Interaction of ultraviolet light with the cornea: clinical implications for corneal crosslinking
Abstract
Unlabelled Understanding ultraviolet (UV) interaction with the human corneal tissue is of interest among corneal specialists given the widespread application of corneal crosslinking. This article reviews the current knowledge of light interaction with the cornea in the UV wavelength range. It also uses a novel experimental study to illustrate the role of 2 important corneal properties that have not yet been clarified: the epithelial contribution to overall UVA corneal absorbance and the regional anisotropy of UVA light transmittance. Finally, it presents the most recent insights into how different methods of UVA light irradiation and corneal soaking with riboflavin influence the outcome of corneal crosslinking. Financial disclosure No author has a financial or proprietary interest in any material or method mentioned.
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UVA transmission decreases almost linearly from the centre to the periphery in all meridians.
“The authors found that UVA transmission decreases almost linearly from the centre to the periphery in all meridians”
From Corneal structure and transparency (2015) · cites this paper as Lombardo et al., 2015
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Corneal structure and transparency
Meek, K. M., & Knupp, C. (2015) · Progress in Retinal and Eye Research · doi:10.1016/j.preteyeres.2015.07.001 · Cited by 853 · see citing works
- Authors
- Lombardo, M., Pucci, G., Barberi, R., & Lombardo, G.
- Affiliations
- Vision Engineering (Italy) (IT)
- University of Miami (US)
- Corresponding author
- Lombardo, Marco
- Venue
- Journal of Cataract and Refractive Surgery
- Published
- 2015-02
- Volume
- 41
- Issue
- 2
- Pages
- 446-459
- ISSN
- 0146-2776 (ISSN-L)
- 0886-3350
- OpenAlex
- W2099340856
- Cited by
- 62
- References
- 0
- Citations by year
- 2026: 4 · 2025: 1 · 2024: 5 · 2023: 4 · 2022: 8 · 2021: 4 · 2020: 4 · 2019: 4 · 2018: 9 · 2017: 8 · 2016: 6 · 2015: 5
- FWCI
- 0.98
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Cataract & Refractive Surgery (publishedVersion)
- PubMed (publishedVersion)
- HAL (submittedVersion)
- Archive of Doctoral Theses and Digital Collections (University of Calabria) (submittedVersion)
- Topics
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Corneal surgery and disorders
- Health Sciences › Medicine › Ophthalmology › Ocular and Laser Science Research
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Ocular Surface and Contact Lens
- Keywords
- ultraviolet radiation, cornea, corneal cross-linking, UVA, corneal epithelium
- MeSH terms
- Collagen, Cornea, Cross-Linking Reagents, Humans, Riboflavin, Ultraviolet Rays, Anisotropy, Photosensitizing Agents, Epithelium, Corneal
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