Predictors of manufacturing (MFG) success for chimeric antigen receptor (CAR) T cells in non-Hodgkin lymphoma (NHL)
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The presence of MDSCs and monocytes can hamper the ex vivo activation and expansion of T cells, and other contaminants such as granulocytes and red blood cells suppress T cell proliferation.
“The presence of MDSCs and monocytes can hamper the ex vivo activation and expansion of T cells (40,42-44). Other cellular contaminants such as granulocytes and red blood cells suppress T cell proliferation (45,46).”
From Scalable Manufacturing of CAR T Cells for Cancer Immunotherapy (2021) · cites this paper as [40]
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Scalable Manufacturing of CAR T Cells for Cancer Immunotherapy
Abou-el-Enein, M., Elsallab, M., Feldman, S. A., Fesnak, A. D., Heslop, H. E., Marks, P., Till, B. G., Bauer, G., & Savoldo, B. (2021) · Blood Cancer Discovery · doi:10.1158/2643-3230.bcd-21-0084 · Cited by 321 · see citing works
Self-citationThe challenge of variability in chimeric antigen receptor T cell manufacturing
Fesnak, A. D. (2020) · Regenerative Engineering and Translational Medicine · doi:10.1007/s40883-019-00124-3 · Cited by 45 · see citing works
Self-citationAbabneh, H., Abramson, J. S., Johnson, P. C., & Patel, C. G. (2022) · Radiotherapy and Oncology · doi:10.1016/j.radonc.2022.08.007 · Cited by 33 · see citing works
CAR-T manufactured from frozen PBMC yield efficient function with prolonged in vitro production
Abraham-Miranda, J., Menges, M. A., Atkins, R. M., Mattie, M., Kanska, J. E., Turner, J. G., Hidalgo-Vargas, M. J., & Locke, F. L. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.1007042 · Cited by 17 · see citing works
Current State of the Art of Allogeneic CAR Approaches – Pile ‘Em High and Sell ’Em Cheap
Theoharis, S. (2021) · Journal of Pharmaceutical Sciences · doi:10.1016/j.xphs.2021.02.006 · Cited by 12 · see citing works
Saifi, O., Kharfan‐Dabaja, M. A., Zeidan, Y. H., Peterson, J., Rule, W. G., Lester, S. C., & Hoppe, B. S. (2020) · International Journal of Particle Therapy · doi:10.14338/ijpt-20-00004.1 · Cited by 7 · see citing works
Elsemary, M. T., Maritz, M. F., Smith, L. E., Warkiani, M. E., & Thierry, B. (2024) · Cytotherapy · doi:10.1016/j.jcyt.2024.05.005 · Cited by 6 · see citing works
Don't Get Stuck on the Shoulder: Radiation Oncologists Should Get Into the CAR With T-Cell Therapies
Plastaras, J. P., Chong, E. A., & Schuster, S. J. (2019) · International Journal of Radiation Oncology*Biology*Physics · doi:10.1016/j.ijrobp.2019.09.005 · Cited by 6 · see citing works
Self-citationYu, L., Zou, R., He, J., & Qu, C. (2024) · Critical Reviews in Oncology/Hematology · doi:10.1016/j.critrevonc.2024.104390 · Cited by 3 · see citing works
Data from Scalable Manufacturing of CAR T Cells for Cancer Immunotherapy
Abou‐El‐Enein, M., Elsallab, M., Feldman, S. A., Fesnak, A. D., Heslop, H. E., Marks, P. W., Till, B. G., Bauer, G., & Savoldo, B. (2023) · doi:10.1158/2643-3230.c.6550449
Self-citationAdeniran, A., Handy, S., & Baki, A. (2024) · Springer eBooks · doi:10.1007/978-3-031-62007-2_9
- Authors
- Davis, M. M., Fesnak, A., Leskowitz, R. M., McKee, J. S., Ohayon, Y., Corl, C. M., Malykhin, A., Fraietta, J. A., Joseph Melenhorst, J., June, C., Schuster, S., & Levine, B. L.
- Affiliations
- University of Pennsylvania (US)
- Venue
- Cytotherapy
- Publisher
- Elsevier BV
- Published
- 2017-05
- Volume
- 19
- Issue
- 5
- Pages
- S118-S119
- ISSN
- 1465-3249 (ISSN-L)
- OpenAlex
- W2611735567
- Cited by
- 11
- References
- 0
- Citations by year
- 2024: 3 · 2023: 1 · 2022: 2 · 2021: 2 · 2020: 1 · 2019: 2
- FWCI
- 0.36
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Cytotherapy (publishedVersion)
- Topics
- Health Sciences › Medicine › Oncology › CAR-T cell therapy research
- Life Sciences › Immunology and Microbiology › Immunology › Immunotherapy and Immune Responses
- Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
- Keywords
- chimeric antigen receptor T cells, CAR T cell manufacturing, non-Hodgkin lymphoma, apheresis products, CD19, relapsed/refractory lymphoma
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