Comparative studies on level of androgens in hair and plasma with premature male-pattern baldness
Abstract
Background It is well known that male-pattern baldness (MPB) is not started from occipital, but frontal or scalp of head. We can assume that distribution of androgenic steroids is different for each region of the head.Objective We hypothesize that the levels of androgenic steroids are different not only between vertex hair with MPB and controls but also between occipital hair with MPB and controls. Moreover, we want to search for the biochemical indicator in plasma and hair sample (baldness: 22, non-baldness: 13) obtained from dermatology of medical center. After then, we desire to present fundamental data regarding diagnosis, medical cure, and prevention for premature MPB.Methods After hair and plasma were hydrolyzed, and then extracted with organic solvent. To assess androgenic steroids levels, we used gas chromatography-mass spectrometry (GC-MS) system in selected ion monitoring mode.Results The level of dihydrotestosterone (DHT) and the ratio of testosterone to epitestosterone (T/E ratio) in vertex hair from premature baldness subjects were higher than in the sample of non-baldness subjects (P<0.001, 0.001), whereas the levels of androgens in occipital hair from the same baldness group were not different. In addition, we discovered the levels of DHT, testosterone, and DHT/T ratio in plasma from premature MPB were higher than in those of control subjects (P<0.001, 0.001, 0.005).Conclusion We verified that the distribution of androgenic steroids is unlike in various regions of individual subjects. Moreover, the increased DHT/T ratio in balding plasma indirectly confirms the high activity of 5alpha-reductase type II.
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Testosterone and dihydrotestosterone likely have differential roles and expression in various tissues, including prostate, skin, penis, and testicles.
“T and DHT also likely have differential roles and expression in various tissues, including in the prostate, skin, penis, and testicles, among others.”
From Challenges in Testosterone Measurement, Data Interpretation, and Methodological Appraisal of Interventional Trials (2016) · cites this paper as [25]
Cites
Sawaya, M. E., & Price, V. H. (1997) · Journal of Investigative Dermatology · doi:10.1111/1523-1747.ep12335779 · Cited by 501 · see citing works
Molecular mechanisms of androgenetic alopecia
Trüeb, R. M. (2002) · Experimental Gerontology · doi:10.1016/s0531-5565(02)00093-1 · Cited by 368 · see citing works
ANDROGEN METABOLISM AS IT AFFECTS HAIR GROWTH IN ANDROGENETIC ALOPECIA
Kaufman, K. D. (1996) · Dermatologic Clinics · doi:10.1016/s0733-8635(05)70396-x · Cited by 185 · see citing works
Serum Androgens: Associations With Prostate Cancer Risk and Hair Patterning
Demark‐Wahnefried, W., Lesko, S. M., Conaway, M. R., Robertson, C. N., Clark, R. V., Lobaugh, B., Mathias, B. J., Strigo, T. S., & Paulson, D. F. (1997) · Journal of Andrology · doi:10.1002/j.1939-4640.1997.tb01964.x · Cited by 107 · see citing works
Androgenetic alopecia and prostate cancer: findings from an Australian case-control study.
Giles, G. G., Severi, G., Sinclair, R., et al. (2002) · PubMed · Cited by 97 · see citing works
Ebling, F. J. G. (1987) · Dermatologic Clinics · doi:10.1016/s0733-8635(18)30728-9 · Cited by 91 · see citing works
Choi, M. H., Yoo, Y. S., & Chung, B. C. (2001) · Journal of Investigative Dermatology · doi:10.1046/j.1523-1747.2001.00188.x · Cited by 49 · see citing works
Self-citationPartial characterization of epididymal 5α reductase in the rat
Monsalve, A., & Blaquier, J. A. (1977) · Steroids · doi:10.1016/0039-128x(77)90135-0 · Cited by 45 · see citing works
Steroid 5α-reductase inhibitors in androgen-dependent disorders
Harris, G. S., & Kozarich, J. W. (1997) · Current Opinion in Chemical Biology · doi:10.1016/s1367-5931(97)80017-8 · Cited by 44 · see citing works
Epitestosterone: A Potential New Antiandrogen
Nuck, B. A., & Lucky, A. W. (1987) · Journal of Investigative Dermatology · doi:10.1111/1523-1747.ep12470564 · Cited by 36 · see citing works
Epitestosterone—an endogenous antiandrogen?
Stárka, L., Bičı́ková, M., & Hampl, R. (1989) · Journal of Steroid Biochemistry · doi:10.1016/0022-4731(89)90255-0 · Cited by 36 · see citing works
Sex hormone-binding globulin and saliva testosterone levels in men with androgenetic alopecia
Cipriani, R., Ruzza, G., Foresta, C., et al. (1983) · British Journal of Dermatology · doi:10.1111/j.1365-2133.1983.tb03538.x · Cited by 31 · see citing works
Measurement of testosterone and pregnenolone in nails using gas chromatography–mass spectrometry
Choi, M. H., Yoo, Y. S., & Chung, B. C. (2001) · Journal of Chromatography B Biomedical Sciences and Applications · doi:10.1016/s0378-4347(01)00038-x · Cited by 31 · see citing works
Self-citationHormonal Parameters in Androgenetic Hair Loss in the Male
Schmidt, J. B., Lindmaier, A., & Spona, J. (2009) · Dermatologica · doi:10.1159/000247797 · Cited by 26 · see citing works
Choi, M. H., Chung, B. C., & Kim, J. Y. (1999) · The Analyst · doi:10.1039/a901242g · Cited by 26 · see citing works
Self-citationLerchl, A., & Nieschlag, E. (1995) · General and Comparative Endocrinology · doi:10.1006/gcen.1995.1053 · Cited by 19 · see citing works
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Trost, L. W., & Mulhall, J. P. (2016) · The Journal of Sexual Medicine · doi:10.1016/j.jsxm.2016.04.068 · Cited by 98 · see citing works
van der Merwe, J., Brooks, N. E., & Myburgh, K. H. (2009) · Clinical Journal of Sport Medicine · doi:10.1097/jsm.0b013e3181b8b52f · Cited by 29 · see citing works
- Authors
- Bang, H.-J., Yang, Y. J., Lho, D.-S., Lee, W.-Y., Sim, W. Y., & Chung, B. C.
- Affiliations
- Yonsei University (KR)
- Korea Institute of Science and Technology (KR)
- Kyung Hee University (KR)
- Corresponding author
- Chung, Bong Chul
- Venue
- Journal of Dermatological Science
- Publisher
- Elsevier BV
- Published
- 2004-02
- Volume
- 34
- Issue
- 1
- Pages
- 11-16
- ISSN
- 0923-1811 (ISSN-L)
- OpenAlex
- W1973247565
- Cited by
- 51
- References
- 16
- Citations by year
- 2026: 1 · 2025: 3 · 2024: 5 · 2023: 1 · 2022: 4 · 2021: 2 · 2020: 7 · 2019: 4 · 2018: 3 · 2017: 3 · 2016: 3 · 2015: 1 · 2014: 1 · 2013: 1 · 2012: 3
- FWCI
- 0.33
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Dermatological Science (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Urology › Hair Growth and Disorders
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hormonal and reproductive studies
- Health Sciences › Medicine › Reproductive Medicine › Sperm and Testicular Function
- Keywords
- androgenetic alopecia, androgens, dihydrotestosterone, plasma androgen levels
- MeSH terms
- Adult, Age Factors, Alopecia, Hair, Humans, Male, Dihydrotestosterone, Testosterone, Biomarkers
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