Abdominal adhesions: Current and novel therapies
Abstract
An adhesion occurs when two tissues that normally freely move past each other attach via a fibrous bridge. Abdominal adhesions place a tremendous clinical and financial burden on public health. Adhesions develop after nearly every abdominal surgery, commonly causing female infertility, chronic pelvic pain, and, most frequently, small bowel obstruction. A National Hospital Discharge Survey of hospitalizations between 1998 and 2002 reported that 18.1% of hospitalizations were related to abdominal adhesions annually accounting for 948,000 days of inpatient care at an estimated cost of $1.18 billion. This review discusses the current or proposed therapies for abdominal adhesions. While many therapies for abdominal adhesions have been attempted, the need for a definitive therapy to prevent or even reduce abdominal adhesions still exists.
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Biological coatings can reduce adhesion between biological tissues.
“Biological coatings can be used to reduce the adhesion between biological tissues [154].”
From Mussel-Inspired Injectable Adhesive Hydrogels for Biomedical Applications (2024) · cites this paper as [154]
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“[5] Ward BC, Panitch A.”
Raffea, N. M., & Allawi, A. H. (2022) · Iraqi Journal of Veterinary Sciences · doi:10.33899/ijvs.2021.130529.1840 · Cited by 18
“In fact, in the review of literatures, the use a combination of multiple agents was suggested to be have a synergetic effect and sufficient for adhesion formation prevention than either component alone (37).”
BackgroundTrametinib prevents mesothelial-mesenchymal transition and ameliorates abdominal adhesion formation.
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“496 Journal of Bioactive and Compatible Polymers 32(5)”
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“In contrast with the HA-CMC film, PTMC is highly flexible with sufficient tensile strength, allowing for easy positioning and repositioning within the first few minutes after implantation,(18,34) whereas the HA-CMC film is reported to be brittle, sticky, and difficult to apply, limiting its use in surgical practice.(1…”
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Intraperitoneal Administration of Telmisartan Prevents Postsurgical Adhesion Band Formation.
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Rosmarinic acid prevents post-operative abdominal adhesions in a rat model
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The Prevention of Hepatectomy-Induced Adhesions by Bilayer Sponge Composed of Ultrapure Alginate.
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Fucoidans inhibit the formation of post-operative abdominal adhesions in a rat model
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- Authors
- Ward, B. C., & Panitch, A.
- Affiliations
- Purdue University West Lafayette (US)
- Corresponding author
- Panitch, Alyssa
- Venue
- Journal of Surgical Research
- Publisher
- Elsevier BV
- Published
- 2011-01
- Volume
- 165
- Issue
- 1
- Pages
- 91-111
- ISSN
- 0022-4804 (ISSN-L)
- OpenAlex
- W2122017924
- Cited by
- 249
- References
- 315
- Citations by year
- 2026: 11 · 2025: 17 · 2024: 13 · 2023: 18 · 2022: 17 · 2021: 14 · 2020: 18 · 2019: 19 · 2018: 21 · 2017: 18 · 2016: 15 · 2015: 16 · 2014: 21 · 2013: 12 · 2012: 10
- FWCI
- 1.01
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Surgical Research (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Heart, Lung, and Blood Institute (K25HL074968)
- National Institute of General Medical Sciences (GM 077229, T32GM077229)
- Topics
- Health Sciences › Medicine › Surgery › Intestinal and Peritoneal Adhesions
- Health Sciences › Medicine › Surgery › Hernia repair and management
- Health Sciences › Medicine › Surgery › Surgical Sutures and Adhesives
- Keywords
- peritoneal adhesions, postoperative adhesions, adhesion prevention, small bowel obstruction, female infertility, chronic pelvic pain, abdominal surgery complications
- MeSH terms
- Abdomen, Tissue Adhesions, Animals, Cellulose, Oxidized, Humans, Hyaluronic Acid
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