delivery Systems
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA Interference and Gene Delivery
- Keywords
- drug delivery systems, nanoparticles, lipid nanoparticles, polymeric nanoparticles, parenteral drug administration, anticancer agents, antifungal agents, targeted drug delivery
- MeSH terms
- Biological Availability, Drug Carriers, Drug Stability, Pharmaceutical Preparations, Liposomes, Pharmacokinetics, Tissue Distribution, Drug Delivery Systems, Drug Costs, Nanotechnology
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