Prediction of unfavorable outcomes in West Nile virus neuroinvasive infection – Result of a multinational ID-IRI study
Abstract
Background WNV causes 1.4% of all central nervous system infections and is the most common cause of epidemic neuro-invasive disease in humans. Objectives Our main objective was to investigate retrospectively West Nile virus neuroinvasive disease (WNND) cases hospitalized during 2010-2017 and identified factors that can influence prognosis. Study design We documented the demographic, epidemiologic, clinical and laboratory data of WNND and identified factors that can influence prognosis. The data were recruited through Infectious Diseases International Research Initiative (ID-IRI), which serves as a network for clinical researches. Results We investigated 165 patients with WNND in 10 countries from three continents. 27 patients died and the mortality rate was 16.4%. In an univariate analysis age, congestive heart failure, neoplasm and ischemic heart disease (p Conclusions WNND remain an important factor for morbidity and mortality worldwide, evolution to death or survival with sequelae are not rare. Our study creates an equation that may be used in the future to establish the prognosis of WNND patients.
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Movement disorders persist for months to years in WNE patients.
“Movement disorders persist for months to years [83, 87–91].”
From Cognitive decline following acute viral infections: literature review and projections for post-COVID-19 (2022) · cites this paper as [90]
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Practice Guidelines for the Management of Bacterial Meningitis
Tunkel, A. R., Hartman, B. J., Kaplan, S. L., Kaufman, B. A., Roos, K. L., Scheld, W. M., & Whitley, R. J. (2004) · Clinical Infectious Diseases · doi:10.1086/425368 · Cited by 2,308 · see citing works
Murray, K. O., Nolan, M. S., Ronca, S. E., Datta, S., Govindarajan, K., Narayana, P. A., Salazar, L., Woods, S. P., & Hasbun, R. (2018) · Frontiers in Neurology · doi:10.3389/fneur.2018.00111 · Cited by 43 · see citing works
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Damiano, R. F., Guedes, B. F., de Rocca, C. C., de Pádua Serafim, A., Castro, L. H. M., Munhoz, C. D., Nitrini, R., Filho, G. B., Miguel, E. C., Lucchetti, G., et al. (2022) · European Archives of Psychiatry and Clinical Neuroscience · doi:10.1007/s00406-021-01286-4 · Cited by 98 · see citing works
- Authors
- Popescu, C. P., Florescu, S. A., Hasbun, R., Harxhi, A., Evendar, R., Kahraman, H., Neuberger, A., Codreanu, D., Zaharia, M. F., Tosun, S., Ceausu, E., Ruta, S. M., Dragovac, G., Pshenichnaya, N., Gopatsa, G., Shmaylenko, O., Nagy, É., Malbasa, J. D., Strbac, M., Pandak, N., Pullukcu, H., Lakatos, B., Cag, Y., Cascio, A., Coledan, I., Oncu, S., & Erdem, H.
- Affiliations
- Carol Davila University of Medicine and Pharmacy (RO)
- The University of Texas Health Science Center at Houston (US)
- Technion – Israel Institute of Technology (IL)
- Ege University (TR)
- Izmir Bozyaka Eğitim ve Araştırma Hastanesi (TR)
- University of Novi Sad (RS)
- Rostov State Medical University (RU)
- City Hospital № 1 named after. ON. Semashko (RU)
- University of Split (HR)
- Unified Szent István and Szent László Hospital (HU)
- University of Palermo (IT)
- University of Verona (IT)
- European Society of Clinical Microbiology and Infectious Diseases (CH)
- Corresponding author
- Popescu, Corneliu Petru
- ORCID
- Venue
- Journal of Clinical Virology
- Publisher
- Elsevier BV
- Published
- 2020-01
- Volume
- 122
- Pages
- 104213
- ISSN
- 1386-6532 (ISSN-L)
- OpenAlex
- W2987545826
- Cited by
- 28
- References
- 2
- Citations by year
- 2026: 3 · 2025: 3 · 2024: 6 · 2023: 6 · 2022: 2 · 2021: 6 · 2020: 2
- FWCI
- 2.31
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Clinical Virology (publishedVersion)
- PubMed (publishedVersion)
- Nova Science Publishers (Nova Science Publishers, Inc.) (submittedVersion)
- Funders
- CCCDI-UEFISCDI
- Topics
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Mosquito-borne diseases and control
- Health Sciences › Medicine › Infectious Diseases › Infectious Encephalopathies and Encephalitis
- Health Sciences › Medicine › Infectious Diseases › Viral Infections and Vectors
- Keywords
- West Nile virus, neuroinvasive disease, prognosis, mortality risk factors, coma, age, comorbidities, Glasgow coma score, prognostic equations, central nervous system infection
- MeSH terms
- Adult, Aged, Aged, 80 and over, Central Nervous System Diseases, Female, Hospitalization, Humans, Male, Middle Aged, Mortality, Population Surveillance, Predictive Value of Tests, Retrospective Studies, Tomography, X-Ray Computed, West Nile Fever, West Nile virus, Glasgow Coma Scale, Internationality
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