Adhesive nanoparticles with inflammation regulation for promoting skin flap regeneration
Abstract
Local drug delivery systems have become an important field of research as locally administration of medications may overcome most of the drawbacks associated with systemic drugs. Still, to assure continuous drug release and therapeutic drug levels, keeping the delivered drug in target area remains a physiological challenge. The aim of this study was to develop novel multipotent flap-protective adhesive mangiferin (MF)-loaded liposomes (A-MF-Lip), bioinspired in mussel architecture, for the promotion of random skin flap regeneration. The long chain 1,2-distearoyl-sn-glycero-3-phosphoethanolamine-poly(ethyleneglycol)-dopamine (DSPE-PEG-DOPA) was successful combined in liposomes, being dopamine (DOPA) with terminated catechol attached at the end of chain to explore the potential ability in adherence. A-MF-Lip presented a mean particle size of 162 nm, and MF cumulative release reaching 82% up to 72 h. A-MF-Lip adhesive ability was significantly higher compared to non-adhesive mangiferin-loaded liposome (MF-Lip). Moreover, a positive effect of A-MF-Lip on cells proliferation, angiogenesis was observed. And by regulating the PPAR-γ/NF-κB pathway, the A-MF-Lip established a protection effect on hypoxia induced cell apoptosis and inflammation. After locally injection delivery in a Sprague Dawley rat random skin flap model, A-MF-Lip significantly decreased flap necrosis rate and reduced flap inflammation. Therefore, A-MF-Lip is a promising multipotent flap-protective approach for rand…
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MGF mitigates chronic inflammation and oxidative stress in diabetes through inhibition of HIF-1α and NF-κB signaling, suppression of JNK phosphorylation, and reduction in endoplasmic reticulum stress, collectively restoring insulin signaling.
“Given that chronic inflammation and oxidative stress are central to the development of diabetes (29), MGF mitigates these processes through the inhibition of HIF-1α and NF-κB signaling, the suppression of JNK phosphorylation, and the reduction in endoplasmic reticulum stress, collectively restoring insulin signaling (30).”
From Mangiferin in human disease: Multifaceted mechanisms and applications (Review) (2026) · cites this paper as [29]
In rat models of skin injury, MGF-loaded hydrogels or liposomes (10, 20, and 40 μM) accelerate flap regeneration.
“In wound healing, MGF-loaded hydrogels or liposomes (10, 20 and 40 μM) have been reported to accelerate flap regeneration in rat models of skin injury.”
From Mangiferin in human disease: Multifaceted mechanisms and applications (Review) (2026) · cites this paper as [29]
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The management of diabetes mellitus by mangiferin: advances and prospects
Wang, M., Liang, Y., Chen, K., Wang, M., Long, X., Liu, H., Sun, Y., & He, B. (2022) · Nanoscale · doi:10.1039/d1nr06690k · Cited by 56 · see citing works
Mangiferin in human disease: Multifaceted mechanisms and applications (Review)
Dai, Y., Huang, Q., Tan, M., Wang, Z., Jiang, C., Liu, Z., Zhang, S., & Song, S. (2026) · International Journal of Molecular Medicine · doi:10.3892/ijmm.2026.5736 · Cited by 3 · see citing works
“Given that chronic inflammation and oxidative stress are central to the development of diabetes (29), MGF mitigates these processes through the inhibition of HIF‑1 α and NF‑ κ B signaling, the suppression of JNK phosphorylation, and the reduction in endoplasmic reticulum stress, collectively…”
Influential
- Authors
- Mao, X., Liu, L., Cheng, L., Cheng, R., Zhang, L., Deng, L., Sun, X., Zhang, Y., Sarmento, B., & Cui, W.
- Affiliations
- Shanghai Jiao Tong University (CN)
- Universidade do Porto (PT)
- Corresponding author
- Sun, Xiaoming
- Zhang, Yuguang
- Sarmento, Bruno
- Cui, Wenguo
- ORCID
- Venue
- Journal of Controlled Release
- Publisher
- Elsevier BV
- Published
- 2019-03
- Volume
- 297
- Pages
- 91-101
- ISSN
- 0168-3659 (ISSN-L)
- OpenAlex
- W2912125471
- Cited by
- 45
- References
- 2
- Citations by year
- 2026: 3 · 2025: 1 · 2024: 6 · 2023: 8 · 2022: 5 · 2021: 7 · 2020: 10 · 2019: 5
- FWCI
- 1.91
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Controlled Release (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Natural Science Foundation of China (81772099, 81701907, 81772087, 51873107)
- Shanghai Sailing Program (18YF1412400)
- Shanghai Municipal Education Commission—Gaofeng Clinical Medicine Grant Support (20171906)
- Shanghai Talent Development Fund
- Science and Technology Commission of Shanghai Municipality (18ZR1434200)
- Shanghai Jiao Tong University (2018099, ZH2018ZDA04)
- Norte Portugal Regional Operational Programme (NORTE 2020)
- European Regional Development Fund
- Topics
- Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
- Health Sciences › Medicine › Rehabilitation › Wound Healing and Treatments
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Advancements in Transdermal Drug Delivery
- Keywords
- mangiferin, liposomes, flap necrosis, mussel-inspired adhesives, hypoxia-induced apoptosis, angiogenesis, local drug delivery
- MeSH terms
- Adhesives, Animals, Anti-Inflammatory Agents, Dopamine, Humans, Inflammation, Liposomes, Male, Phosphatidylethanolamines, Polyethylene Glycols, Regeneration, Skin, Signal Transduction, NF-kappa B, Rats, Sprague-Dawley, Xanthones, PPAR gamma, Cell Proliferation, Rats, Nanocapsules, Human Umbilical Vein Endothelial Cells, Drug Liberation
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