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Cited by 30Hydrogels: synthesis, properties, applicationsAdvanced Drug Delivery SystemsPolymer Surface Interaction Studies

Layer-by-layer polyelectrolyte coating of alginate microgels for sustained release of sodium benzoate and zosteric acid

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Wang, Qing, Zhang Newby, Bi-min·2018·Journal of Drug Delivery Science and Technology
DOI 10.1016/j.jddst.2018.04.019PMC PMC6289541
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Abstract

The potential of sustaining release of very small (Mw < 250 g/mol) hydrophilic drugs up to several days from layer-by-layer (LbL) polyelectrolyte coated alginate microgels (Alg-Ms) was investigated. One purpose is to minimize post-surgical adhesions, which develop in 12 h to 3 days after surgery. The LbL polyelectrolyte layer would serve as a diffusion barrier for their release. The LbL polyelectrolyte bilayers were prepared using poly(allylamine) (PAH) and poly(styrene sulfonate) (PSS). Sodium benzoate (NaB, Mw = 144 g/mol) and zosteric acid (ZA, Mw = 244 g/mol), two anti-inflammatory and anti-microbial compounds, were used as model drugs. A higher number of PAH/PSS bilayer lead to a greater sustained release of both drugs, and with 4 bilayers, the release of NaB and ZA was prolonged from 24 h to 72 h and 120 h, respectively. Fitting the data to the Ritger-Peppas' equation showed that as the bilayer number increased, the release constant and/or exponent decreased, indicating the LbL PAH/PSS bilayer effectively reduced the permeability of these two very small hydrophilic drugs. The ability to prolong the release of such small hydrophilic molecules, which has rarely been investigated previously, would find broad applications in fields such as anti-adhesion treatment and antifouling coatings.

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  • A dual-surface membrane made by merging a CMC hydrogel layer with a collagen hydrogel layer through vitrification has a collagen-rich side that is slightly sticky and adheres to wet tissue, while the CMC side provides strong anti-adhesive properties, ensuring the barrier stays in place on the target organ while preventing adhesions on its outward-facing surface.

    “For example, a recent “dual-surface” membrane was made by merging a carboxymethyl cellulose (CMC) hydrogel layer with a collagen hydrogel layer through a vitrification process [276]. The resulting dry film (termed Bi-C-CVM) has a collagen-rich side that is slightly sticky, adhering to wet tissue, while the CMC side provides strong anti-adhesive properties.”

    From Biomaterials in Postoperative Adhesion Barriers and Uterine Tissue Engineering (2025) · cites this paper as [276]

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  • Coating alginate microgel cores with multiple LbL layers of polycations and polyanions can greatly prolong the release of small anti-inflammatory drugs, aiming to cover the critical 3-5 day period of post-surgery adhesion formation.

    “One approach is polyelectrolyte multilayers; researchers demonstrated that coating alginate microgel cores with multiple LbL layers of polycations and polyanions can greatly prolong the release of small anti-inflammatory drugs, aiming to cover the critical 3–5 day period of post-surgery adhesion formation [276].”

    From Biomaterials in Postoperative Adhesion Barriers and Uterine Tissue Engineering (2025) · cites this paper as [276]

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Cited by

Sorted by citations

Authors
Wang, Q., & Zhang Newby, B.-M.
Affiliations
University of Akron (US)
ORCID
Wang, Qing
Venue
Journal of Drug Delivery Science and Technology
Publisher
Elsevier BV
Published
2018-08
Volume
46
Pages
46-54
ISSN
1773-2247 (ISSN-L)
DOI
10.1016/j.jddst.2018.04.019
PMC
PMC6289541
OpenAlex
W2799307540
Cited by
30
References
1
Citations by year
2026: 5 · 2025: 2 · 2024: 3 · 2023: 5 · 2022: 1 · 2021: 7 · 2020: 5 · 2019: 1 · 2018: 1
FWCI
1.28
Type
journal article
Language
en
Open access
Licence
Locations
  • Journal of Drug Delivery Science and Technology (acceptedVersion)
  • PubMed (publishedVersion)
  • Europe PMC (PubMed Central) (acceptedVersion)
  • PubMed Central (acceptedVersion)
Funders
National Institute of General Medical Sciences of the National Institutes of Health (1R15GM097626-01A1)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Medicine › Hydrogels: synthesis, properties, applications
  • Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Advanced Drug Delivery Systems
  • Physical Sciences › Materials Science › Surfaces, Coatings and Films › Polymer Surface Interaction Studies
Keywords
alginate microgels, sustained drug release, sodium benzoate, polyallylamine, polystyrene sulfonate, postoperative adhesions, diffusion barrier, antifouling coatings

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