Cited by 300Nanoparticle-Based Drug DeliveryCharacterization and Applications of Magnetic NanoparticlesMicro and Nano Robotics

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A review of magnet systems for targeted drug delivery

Liu, Ya-Li, Chen, Da, Shang, Peng, Yin, Da-Chuan·2019·Journal of Controlled Release

DOI 10.1016/j.jconrel.2019.03.031

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Abstract

Magnetic drug targeting is a method by which magnetic drug carriers in the body are manipulated by external magnetic fields to reach the target area. This method is potentially promising in applications for treatment of diseases like cancers, nervous system diseases, sudden sensorineural hearing loss, and so on, due to the advantages in that it can improve efficacy, reduce drug dosage and side effects. Therefore, it has received extensive attention in recent years. Successful magnetic drug targeting requires a good magnet system to guide the drug carriers to the target site. Up to date there have been many efforts to design the magnet systems for targeted drug delivery. However, there are few comprehensive reviews on these systems. Here we review the progresses made in this field. We summarized the systems already developed or proposed, and categorized them into two groups: static field magnet systems and varying field magnet systems. Based on the requirements for more powerful targeting performance, the prospects and the future research directions in this field are anticipated.

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Authors: Liu, Y.-L., Chen, D., Shang, P., & Yin, D.-C.
Affiliations: Northwestern Polytechnical University (CN)
Corresponding author: Yin, Da-Chuan
ORCID: Chen, Da
Shang, Peng
Yin, Da-Chuan
Venue: Journal of Controlled Release
Publisher: Elsevier BV
Published: 2019-05
Volume: 302
Pages: 90-104
ISSN: 0168-3659 (ISSN-L)
DOI: 10.1016/j.jconrel.2019.03.031
OpenAlex: W2926277738
Cited by: 298
References: 193
Citations by year: 2026: 17 · 2025: 49 · 2024: 42 · 2023: 49 · 2022: 46 · 2021: 51 · 2020: 36 · 2019: 8
FWCI: 2.24
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
Locations: Journal of Controlled Release (publishedVersion)
PubMed (publishedVersion)
Funders: National Natural Science Foundation of China (U1632126)
921 project of China (17430206)
Topics: Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
Physical Sciences › Engineering › Biomedical Engineering › Characterization and Applications of Magnetic Nanoparticles
Physical Sciences › Physics and Astronomy › Condensed Matter Physics › Micro and Nano Robotics
Keywords: magnetic drug delivery, targeted drug delivery, magnet system, magnetic drug carriers, external magnetic field, cancer therapy, neurological disorders, sudden sensorineural hearing loss
MeSH terms: Superconductivity, Animals, Delayed-Action Preparations, Drug Carriers, Humans, Neoplasms, Nervous System Diseases, Hearing Loss, Nanoparticles, Magnets, Magnetic Fields, Drug Liberation

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